泛酸（維生素 B5） Vitamin B5 (Pantothenic acid) × 皮膚健康
結論：證據支持
必須區分劑型：外用 dexpanthenol（前維生素 B5）對皮膚屏障修復與術後表淺傷口癒合有中等品質的 RCT 與多篇回顧支持，但樣本小、僅短期表淺終點，且數篇關鍵回顧為 Bayer（Bepanthen）資助／作者從屬，存在顯著 COI——此外用證據約落在 C（薄弱～初步間）。
B 🟡 B 初步證據 已發布 ⚠️ medium — moderate promotional content
必須區分劑型：外用 dexpanthenol（前維生素 B5）對皮膚屏障修復與術後表淺傷口癒合有中等品質的 RCT 與多篇回顧支持，但樣本小、僅短期表淺終點，且數篇關鍵回顧為 Bayer（Bepanthen）資助／作者從屬，存在顯著 COI——此外用證據約落在 C（薄弱～初步間）。
口服泛酸用於『皮膚健康』則證據薄弱至缺乏：L1 Examine no_data、L5a NIH ODS 皮膚未提及、Mayo/Cleveland/Harvard/AAD 全部 not_addressed，唯一相關口服 RCT 為多成分抗痘配方無法歸因 B5。
綜合兩種劑型後給 C，且口服面向實質接近 U。
⚖️
評分透明度
所有分數由 7 層證據引擎計算，過程公開可查原始分數 0.61
D
C
B
A
S
← 反證據 / 無效有效 / 強證據 →
最終評級
B · 已發布
信心度
89%
證據方向一致性高
證據層級
E2
多篇高品質統合分析（≥2 篇一致）
▸查看完整決策路徑（audit trail）
- compute_raw_score — 加權公式: L2×0.30 + L3×0.25 + L5×0.25 + L11×0.10 + L1×0.10 = 0.613
- tier_from_score — 依分數區間映射至 tier letter
- apply_hec_rules — 高品質 SR/MA 顯示 positive (1 篇 > 0 negative)
- tier_strict_requirement_check — Tier 條件達標，未降階
- detect_disputes — 偵測到 0 個 hard + 0 個 soft dispute
- decide_status — 依 tier + dispute 結果決定 status
Topical use of dexpanthenol in skin disorders (Proksch & Nissen review)
結論：Reviews in vitro and clinical evidence that topical dexpanthenol improves stratum corneum hydration, reduces TEWL, and promotes wound healing; foundational support for topical use.
前往 PubMed
Dexpanthenol enhances skin barrier repair and reduces inflammation after SLS-induced irritation
結論：Dexpanthenol cream significantly accelerated barrier repair, increased hydration, reduced roughness and erythema vs placebo (p-values not in abstract).
前往 PubMed
Dexpanthenol in Wound Healing after Medical and Cosmetic Interventions (Postprocedure Wound Healing)
結論：Topical dexpanthenol significantly improved lesion-diameter reduction and re-epithelialization in one trial (n=38; p<0.05 and p<0.01); judged state-of-the-art for superficial postprocedure wounds.
前往 PubMed
Accelerated wound healing with a dexpanthenol-containing ointment after fractional ablative CO2 laser resurfacing
結論：Dexpanthenol ointment produced significantly faster lesion cure than petroleum jelly on days 1-2 post-resurfacing.
前往 PubMed
Use of Dexpanthenol for Atopic Dermatitis - Benefits and Recommendations Based on Current Evidence
結論：Concludes topical dexpanthenol improves barrier function, reduces flares and spares corticosteroids in mild-moderate AD; Bayer-affiliated authorship.
前往 PubMed
A Randomized, Double-Blind, Placebo-Controlled Study of a Pantothenic Acid-Based Dietary Supplement in Mild-Moderate Facial Acne
結論：Supplement reduced total lesions vs placebo (68.2% greater reduction; IGA success 42.9% vs 14.3%), but multi-ingredient formula limits attribution to B5 alone.
