紫檀芪 Pterostilbene × 老化
結論：台灣市場資訊黑箱
紫檀芪用於人類「老化／延壽」終點的證據近乎為零：唯一人體 RCT（Riche 2014, n=80, 6-8 週）僅測代謝替代指標，並非老化生物標記、healthspan 或壽命終點，且暴露 LDL +17.
U ⚫ U 未驗證 台灣法規禁言 🚨 high — heavy affiliate marketing in TW community
紫檀芪用於人類「老化／延壽」終點的證據近乎為零：唯一人體 RCT（Riche 2014, n=80, 6-8 週）僅測代謝替代指標，並非老化生物標記、healthspan 或壽命終點，且暴露 LDL +17.1 mg/dL (p=0.001) 的安全性訊號；其餘證據為兩篇敘述性綜述加上果蠅壽命與大鼠基因表現之動物模型，無 meta-analysis、無人體老化終點 RCT。
Examine 在 'Aging' 條目下找不到紫檀芪（found_in_examine=false），Mayo/Cleveland/Harvard 三大醫學中心對 pterostilbene-aging 完全未表態，AFAR/GSA/AGS 三大老化學會均無背書（GSA 旗艦期刊明白指出 NAD+ 前驅物類別僅有有限、未驗證之功能改善訊號）。
EU 列為未授權 Novel Food、台灣食藥署視為藥用成分禁止商業販售，FDA 僅 self-affirmed GRAS 而非官方 GRN。
整體屬「機轉合理但無人體老化終點驗證」之 Tier U（未驗證），不可升至 C（薄弱證據），因 Riche 2014 並非老化研究而是血脂／血壓研究。
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評分透明度
所有分數由 7 層證據引擎計算，過程公開可查原始分數 0.40
D
C
B
A
S
← 反證據 / 無效有效 / 強證據 →
最終評級
U · 台灣法規禁言
信心度
72%
證據方向大致一致
證據層級
E2
多篇高品質統合分析（≥2 篇一致）
▸查看完整決策路徑（audit trail）
- compute_raw_score — 加權公式: L2×0.30 + L3×0.25 + L5×0.25 + L11×0.10 + L1×0.10 = 0.403
- tier_from_score — 依分數區間映射至 tier letter
- apply_hec_rules — 無高階證據可裁決
- tier_strict_requirement_check — | C→U 因 scope.conflation_risk=true 且 L11 獨評較低 (B7-2 tier cap)
- detect_disputes — 偵測到 0 個 hard + 0 個 soft dispute
- decide_status — 依 tier + dispute 結果決定 status
Pterostilbene on Metabolic Parameters: A Randomized, Double-Blind, and Placebo-Controlled Trial
結論：High-dose pterostilbene reduced SBP by 7.8 mmHg (p<0.01) and DBP by 7.3 mmHg (p<0.001); LDL rose with monotherapy (+17.1 mg/dL, p=0.001), attenuated by grape extract; minor weight loss in subjects not on statins (-0.62 kg/m^2, p=0.012). Only human RCT to date.
前往 PubMed
Unlocking the therapeutic potential of natural stilbene: Exploring pterostilbene as a powerful ally against aging and cognitive decline
結論：Concludes pterostilbene is a robust mechanistic candidate against age-related cardiovascular disease, diabetes, and cognitive decline; explicitly states human clinical validation remains lacking.
前往 PubMed
Effect of resveratrol and pterostilbene on aging and longevity
結論：Both stilbenes show preclinical anti-aging signals via modulation of aging hallmarks; pterostilbene noted for higher bioavailability than resveratrol but human longevity data absent.
前往 PubMed
Pterostilbene Targets Hallmarks of Aging in the Gene Expression Landscape in Blood of Healthy Rats
結論：Pterostilbene shifts blood transcriptome toward downregulation of pathways tied to genomic instability, epigenetic alterations, impaired autophagy, mitochondrial dysfunction, deregulated nutrient sensing, altered intercellular signaling, and loss of proteostasis (adjusted p<=0.05). Provides rationale for human longevity trials.
前往 PubMed
Pterostilbene Promotes Mean Lifespan in Both Male and Female Drosophila Melanogaster Modulating Different Proteins in the Two Sexes
結論：Lifelong PTS supplementation increased mean lifespan in both sexes, with stronger effect in females; sex-divergent proteomic response (113 proteins modulated in males vs 9 in females; vacuolar H+ ATPase common).
前往 PubMed
L4a US FDA
謹慎
There were no records found that match your search criteria in this inventory. 來源↗
L4b EU EFSA
謹慎
Pterostilbene (Pterocarpus santalinus) extract (≥ 99%) ... assessed as novel and not authorized for use in food or food supplements unless a pre-market novel food authorisation is granted. 來源↗
L4c UK NHS
未表態
— 本適應症無對應資料
L4d TW TFDA / 衛福部
未表態
— 本適應症無對應資料
L4e WHO
謹慎
Pterostilbene — CAS 537-42-8 — listed in Health Canada Natural Health Products Ingredients Database (NHPID) as an approved Schedule 1 'isolate' ingredient; source organism cited as Pterocarpus marsupium (stem heartwood). Multiple NPN-licensed products in the LNHPD (e.g. Nutracentials Blueberry Pterostilbene NX, NPN 80052455, containing pTeroPure® pterostilbene 25 mg; Ensonkan NMN+PQQ+Pterostilb… 來源↗
L5a NIH Office of Dietary Supplements
謹慎
L5b Mayo Clinic
未表態
— 本適應症無對應資料
L5c Cleveland Clinic
未表態
— 本適應症無對應資料
L5d Harvard Health
未表態
— 本適應症無對應資料
L5e Specialty Society (condition-mapped)
謹慎
Only limited data from select studies have found clinically relevant improvements to physiological function after treatment with these NAD+-boosting supplements. 來源↗
PTT · Dcard · Mobile01 彙整自公開論壇討論，非統計抽樣，僅反映社群風向。
廣告 / 業配密度 極高
低中高
📍立場總覽
台灣社群（PTT/Dcard/Mobile01/痞客邦）幾乎無紫檀芪用於抗老的真實討論。多輪搜尋僅命中香港保健品電商部落格（s-cell、nupharm、rejuve）、直銷/MLM 頁面（美商惟哇 viiva）與 SEO 業配型健康內容站（營養新知 formulawave），並無鄉民實測心得、品牌討論或副作用回報；少數標榜「PTT/Dcard/Mobile01」字樣的頁面實為借論壇名引流的推薦清單，內容與紫檀芪抗老無關。台灣食藥署將紫檀芪歸為藥用成分、無合法上市保健品，連帶使本地社群幾無在地產品可討論。屬冷門、無社群訊號之有效結果。
💬社群實感
無共識（台灣社群幾無紫檀芪抗老的真實使用心得）
- 規律身體活動（有氧、肌力與平衡訓練）
- 戒菸
查看 ClaimReview 結構化資料 (JSON-LD)
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