神聖羅勒 Tulsi (Holy Basil) × 第二型糖尿病
結論：證據支持但有警示
證據屬薄弱級：機轉合理且方向一致顯示降血糖訊號，但人體實證僅靠 1996 年 Agrawal 單盲交叉小型 RCT（n≈40、4 週）與 Jamshidi 2018 統合分析（pooled FG -15.
C 🟠 C 薄弱證據 附警語發布 ⚠️ medium — moderate promotional content
證據屬薄弱級：機轉合理且方向一致顯示降血糖訊號，但人體實證僅靠 1996 年 Agrawal 單盲交叉小型 RCT（n≈40、4 週）與 Jamshidi 2018 統合分析（pooled FG -15.69 mg/dl 但 I²=91% 極端異質性、未被 PubMed 收錄），且全程缺乏 HbA1c 主要臨床終點。
2023 網絡統合分析更直接將聖羅勒排除在六種抗糖草藥之外，反映其證據基礎較肉桂、葫蘆巴更薄。
符合 C tier「機轉合理＋少量人體研究＋學會 insufficient evidence」錨點。
⚖️
評分透明度
所有分數由 7 層證據引擎計算，過程公開可查原始分數 0.55
D
C
B
A
S
← 反證據 / 無效有效 / 強證據 →
最終評級
C · 附警語發布
信心度
82%
證據方向一致性高
證據層級
E2
多篇高品質統合分析（≥2 篇一致）
▸查看完整決策路徑（audit trail）
- compute_raw_score — 加權公式: L2×0.30 + L3×0.25 + L5×0.25 + L11×0.10 + L1×0.10 = 0.547
- tier_from_score — 依分數區間映射至 tier letter
- apply_hec_rules — 高品質 SR/MA 顯示 positive (2 篇 > 0 negative)
- tier_strict_requirement_check — Tier 條件達標，未降階
- detect_disputes — 偵測到 0 個 hard + 0 個 soft dispute
- decide_status — 依 tier + dispute 結果決定 status
Randomized placebo-controlled, single blind trial of holy basil leaves in patients with noninsulin-dependent diabetes mellitus
結論：Classic crossover RCT in NIDDM: fasting blood glucose fell 21.0 mg/dl (17.6% reduction, p<0.001) and postprandial glucose fell 15.8 mg/dl (7.3% reduction, p<0.02) during holy basil treatment vs placebo; mild reduction in total cholesterol. Authors suggest basil leaves as adjunct to diet and drug therapy in mild-to-moderate NIDDM.
前往 PubMed
Holybasil (tulsi) lowers fasting glucose and improves lipid profile in adults with metabolic disease: A meta-analysis of randomized clinical trials
— 詳細結論請見 PubMed 原文
前往 PubMed
Effect of Tulsi (Ocimum sanctum Linn.) Supplementation on Metabolic Parameters and Liver Enzymes in Young Overweight and Obese Subjects
結論：Parallel open-label pilot RCT in young overweight/obese (non-diabetic) subjects: significant improvement in triglycerides (p=0.019), LDL (p=0.001), HDL (p=0.001), VLDL (p=0.019), BMI (p=0.005), plasma insulin (p=0.021) and insulin resistance/HOMA-IR (p=0.049); no adverse liver enzyme changes. Postprandial glucose and HbA1c not assayed.
前往 PubMed
Comparative effectiveness of six herbs in the management of glycemic status of type 2 diabetes mellitus patients: A systematic review and network meta-analysis of randomized controlled trials
結論：Network meta-analysis of 44 RCTs (3130 participants): apple cider vinegar, fenugreek, curcumin and cinnamon significantly reduced fasting glucose; only ACV and fenugreek reduced HbA1c. Ocimum sanctum / tulsi was NOT among the six herbs evaluated, so this MA provides no direct tulsi estimate but contextualises tulsi's evidence base as thinner than other antidiabetic herbs.
前往 PubMed
L5a NIH Office of Dietary Supplements
中性
— 本適應症無對應資料
L5b Mayo Clinic
中性
— 本適應症無對應資料
L5c Cleveland Clinic
中性
— 本適應症無對應資料
L5d Harvard Health
中性
— 本適應症無對應資料
L5e Specialty Society (condition-mapped)
反對
There is insufficient evidence to support the routine use of herbal supplements and micronutrients, such as cinnamon, curcumin (e.g., turmeric), aloe vera, or chromium, to improve glycemia in people with type 1 or type 2 diabetes. 來源↗
PTT · Dcard · Mobile01 彙整自公開論壇討論，非統計抽樣，僅反映社群風向。
廣告 / 業配密度 中度
低中高
📍立場總覽
台灣社群（PTT/Dcard/Mobile01/FB社團/痞客邦）幾乎無人以「神聖羅勒（圖爾西/聖羅勒/Tulsi）」討論第二型糖尿病或控制血糖。在地對此植物的認知集中於三類：泰式料理香草「打拋葉」（打拋肉非九層塔）、PTT 芳療版的精油用途、以及壓力/焦慮取向的進口草本茶（adaptogen）。降血糖相關內容幾乎都來自 FB 草本賣家、內容行銷型健康媒體與港陸/印度阿育吠陀文章，非台灣鄉民真實使用經驗。屬冷門、社群討論稀少，無法形成在地共識。
💬社群實感
無共識（台灣社群幾乎無針對第二型糖尿病/降血糖的真實使用心得，無法判定）
- 醫療營養治療與減重
- 規律身體活動
- Metformin（二甲雙胍）
查看 ClaimReview 結構化資料 (JSON-LD)
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