口服低劑量 Minoxidil Low-Dose Oral Minoxidil (LDOM)

INT-low-dose-oral-minoxidil-001 4 個適應症被研究
A 2 B 1 C 1

適應症與證據等級

法規與權威立場 (L4)

L4a · US FDA
立場:cautious
BOXED WARNING: 'Minoxidil tablets contain the powerful antihypertensive agent, minoxidil, which may produce serious adverse effects. It can cause pericardial effusion, occasionally progressing to tamponade, and angina pectoris may be exacerbated. Minoxidil must be administered under close supervision, usually concomitantly with therapeutic doses of a beta-adrenergic blocking agent to prevent ta…
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L4b · EU EFSA
立場:cautious
Minoxidil and its salts must not be used in cosmetic products because of their antihypertensive activity. Minoxidil absorption after scalp application could lead to systemic effects. [Minoxidil is] a peripheral vasodilatator acting on vascular smooth muscle cells, used as a drug in the management of severe hypertension. [The substance is] cardiotoxic in long term oral studies.
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L4c · UK NHS
立場:cautious
Minoxidil foam (Regain) is the only licensed treatment for female and male pattern hair loss. You will start on a 0.625mg dose on alternate days; any further changes to the dose will be discussed in your follow up consultations. While you are receiving minoxidil treatment you should have your pulse and blood pressure monitored regularly by your GP. This treatment is not advised for individuals …
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L4d · TW TFDA / 衛福部
立場:cautious
洛寧錠10毫克 LONITEN 10MG 衛署藥輸字 第 007538 號 須由醫師處方使用;目前口服 minoxidil 的適應症還是只有用在高血壓,用在治療落髮還是屬於適應症外用藥。
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L4e · WHO
立場:neutral
Minoxidil belongs to the drug class of direct-acting peripheral vasodilators. It exerts its antihypertensive effect by opening adenosine triphosphate (ATP)-sensitive potassium channels, thereby reducing peripheral resistance and lowering blood pressure. The FDA approved minoxidil in tablet form in 1979 under the brand name Loniten specifically for treatment of high blood pressure. Low-dose oral…
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市場與行銷 (L10)

L10a · TW Market Channels
洛寧錠10毫克 LONITEN 10MG 衛署藥輸字 第 007538 號 須由醫師處方使用
L10b · TW Legal Identity (TFDA)
洛寧錠10毫克 LONITEN 10MG 衛署藥輸字 第 007538 號 須由醫師處方使用 ... 適應症為嚴重高血壓,僅適用於治療嚴重高血壓 ... 用在治療落髮還是屬於適應症外用藥(off-label use)
L10c · TW Community (PTT/Dcard/Mobile01)
對圓禿比較有效果的是直接施打類固醇進頭皮和使用落建的Minoxidil 5%(米諾地爾);內用雖然方便但副作用真的比較多(頭痛、水腫)