葉酸 Folate

INT-folate-001 7 個適應症被研究
S 1 A 3 B 2 C 1

適應症與證據等級

法規與權威立場 (L4)

L4a · US FDA
立場:supportive
Health claims relating folate to risk of neural tube defects may be made on the label or in labeling of foods, including dietary supplements, provided that the requirements in this section are met.
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L4b · EU EFSA
立場:supportive
L4c · UK NHS
立場:neutral
It's recommended that all women who could get pregnant should take a 400 microgram folic acid supplement daily before pregnancy and until they're 12 weeks pregnant.
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L4d · TW TFDA / 衛福部
立場:supportive
孕期缺乏葉酸,會增加胎兒腦及脊髓先天性神經管缺陷的風險。育齡婦女及準備懷孕婦女可在準備階段每日攝取400微克,懷孕期間每日攝取600微克。
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L4e · WHO
立場:neutral
Current evidence suggests that folic acid supplementation in the periconceptional period, either alone or in combination with other vitamins and minerals, can prevent neural tube defects.
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市場與行銷 (L10)

L10a · TW Market Channels
孕哺兒媽媽葉酸口嚼錠:60錠/盒,成分為葉酸400微克,每日補充1顆,價格約NT$499
L10b · TW Legal Identity (TFDA)
懷孕婦女自懷孕前1個月至整個孕期,每日應攝取600微克葉酸,且不宜超過1000微克
L10c · TW Community (PTT/Dcard/Mobile01)
孕婦在懷孕首一個月時,若每日服用少於500微克的葉酸,自閉症病發率減少六成半;當服食超過1000微克,病發率更降低約八成。完全沒進食葉酸的組別自閉症風險最高。但若葉酸攝取超過適當劑量四倍,會使新生兒罹患自閉症的風險加倍;若同時攝取過多維生素B12,風險更增為17.6倍。