桑葉萃取物 Mulberry Leaf Extract × 非酒精性脂肪肝
Every NAFLD-specific efficacy datum for mulberry leaf / DNJ comes from rodent HFD/db-db models or FFA/palmitate-induced HepG2 cells (4 animal + 1 in vitro), and L2 reports human_rct_count = 0.
Every NAFLD-specific efficacy datum for mulberry leaf / DNJ comes from rodent HFD/db-db models or FFA/palmitate-induced HepG2 cells (4 animal + 1 in vitro), and L2 reports human_rct_count = 0. The direction is consistent (reduced hepatic lipid, lower ALT/AST), but there is a complete translational gap: no human NAFLD-endpoint trial (liver fat %, fibrosis, or ALT/AST as a primary clinical outcome) exists, and one of the five studies (PMID 34035824) is actually an alcoholic-liver model, not NAFLD. Examine does not index NAFLD for this plant at all (insufficient_data), and every authority — FDA/EFSA/NHS/WHO, Mayo/Cleveland/Harvard, and AASLD/AGA — is silent or not_addressed, with AASLD 2023 recommending only vitamin E and pioglitazone. Animal-plus-mechanism with zero human evidence is the textbook definition of an unverified (U) pairing; a C grade would over-credit preclinical consistency.
評分透明度
所有分數由 7 層證據引擎計算，過程公開可查▸查看完整決策路徑（audit trail）
- compute_raw_score — 加權公式: L2×0.30 + L3×0.25 + L5×0.25 + L11×0.10 + L1×0.10 = 0.44
- tier_from_score — 依分數區間映射至 tier letter
- apply_hec_rules — 僅有 E10 級證據 (cohort/animal/mechanism)，不足以下結論
- tier_strict_requirement_check — C 級條件未達 (需 E1-E8；實際 E10 僅機轉)
- detect_disputes — 偵測到 0 個 hard + 0 個 soft dispute
- decide_status — 依 tier + dispute 結果決定 status
台灣社群（PTT regimen/WomenTalk、Dcard、Mobile01）幾乎無人將桑葉萃取與非酒精性脂肪肝連結；脂肪肝討論集中於減重、紅麴、納豆與運動，桑葉則被歸類為降血糖/減醣或降體脂用途，無針對 NAFLD 的實測心得。
無共識（社群對桑葉萃取用於非酒精性脂肪肝幾乎無相關討論）
- 減重（飲食調整與運動）
- 地中海飲食型態
- 減少或戒除酒精
查看 ClaimReview 結構化資料 (JSON-LD)
{
"@context": "https://schema.org",
"@type": "ClaimReview",
"url": "https://gpt-dict.com/claim/CLM-COND-nafld-INT-mulberry-leaf-extract-001/",
"datePublished": "2026-06-01",
"author": {
"@type": "Organization",
"name": "gpt-dict.com",
"url": "https://gpt-dict.com"
},
"claimReviewed": "桑葉萃取物能改善非酒精性脂肪肝",
"inLanguage": "zh-TW",
"itemReviewed": {
"@type": "Claim",
"appearance": []
},
"reviewRating": {
"@type": "Rating",
"alternateName": "證據不足 (Insufficient evidence)"
}
}