尿石素A Urolithin A × 運動耐力

結論:證據分歧

證據基礎窄且呈現一致的『主要終點 NULL/次級終點正向』分裂模式:4 篇 RCT 總 n≈216,peak power(Singh 2022)、6MWD(Liu 2022)、3000 m time trial(Sports Med 2025)等預設主要終點皆未達顯著,但 muscle endurance、VO2max within-group、RPE、CK 等次級/生物標記終點呈一致正面訊號。

C 🟠 C 薄弱證據 證據分歧 🚨 high — heavy affiliate marketing in TW community
⚠️ 標記 ⚠️ 廠商資助研究

證據基礎窄且呈現一致的『主要終點 NULL/次級終點正向』分裂模式:4 篇 RCT 總 n≈216,peak power(Singh 2022)、6MWD(Liu 2022)、3000 m time trial(Sports Med 2025)等預設主要終點皆未達顯著,但 muscle endurance、VO2max within-group、RPE、CK 等次級/生物標記終點呈一致正面訊號。

L1 Examine monograph 存在但 evidence table 為空(『No Study Database』)等同無證據評級可參照;ACSM/IOC/ISSN 無立場、AIS ABCD 框架未將 UA 列入 A/B/C/D 任一類,且 2025 Sports Med 高訓練量男性距離跑者試驗(PMID 40839339)3000 m TT 未改善;4 篇中至少 3 篇為 Amazentis SA 贊助或員工撰寫,產業 COI 深重。

安全層級雖獲 FDA GRAS、EFSA 正面意見、TGA Compositional Guideline、Health Canada NPN 多重背書,但僅限食品安全,未核可任何耐力/表現宣稱。

C 級(薄弱證據/機轉合理 + 少量人體研究,主要終點未達成)為最誠實判讀。

⚖️

評分透明度

所有分數由 7 層證據引擎計算,過程公開可查
原始分數 0.50
D
C
B
A
S
← 反證據 / 無效有效 / 強證據 →
最終評級
C · 證據分歧
信心度
61%
證據方向大致一致
證據層級
E6
多篇較小型隨機對照試驗

各層「支持此療效」的程度

分數越低=該層越不支持
L1 Examine國際基準
0.50
L3 機轉生理合理性
0.50
L5 臨床機構權威立場
0.50
L11 AI 複核獨立判讀
0.50
L2 PubMed原始文獻
0.60
不支持 中性 / 混合 支持
查看完整決策路徑(audit trail)
  1. compute_raw_score — 加權公式: L2×0.30 + L3×0.25 + L5×0.25 + L11×0.10 + L1×0.10 = 0.503
  2. tier_from_score — 依分數區間映射至 tier letter
  3. apply_hec_rules — 無高階證據可裁決
  4. tier_strict_requirement_check — Tier 條件達標,未降階
  5. detect_disputes — 偵測到 1 個 hard + 1 個 soft dispute
  6. decide_status — 依 tier + dispute 結果決定 status

Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in middle-aged adults
PMID: 35584623 2022 RCT (double-blind) n = 88
結論:Primary endpoint (peak power output) NOT met; secondary endpoints showed within-group peak VO2 increase at 1000 mg (p<0.01) and hamstring strength gains at both doses (p=0.027 / p=0.029 vs placebo)
⚠️ 廠商資助
前往 PubMed
Effect of Urolithin A Supplementation on Muscle Endurance and Mitochondrial Health in Older Adults: A Randomized Clinical Trial
PMID: 35050355 2022 RCT (double-blind) n = 66
結論:Muscle endurance (FDI and tibialis anterior) significantly improved at 2 months (p<0.01); primary 6MWD (UA +60.8m vs placebo +42.5m) and ATP production NOT statistically significant
⚠️ 廠商資助
前往 PubMed
Urolithin A Supplementation on Running Performance, Recovery, and Mitochondrial Biomarkers in Highly Trained Male Distance Runners
PMID: 40839339 2025 RCT (double-blind) n = 42
結論:3000 m time trial NOT improved (p=0.116); VO2max within-group +5.4% in UA (p=0.009) vs +3.6% placebo (p=0.098); RPE lower (p=0.02); CK damage marker reduced (AUC p<0.0001)
🟢 高品質 ⚠️ 廠商資助 效應量:[object Object]
前往 PubMed
Assessment of Urolithin A effects on muscle endurance, strength, inflammation, oxidative stress, and protein metabolism in male athletes with resistance training
PMID: 39487653 2024 RCT (double-blind) n = 20
結論:Repetitions to failure improved vs placebo (p=0.011); MVIC improved vs placebo (p=0.048); CRP lower vs placebo (p=0.032); small sample (n=20) limits generalizability
🟠 品質有限
前往 PubMed