前往 PubMed
Safety and Effectiveness of Oral Nutraceuticals for Treating Acne: A Systematic Review
結論：Rates oral pantothenic acid as having only fair-quality evidence; not among interventions with good-quality support for acne, indicating weak/insufficient oral B5 evidence.
前往 PubMed
L4a US FDA
支持
CALCIUM PANTOTHENATE — CAS 137-08-6 — SCOGS no. 93 — 21 CFR 184.1212 — affirmed as Generally Recognized as Safe (GRAS) as a direct human food ingredient; used as a NUTRIENT SUPPLEMENT (including infant formula). 來源↗
L4b EU EFSA
支持
On the basis of the data presented, the Panel concludes that a cause and effect relationship has been established between the dietary intake of pantothenic acid and a normal energy-yielding metabolism, normal synthesis and metabolism of steroid hormones, vitamin D and some neurotransmitters, normal mental performance and the reduction of tiredness and fatigue. 來源↗
L4c UK NHS
謹慎
Pantothenic acid has several functions, such as helping our bodies release energy from food. Pantothenic acid is found in virtually all meat and vegetables... As pantothenic acid is found in a wide range of foods, it's unlikely that you'll not get enough of it. You should be able to get all the pantothenic acid you need by eating a varied and balanced diet. 來源↗
L4d TW TFDA / 衛福部
支持
泛酸之足夠攝取量(AI)成人為每日5.0毫克 來源↗
L4e WHO
未表態
— 本適應症無對應資料
L5a NIH Office of Dietary Supplements
支持
Because some pantothenic acid is present in almost all foods, deficiency is rare except in people with severe malnutrition. [...] The FNB was unable to establish ULs for pantothenic acid because there are no reports of pantothenic acid toxicity in humans at high intakes. [...] Pantothenic acid is not known to have any clinically relevant interactions with medications. 來源↗
L5b Mayo Clinic
未表態
— 本適應症無對應資料
L5c Cleveland Clinic
未表態
— 本適應症無對應資料
L5d Harvard Health
未表態
— 本適應症無對應資料
L5e Specialty Society (condition-mapped)
未表態
Supplements can be a good choice to help treat vitamin deficiencies or other conditions that require more nutrients in your body. 來源↗
PTT · Dcard · Mobile01 彙整自公開論壇討論，非統計抽樣，僅反映社群風向。
廣告 / 業配密度 中度
低中高
📍立場總覽
台灣社群討論集中在外用泛醇(B5)修護保濕，敏感肌口碑佳；但有人爆痘、反應分歧，口服泛酸討論極少。
💬社群實感
分歧（外用泛醇修護保濕多數正面，敏感肌好評；但有人反映悶痘/爆痘，效果因膚質而異；口服泛酸幾無社群討論）
破解迷思 社群最常見的 4 個誤解
✓
事實把外用泛醇(panthenol)與口服泛酸(pantothenic acid)混為一談，以為塗抹與吃下去效果相同
✓
事實「B5爆痘是先排毒、爆完就會好」的排毒/淨化(purging)迷思，實際多為保濕劑悶住毛孔誘發痘痘
✓
事實認為痘痘肌猛擦/多吃B5就能消痘，過度塗抹反而悶痘、與證據不符
✓
事實把外用B5當成可治療痤瘡的療效成分，誇大其抗痘功效
🩹 社群通報的副作用
- 悶痘 / 大爆痘（外用B5修護霜全臉使用，油痘肌尤甚）
- 部分人覺得太滋潤、悶、起小疹
- 口服高劑量泛酸偶有腸胃不適（社群罕見提及）
🏷️ 社群熱議品牌
依論壇被提及頻率，非銷售或品質排序。
- 理膚寶水 La Roche-Posay（B5 小藍瓶，社群王者地位）
- DR.WU（菸鹼醯胺B5舒緩精華）
- 達特醫 Dr.Hsieh
- The Ordinary（玻尿酸+B5）
- 寶拉珍選 Paula's Choice
⚠️ 列出僅代表「TW 社群討論度高」，不代表本站推薦或背書。本站不販售任何產品、無導購連結。
- 每日防曬（廣效、SPF 30 以上）
- 規律保濕與溫和清潔
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