聖潔莓 Chaste tree × 多囊性卵巢症候群
結論：證據分歧
PCOS-specific 證據薄弱：僅 1 個 placebo-controlled RCT (PMID 41428718, n=60)，其餘 RCT 為 active-comparator 設計（vs metformin、vs LD-OCP），製劑劑量差異大且全為伊朗單中心中等品質試驗；機轉外推自 PMS/hyperprolactinaemia 屬合理但未充分驗證。
C 🟠 C 薄弱證據 證據分歧 ⚠️ medium — moderate promotional content
PCOS-specific 證據薄弱：僅 1 個 placebo-controlled RCT (PMID 41428718, n=60)，其餘 RCT 為 active-comparator 設計（vs metformin、vs LD-OCP），製劑劑量差異大且全為伊朗單中心中等品質試驗；機轉外推自 PMS/hyperprolactinaemia 屬合理但未充分驗證。
Examine 完全未收錄 PCOS（PMS 為 A grade 不可外推）；ASRM 2023 國際 PCOS 指引、Endocrine Society、Harvard、Mayo PCOS 頁面、NCCIH 全部對 Vitex × PCOS 未表態；WHO 適應症列表亦未含 PCOS；ASRM 唯一具名背書之植物性輔助為 inositol。
屬「機轉合理 + 少量初步人體研究 + 學會集體沉默」之 C tier。
⚖️
評分透明度
所有分數由 7 層證據引擎計算，過程公開可查原始分數 0.48
D
C
B
A
S
← 反證據 / 無效有效 / 強證據 →
最終評級
C · 證據分歧
信心度
67%
證據方向大致一致
證據層級
E3
單篇高品質統合分析
▸查看完整決策路徑（audit trail）
- compute_raw_score — 加權公式: L2×0.30 + L3×0.25 + L5×0.25 + L11×0.10 + L1×0.10 = 0.485
- tier_from_score — 依分數區間映射至 tier letter
- apply_hec_rules — 無高階證據可裁決
- tier_strict_requirement_check — Tier 條件達標，未降階
- detect_disputes — 偵測到 1 個 hard + 0 個 soft dispute
- decide_status — 依 tier + dispute 結果決定 status
The Effect of Vitex Agnus-Castus Plant on Some Markers of Oxidative Stress, Lipid Profile and Insulin Resistance in Women with Polycystic Ovary Syndrome: A Randomized, Double-Blind Controlled Clini…
結論：Vitex significantly increased total antioxidant capacity (effect 13.01, p<0.05) and glutathione peroxidase (3.35, p<0.05), increased HDL (5.74, p<0.05), decreased oxidative stress index (-9.30, p<0.05) and HOMA-IR (-0.31, p<0.05), and improved menstrual frequency (3.51, p<0.05) vs placebo.
前往 PubMed
Comparing the Effects of Agnugol and Metformin on Oligomenorrhea in Patients with Polycystic Ovary Syndrome: A Randomized Clinical Trial
結論：Agnugol and metformin showed comparable effects on menstrual cycle regulation, menstruation length and pad use in PCOS-related oligomenorrhea; metformin group reported substantially more adverse effects (loss of appetite, nausea, vomiting) vs none in Agnugol group. Specific p-values not reported in abstract.
前往 PubMed
A comprehensive review of clinical studies with herbal medicine on polycystic ovary syndrome (PCOS)
結論：Review concludes Vitex agnus-castus can impact menstrual and ovulatory dysfunctions in PCOS; included RCTs report comparable efficacy to metformin (oligomenorrhea) and to low-dose OCPs (menstrual normalization, prolactin, free testosterone), with better tolerability. Authors stress further high-quality trials needed.
前往 PubMed
Herbal medicine for the management of polycystic ovary syndrome (PCOS) and associated oligo/amenorrhoea and hyperandrogenism; a review of the laboratory evidence for effects with corroborative clin…
結論：Across reviewed clinical studies, herbal interventions including Vitex agnus-castus reduced luteinising hormone, prolactin, fasting insulin and testosterone; evidence for regulation of ovulation, improved metabolic hormone profile and improved fertility outcomes in PCOS. Vitex equivalent to bromocriptine for prolactin lowering. Per-Vitex PCOS sample sizes not isolated in abstract.
