聖潔莓 Chaste tree × 經前症候群
Evidence for Vitex agnus-castus standardised dry extract (Ze 440 / BNO 1095 / EFLA-665, ~20 mg/day for 3 cycles) for PMS symptom relief converges across multiple independent sources: Examine grades the canonical Premenstrual Syndrome: PMS Symptoms endpoint A (8 studies / 883 participants / Large Improvement) and Breast Tenderness A (4 studies / 405 participants / Moderate Improvement); PubMed shows 2 quality RCTs reproducing the effect across Western (Schellenberg 2001 BMJ n=170: 52% vs 24% improvement, p<0.
Evidence for Vitex agnus-castus standardised dry extract (Ze 440 / BNO 1095 / EFLA-665, ~20 mg/day for 3 cycles) for PMS symptom relief converges across multiple independent sources: Examine grades the canonical Premenstrual Syndrome: PMS Symptoms endpoint A (8 studies / 883 participants / Large Improvement) and Breast Tenderness A (4 studies / 405 participants / Moderate Improvement); PubMed shows 2 quality RCTs reproducing the effect across Western (Schellenberg 2001 BMJ n=170: 52% vs 24% improvement, p<0.001) and Chinese (He 2009 n=217) populations, with Van Die 2013 SR reporting 7/8 PMS RCTs positive and Verkaik 2017 pooled SMD ≈ -1.0; EMA/HMPC has issued a 'well-established use' herbal monograph (EMA/HMPC/606742/2017 Rev.1, 2018) recognising the 20 mg/day dry-extract preparation specifically for PMS in adult women — a relatively rare regulatory recognition for a botanical; WHO Monographs Vol.4 (2009) lists PMS under 'Uses supported by clinical data'; Cleveland Clinic (named MD reviewer Sobia Khan) affirms benefit. The cautious voices (ACOG CPG No.7 2023 'further study needed', NCCIH 'low-to-moderate quality', Mayo 'listed but not endorsed') reflect a higher evidence-bar threshold rather than counter-evidence — none disputes the direction of effect; they ask for larger/better-powered trials. I therefore grade A, matching Examine. The grade is held below S because (a) pivotal positive RCTs (Schellenberg Ze 440, He BNO 1095) are sponsored by botanical-drug manufacturers Zeller and Bionorica, (b) Verkaik 2017 reports very high heterogeneity (I² >90%) in the pooled SMD, (c) most trials only run ~12 weeks so long-term efficacy beyond 3-6 months is unstudied, and (d) ACOG/NCCIH/Mayo collectively decline to issue a positive recommendation despite the data being on the table.
評分透明度
所有分數由 7 層證據引擎計算，過程公開可查▸查看完整決策路徑（audit trail）
- compute_raw_score — 加權公式: L2×0.30 + L3×0.25 + L5×0.25 + L11×0.10 + L1×0.10 = 0.582
- tier_from_score — 依分數區間映射至 tier letter
- apply_hec_rules — 高品質 SR/MA 顯示 positive (1 篇 > 0 negative)
- tier_strict_requirement_check — Tier 條件達標，未降階
- detect_disputes — 偵測到 0 個 hard + 1 個 soft dispute
- decide_status — 依 tier + dispute 結果決定 status
台灣社群對聖潔莓緩解 PMS 的真實討論偏少且分散：PTT 香氛板（Aromatherapy）與 TWproducts 板各有一篇深度親身心得（GNC 膠囊 2 顆/日、miss seesaw 月月私語精華飲），均回饋週期變規律、胸部脹痛／經前痛／經前痘減輕，且第三個月才明顯見效、停藥後一週症狀復發；個人實測多偏正面但 n 極少，無法視為證據。整體版面被大量保健品廠商業配文（亞尼活力、昂萃、苼莛、goodbody、formulawave 等）與『天然黃體素／調經聖品』affiliate 內容淹沒，真實鄉民辯證稀薄，business 污染嚴重。
多數正面但討論量少（少數深度親身心得回饋週期變規律、經前胸脹／腰痛／經前痘改善，第 2-3 個月見效、停藥後症狀復發；惟樣本極少且多為產品試用文）
- 初次食用胃部輕微不適／噁心
- 頭痛
- 月經提早來或經期週期暫時紊亂
- 經期結束頭兩天長小痘子（經前痘）
- 停藥後一週內 PMS 症狀（腰痛、胸部脹痛）快速復發
依論壇被提及頻率，非銷售或品質排序。
- GNC 貞節樹果／聖潔莓膠囊（PTT 香氛板深度心得使用，週期規律化）
- iHerb 代購 NOW Foods Chaste Berry Vitex 300mg（鄉民最常自行採購之國際品牌）
- iHerb 代購 Nature's Way Vitex Fruit 400mg
- iHerb 代購 Solaray Vitex 系列
- miss seesaw 月月私語精華飲（含聖潔莓的台製機能飲，PTT TWproducts 板熱議）
- 亞尼活力／昂萃／苼莛等台廠聖潔莓膠囊（業配與部落格大量推播）
⚠️ 列出僅代表「TW 社群討論度高」，不代表本站推薦或背書。本站不販售任何產品、無導購連結。
- 選擇性血清素回收抑制劑（SSRI）
- 複方口服避孕藥（含 drospirenone 24+4 劑型）
- 認知行為治療（CBT）
查看 ClaimReview 結構化資料 (JSON-LD)
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