L4a US FDA
支持
FDA has no questions 來源↗
L4b EU EFSA
中性
In 2022, the European Food Safety Authority (EFSA) gave a positive opinion on the safety of Urolithin A for use in food supplements for the general adult population. The EFSA report emphasized no adverse effects under the proposed daily dose of up to 500 mg/day. 來源↗
L4c UK NHS
未表態
Application for the approval of Urolithin A as a novel food. Applicant: Amazentis SA. Status: In progress. Current Phase: Risk assessment In progress. [ACNFP 173rd meeting, 24-25 Sept 2025] The applicant proposes urolithin A in conventional foods, cereal bars, protein bars, nutrition bars targeting athletes, yoghurt products, specialised foods for adults only, including meal replacements, nutri… 來源↗
L4d TW TFDA / 衛福部
未表態
— 本適應症無對應資料
L4e WHO
支持
Urolithin A is a synthetic version of urolithin A of the compound formed endogenously following consumption of ellagic acid and ellagitannins. Urolithin A is manufactured via chemical synthesis involving a chemical reaction between 2-bromo-5-hydroxybenzoic acid and resorcinol in the presence of sodium hydroxide and catalyst of cupric sulfate pentahydrate, followed by protonation of the resultin… 來源↗

L5a NIH Office of Dietary Supplements
未表態
— 本適應症無對應資料
L5b Mayo Clinic
未表態
— 本適應症無對應資料
L5c Cleveland Clinic
未表態
— 本適應症無對應資料
L5d Harvard Health
未表態
— 本適應症無對應資料
L5e Specialty Society (condition-mapped)
未表態
— 本適應症無對應資料

PTT · Dcard · Mobile01 彙整自公開論壇討論,非統計抽樣,僅反映社群風向。
廣告 / 業配密度 極高
📍立場總覽

台灣社群(PTT 健身板/MuscleBeach/FITNESS/Supplement、Dcard、Mobile01、痞客邦、FB 社團)幾乎沒有「尿石素A 用於運動耐力」的真實鄉民實測心得。多輪搜尋僅命中商業 PR 稿(Business Wire/中央社訊息平台廠商發稿)、電商上架頁(Amazon Timeline Mitopure)與健康媒體/部落格科普文(康健大人社團、IQ健康網、思思醫師、大紀元、知乎、百度),屬 L10d 商業媒體範疇而非社群自發討論。鄉民在健身/重訓脈絡討論耐力與恢復時,主流仍是肌酸、咖啡因、beta-alanine、乳清等成分,尿石素A 在台灣健身圈尚屬冷門、能見度極低,本層無可萃取的在地使用經驗或迷思訊號。

💬社群實感

無共識(台灣 PTT/Dcard/Mobile01/痞客邦/FB 社團查無針對運動耐力的尿石素A 真實實測心得;現有能見度幾乎全來自廠商 PR 稿與科普媒體,非鄉民自發討論)

L10a · 廠商行銷話術 行銷語言
💬 通路如何宣傳

Timeline Urolithin A 60 軟膠囊 $2,899

代表來源 ↗
L10b · TFDA 法定身份 官方認定

本平臺非正面表列,並非平臺未載列品項即不得供為食品原料使用

來源 ↗

  • 規律有氧/耐力訓練
  • 訓練週期化與漸進負荷
PMID 100% 反查全部經 NCBI Entrez 驗證
🔬 4 篇 L2 文獻 經多層 sub-agent 獨立評估
🇹🇼 含台灣社群分析L10c PTT / Dcard / Mobile01
aggregated_at: 2026-06-01 claim_version: v6 engine_version: v1.0 claim_id: CLM-COND-endurance-INT-urolithin-a-001
查看 ClaimReview 結構化資料 (JSON-LD)
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