維生素 K Vitamin K × 心血管疾病
結論：證據不足
raw score=D 但缺乏實質「主流主動反對」訊號 (L11 grade=U, L5 against=1, L4 against=0, HEC=HEC-NONE) — 改 route 為「證據不足」
D 🔴 D 反證據 證據不足 🚨 high — heavy affiliate marketing in TW community
⚖️
評分透明度
所有分數由 7 層證據引擎計算，過程公開可查原始分數 0.39
D
C
B
A
S
← 反證據 / 無效有效 / 強證據 →
最終評級
D · 證據不足
信心度
85%
證據方向一致性高
證據層級
E2
多篇高品質統合分析（≥2 篇一致）
▸查看完整決策路徑（audit trail）
- compute_raw_score — 加權公式: L2×0.30 + L3×0.25 + L5×0.25 + L11×0.10 + L1×0.10 = 0.385
- tier_from_score — 依分數區間映射至 tier letter
- apply_hec_rules — 無高階證據可裁決
- tier_strict_requirement_check — Tier 條件達標，未降階
- detect_disputes — 偵測到 0 個 hard + 1 個 soft dispute
- decide_status — 依 tier + dispute 結果決定 status
Dietary intake of menaquinone is associated with a reduced risk of coronary heart disease: the Rotterdam Study
結論：Highest tertile of dietary menaquinone (K2) intake associated with lower CHD mortality (RR 0.43, 95% CI 0.24-0.77) and reduced severe aortic calcification vs lowest tertile; no association seen for phylloquinone (K1).
前往 PubMed
Menaquinone-7 supplementation improves arterial stiffness in healthy postmenopausal women. A double-blind randomised clinical trial
結論：MK-7 significantly reduced cfPWV and Stiffness Index β vs placebo over 3 years (most pronounced in women with baseline Stiffness Index β > median 10.8); dp-ucMGP fell ~50% confirming biochemical activity. Surrogate endpoints only — no hard CV outcomes.
前往 PubMed
Slower Progress of Aortic Valve Calcification With Vitamin K Supplementation: Results From a Prospective Interventional Proof-of-Concept Study
結論：Vitamin K1 arm showed slower AVC progression than placebo in this small open-label proof-of-concept trial (n=99 enrolled, 72 completed); 27% dropout, no ITT analysis presented. Hypothesis-generating only — not confirmed by larger AVADEC trial.
前往 PubMed
Vitamin K2 and D in Patients With Aortic Valve Calcification: A Randomized Double-Blinded Clinical Trial
結論：AVADEC trial: no significant difference in AVC progression (intervention +275 AU vs placebo +292 AU, between-group diff 17 AU, P=0.64) despite confirmed biochemical effect. Coronary calcification progression also not significantly slowed. Negative for primary endpoint.
前往 PubMed
Vitamin K supplementation and vascular calcification: a systematic review and meta-analysis of randomized controlled trials
結論：Pooled across 14 RCTs (n=1533) vitamin K modestly slowed CAC progression (MD -17.37 AU, 95% CI -34.18 to -0.56, P=0.04) and lowered dp-ucMGP (MD -243.31, P=0.0001). Effect on CAC is small, marginal, surrogate-only; no hard CV event outcome pooled.
前往 PubMed
The effect of vitamin K supplementation on cardiovascular risk factors: a systematic review and meta-analysis
結論：Across 17 RCTs only HOMA-IR improved with vitamin K (WMD -0.24, 95% CI -0.49 to -0.02, P=0.047); no significant effect on anthropometrics, CRP, glucose, or lipid panel. K2 subgroup slightly stronger on insulin resistance than K1. No hard CV outcomes assessed.
前往 PubMed
L4a US FDA
支持
Vitamin K1 Injection is indicated for prophylaxis and treatment of vitamin K-deficiency bleeding in neonates 來源↗
L4b EU EFSA
支持
a cause and effect relationship has been established between the dietary intake of vitamin K and normal blood coagulation ... and the maintenance of normal bone 來源↗
L4c UK NHS
謹慎
You should be able to get all the vitamin K you need by eating a varied and balanced diet. Any vitamin K your body does not need immediately is stored in the liver for future use, so you do not need it in your diet every day. 來源↗
L4d TW TFDA / 衛福部
支持
成年男性 120 微克／日，女性 90 微克／日（足夠攝取量 AI） 來源↗
L4e WHO
支持
vitamin K1 should be given to all newborns as a single, intramuscular dose of 0.5–1 mg 來源↗
L5a NIH Office of Dietary Supplements
支持
Vitamin K, the generic name for a family of compounds with a common chemical structure of 2-methyl-1,4-naphthoquinone, is a fat-soluble vitamin 來源↗
L5b Mayo Clinic
謹慎
Clinical trials have not shown any evidence that vitamin K supplements can slow calcium deposits in artery walls. 來源↗
L5c Cleveland Clinic
謹慎
Vitamin K may even reduce your risk of cardiovascular disease and death. 來源↗
L5d Harvard Health
中性
Vitamin K is involved with the production of matrix Gla proteins (MGP), which help to prevent calcification or hardening of heart arteries 來源↗
L5e Specialty Society (condition-mapped)
反對
Vitamin K2 and vitamin D supplements did not slow the progression of calcium deposits on the aortic valves. 來源↗
PTT · Dcard · Mobile01 彙整自公開論壇討論，非統計抽樣，僅反映社群風向。
廣告 / 業配密度 極高
低中高
📍立場總覽
台灣社群幾乎不單獨討論維生素K治心血管，多把K2(MK-7)當補鈣配角(鈣鎂D黃金組)，心血管/防鈣化僅作次要賣點，缺乏實測療效心得，業配評比文密集。
💬社群實感
無共識（社群多在骨骼/補鈣脈絡提到K2，鮮少有人為心血管疾病服用並回報實際療效）
破解迷思 社群最常見的 4 個誤解
✓
事實維生素K2能逆轉或溶解既有的血管鈣化/動脈硬化（誇大，臨床證據僅見動脈彈性指標小幅改善）
✓
事實吃K2就能放心補鈣不會鈣化、可取代就醫與正規治療
✓
事實混淆K1與K2，以為多吃綠葉蔬菜的K1就有護血管效果
✓
事實心血管病人服用抗凝血劑也能隨意補K2（實際上會干擾Warfarin療效，屬禁忌）
🩹 社群通報的副作用
- 社群幾乎無自述副作用（K2 普遍認為耐受性佳）
- 主要被提醒的是與Warfarin(可邁丁)等抗凝血劑的交互作用風險
🏷️ 社群熱議品牌
依論壇被提及頻率，非銷售或品質排序。
- 大醫生技
- VITABOX
- 悠活原力
- 德風健康館
- MenaQ7/ Menatto 日本MK-7 配方款（多為複方鈣D3）
- iHerb 直購（Now Foods / Doctor's Best 等）
⚠️ 列出僅代表「TW 社群討論度高」，不代表本站推薦或背書。本站不販售任何產品、無導購連結。
- 生活型態優化（健康飲食、身體活動、戒菸）
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- 戒菸（行為介入合併藥物）
查看 ClaimReview 結構化資料 (JSON-LD)
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