前往 PubMed
The Effects of Combined Low-Dose Oral Contraceptives and Vitex Agnus on the Improvement of Clinical and Paraclinical Parameters of Polycystic Ovarian Syndrome: A Triple-Blind, Randomized, Controlle…
— 詳細結論請見 PubMed 原文
前往 PubMed
L4a US FDA
謹慎
Doctors use Vitex [an ingredient in FertilHerb for Women] to treat mild endometriosis or prevent its advancement. It has also been effective in treating amenorrhea, which is the lack of menstruation, as well as irregular menstruation, which can hinder fertility greatly. 來源↗
L4b EU EFSA
謹慎
L4c UK NHS
未表態
— 本適應症無對應資料
L4d TW TFDA / 衛福部
中性
西洋牡荊（外文名稱 Chaste Berry，學名 Vitex agnus-castus L.）列於食藥署「可供食品使用原料彙整一覽表」，分類為草、木本植物類（1），使用部位為果實；備註欄無特殊使用限量或警語。本平台非屬正面表列，未列載者亦非不得作為食品原料使用。 來源↗
L4e WHO
支持
Uses supported by clinical data: Orally for the symptomatic treatment of gynaecological disorders including corpus luteum insufficiency and hyperprolactinaemia, premenstrual syndrome, menstrual irregularities, cyclic mastalgia and also to treat hormonally-induced acne. Contraindications: Fructus Agni Casti should not be used during pregnancy. Nursing mothers: ...the use of the crude drug by nur… 來源↗
L5a NIH Office of Dietary Supplements
謹慎
L5b Mayo Clinic
未表態
— 本適應症無對應資料
L5c Cleveland Clinic
中性
L5d Harvard Health
未表態
— 本適應症無對應資料
L5e Specialty Society (condition-mapped)
未表態
PTT · Dcard · Mobile01 彙整自公開論壇討論，非統計抽樣，僅反映社群風向。
廣告 / 業配密度 中度
低中高
📍立場總覽
針對「多囊性卵巢症候群」面向，台灣社群討論幾乎全集中在 PTT 好孕版（GoodPregnan）與芳療版，且框架是「備孕／調經」而非把多囊當疾病治療。最常見的用法是「肌醇＋聖潔莓」併用補黃體、求穩定週期，少數人回饋吃 3 個月後週期變準甚至自然受孕，但同樣多人反映「初期週期更亂、月經延遲甚至不來」、吃肌醇脹奶腹痛而停用。版友普遍把聖潔莓當「天然黃體素」，並常與真正有多囊證據的肌醇混為一談。整體實測反應分歧、無正面共識，且常被導向「先看婦產科、別只靠保健品」。
💬社群實感
分歧（部分人吃 3～6 個月後週期變準、少數自然受孕回報正面；同樣多人反映初期週期更亂、月經延遲或不來、無明顯改善，且常與肌醇併用而難以歸因；無多囊療效正面共識）
破解迷思 社群最常見的 5 個誤解
✓
事實誤以為聖潔莓是「天然黃體素」可直接補充黃體素／提高黃體酮（實際機轉主要是作用於腦下垂體降低泌乳素，並非外源性黃體素，亦非直接補荷爾蒙）
✓
事實誤以為聖潔莓能「治多囊」或讓多囊排卵恢復正常（多囊證據薄弱，臨床證據主要在經前症候群 PMS／經前乳房脹痛，並非 PCOS 適應症）
✓
事實把聖潔莓與肌醇（Inositol）的功效混為一談（有 PCOS 臨床證據的是肌醇，聖潔莓無；社群常兩者併吃而把功勞歸給聖潔莓）
✓
事實誤以為聖潔莓可取代黃體素安胎或荷爾蒙治療（社群與醫師皆否定，懷孕後應停用）
✓
事實誤以為「吃越久／劑量越高越有效、月經一直拖代表在調理」（實際長期不停可能導致月經延遲甚至不來，經前數日宜停）
🩹 社群通報的副作用
- 月經延遲、週期變亂甚至不來月經（最常被提及，尤其長期不停吃）
- 胃部輕微不適、噁心、腸胃不適
- 乳房脹痛（與併用肌醇時亦有人反映脹奶、下腹抽痛）
- 輕微皮疹搔癢、口乾、眼睛乾（少數）
🏷️ 社群熱議品牌
依論壇被提及頻率，非銷售或品質排序。
- 紐萊特 Newtrition（社群常見「肌醇＋聖潔莓」備孕多囊組合）
- miss seesaw 月月私語（聖潔莓精華飲，TWproducts 版心得）
- Nature's Way（iHerb 海外代購，聖潔莓膠囊常見規格）
- NOW Foods / Solaray（iHerb 代購，貞節樹果 Vitex 膠囊）
⚠️ 列出僅代表「TW 社群討論度高」，不代表本站推薦或背書。本站不販售任何產品、無導購連結。
- 健康生活型態與體重管理
- 複方口服避孕藥
- Metformin（二甲雙胍）
查看 ClaimReview 結構化資料 (JSON-LD)
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