維生素 B1（硫胺 / 硫胺素 / Thiamine） Vitamin B1 (Thiamine) × 疲勞 / 倦怠
結論：證據支持
三方一致 + 證據鏈足夠 + 無分歧
C 🟠 C 薄弱證據 已發布 ⚠️ medium — moderate promotional content
⚖️
評分透明度
所有分數由 7 層證據引擎計算，過程公開可查原始分數 0.44
D
C
B
A
S
← 反證據 / 無效有效 / 強證據 →
最終評級
C · 已發布
信心度
88%
證據方向一致性高
證據層級
E6
多篇較小型隨機對照試驗
▸查看完整決策路徑（audit trail）
- compute_raw_score — 加權公式: L2×0.30 + L3×0.25 + L5×0.25 + L11×0.10 + L1×0.10 = 0.44
- tier_from_score — 依分數區間映射至 tier letter
- apply_hec_rules — 無高階證據可裁決
- tier_strict_requirement_check — Tier 條件達標，未降階
- detect_disputes — 偵測到 0 個 hard + 0 個 soft dispute
- decide_status — 依 tier + dispute 結果決定 status
Randomised clinical trial: high-dose oral thiamine versus placebo for chronic fatigue in patients with quiescent inflammatory bowel disease
結論：Crossover analysis: mean fatigue reduction 4.5 points (95% CI 2.6-6.2) on thiamine vs +0.75 on placebo, p=0.0003.
前往 PubMed
High-dose oral thiamine versus placebo for chronic fatigue in patients with primary biliary cholangitis: A crossover randomized clinical trial
結論：Crossover analysis: fatigue +0.3 points on thiamine vs -1.4 on placebo, p=0.55; thiamine not superior to placebo.
前往 PubMed
Thiamine and Hashimoto's thyroiditis: a report of three cases
結論：Partial-to-complete regression of fatigue within hours-to-days in 3 euthyroid Hashimoto patients (no control, no p-value).
前往 PubMed
L4a US FDA
支持
NUTRIENT SUPPLEMENT 來源↗
L4b EU EFSA
支持
a cause and effect relationship has been established between the dietary intake of thiamine and (a) contribution to normal energy-yielding metabolism, (b) contribution to normal neurological function, and (c) contribution to normal function of the heart. 來源↗
L4c UK NHS
謹慎
Thiamin (vitamin B1) helps: the body break down and release energy from food; keep the nervous system healthy. Adults aged 19 to 64 need about: 1mg a day of thiamin for men; 0.8mg a day of thiamin for women. You should be able to get all the thiamin you need from your daily diet. Thiamin cannot be stored in the body, so you need it in your diet every day. 來源↗
L4d TW TFDA / 衛福部
支持
維生素B1有助於維持能量正常代謝；維生素B1有助於維持皮膚、心臟及神經系統的正常功能；維生素B1有助於維持正常生長 來源↗
L4e WHO
支持
Thiamine hydrochloride. Injection: 100 mg/mL in 1‑mL ampoule. Tablet: 50 mg (hydrochloride). — listed under 'Vitamins and minerals', WHO Model List of Essential Medicines. 來源↗
L5a NIH Office of Dietary Supplements
支持
Because of the lack of reports of adverse effects from high thiamin intakes (50 mg/day or more) from food or supplements, the FNB did not establish ULs for thiamin. Thiamin deficiency can cause loss of weight and appetite, confusion, memory loss, muscle weakness, and heart problems. 來源↗
L5b Mayo Clinic
未表態
— 本適應症無對應資料
L5c Cleveland Clinic
未表態
— 本適應症無對應資料
L5d Harvard Health
未表態
— 本適應症無對應資料
L5e Specialty Society (condition-mapped)
未表態
— 本適應症無對應資料
PTT · Dcard · Mobile01 彙整自公開論壇討論，非統計抽樣，僅反映社群風向。
廣告 / 業配密度 中度
低中高
📍立場總覽
B1多以B群/合利他命形式討論，社群反應分歧：熬夜族覺得提神有感，也不少人吃了只覺尿變黃無感，普遍認知B1是輔酶而非能量本身。
💬社群實感
分歧（熬夜/勞累族多反映合利他命、含TTFD配方提神有感；單純B群不少人覺得僅尿變黃、無明顯效果）
破解迷思 社群最常見的 5 個誤解
✓
事實以為B群/B1本身能直接提供能量，其實B1只是醣類代謝的輔酶，不是能量來源
✓
事實以為吃完尿變黃代表吸收好，實際黃色多來自B2或人工色素，非吸收指標
✓
事實以為劑量越高越有效，B群為水溶性過量會隨尿排出
✓
事實以為B群一律不能晚上吃會睡不著，適量補充反而有人覺得不影響甚至有助睡眠
✓
事實把疲勞一律歸因缺B1，忽略睡眠不足與飲食才是主因
🩹 社群通報的副作用
- 尿液變黃（最常被提及，多為色素或B2，非真副作用）
- 晚上服用影響睡眠 / 睡不著
- 腸胃不適、反胃（建議改緩釋型）
- 高劑量B6長期可能神經不適（少數提及）
🏷️ 社群熱議品牌
依論壇被提及頻率，非銷售或品質排序。
- 合利他命（アリナミン，含TTFD B1誘導體，Costco熱門）
- 決醒對策（含TTFD B1）
- 克補B群+鋅（Costco平價）
- DHC維他命B群
- Life Extension Two Per Day
- iHerb 平價綜合B群
⚠️ 列出僅代表「TW 社群討論度高」，不代表本站推薦或背書。本站不販售任何產品、無導購連結。
- 運動（有氧／阻力訓練）
- 認知行為治療（CBT）
- 正念為基礎的介入
查看 ClaimReview 結構化資料 (JSON-LD)
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