S-腺苷甲硫胺酸 SAMe × 骨關節炎
The single strongest piece of evidence is the 2009 Cochrane review (4 placebo-controlled trials, 656 patients), which found SAMe no better than placebo for pain (SMD -0.
The single strongest piece of evidence is the 2009 Cochrane review (4 placebo-controlled trials, 656 patients), which found SAMe no better than placebo for pain (SMD -0.17, 95% CI -0.34 to 0.01, crossing zero) and essentially no functional benefit (SMD 0.02), explicitly judging the evidence inconclusive and advising against routine use. The frequently cited NSAID-comparable result rests mainly on the 2002 meta-analysis and small head-to-head trials versus nabumetone and celecoxib that lack a placebo arm, so apparent equivalence can simply reflect a shared placebo response rather than a true SAMe effect; several of these trials are old, heterogeneous in dose and formulation, and partly industry-funded (the celecoxib trial was supplied SAMe by NOW Foods). Examine grades Pain B but grades the Osteoarthritis Symptoms endpoint itself D (no effect), and ACR/AF and OARSI guidelines do not recommend SAMe at all. When the best placebo-controlled evidence is null and authoritative reviewers (NCCIH, Harvard Health) describe the benefit as small, inconsistent, or possibly due to chance, the honest grade is C: there is a plausible but unconfirmed signal, not a reliably demonstrated effect. I therefore grade this C rather than the B implied by the Examine Pain outcome.
評分透明度
所有分數由 7 層證據引擎計算，過程公開可查▸查看完整決策路徑（audit trail）
- compute_raw_score — 加權公式: L2×0.30 + L3×0.25 + L5×0.25 + L11×0.10 + L1×0.10 = 0.416
- tier_from_score — 依分數區間映射至 tier letter
- apply_hec_rules — 無高階證據可裁決
- tier_strict_requirement_check — Tier 條件達標，未降階
- detect_disputes — 偵測到 0 個 hard + 2 個 soft dispute
- decide_status — 依 tier + dispute 結果決定 status
台灣社群（PTT regimen/FITNESS/elderly/Pharmacy、Mobile01、Dcard、痞客邦）關於退化性關節炎的保健討論極為熱絡，但幾乎清一色集中在葡萄糖胺、軟骨素、UC-II（非變性第二型膠原）、MSM、膠原蛋白與綠唇貝；針對 S-腺苷甲硫胺酸（SAMe）用於骨關節炎的本土實測討論基本不存在，屬在地冷門補充品，無可萃取的鄉民共識。
- 陸上運動與肌力訓練
- 減重（過重者）
- 局部或口服 NSAID
查看 ClaimReview 結構化資料 (JSON-LD)
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