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Lemon Balm for Sleep Quality

AI preliminary evidence assessment

C

C 級｜AI 整體初步評級

This preliminary assessment is currently available in Traditional Chinese.

Exact question對成人，口服單一香蜂草（Melissa officinalis／lemon balm）相較安慰劑或其他條件相同的同期對照，是否改善睡眠品質或睡眠症狀，並有哪些不良反應？健康者、睡眠困擾、更年期與情緒困擾族群分層呈現。

已驗證評讀顯示研究結果方向不一致。主要限制包括：src-pmid-25680840-abstract：55人完成、71人招募，隨機總數未知；焦慮／失眠是GHQ-28次要複合終點，摘要未清楚報告獨立睡眠療效；src-pmid-29908682-abstract：80人隨機分組及PSQI正向結果保留；招募身分、資助與不良反應計數未知，暫不增加已確認獨立試驗數。

Additional assessment reasons await presentation; see the research results below.

Limitations affecting this assessment
  • 依提供的來源集獨立評讀；中性 PubMed 檢索完成70筆篩選、保留50筆未排除來源，不等於完整跨資料庫系統性回顧，亦未獨立驗證封存檔案。
  • 兩篇直接報告僅有摘要；三篇回顧僅有逐字全文摘錄與完整表格文字，雖已封存原始位元組，仍不代表取得完整文章。
  • 族群、製劑、劑量與結局異質，不能提出共同有效劑量、合併效果或唯一參與者總數。
  • 長期安全、救援藥物、因不良反應停藥及停用後症狀資料不足；未報告事件或未發現嚴重事件均不能解讀為零風險。
  • C為初步編輯分類，並非正式GRADE；confidence表示對本次評讀判斷的信心，並非療效機率。
  • 此背景讀者事實的必要欄位缺少足夠來源支持，因此未列為讀者研究結果，也未納入評級；同來源其他可驗證資訊仍分開保留。
  • 此背景讀者事實的必要欄位缺少足夠來源支持，因此未列為讀者研究結果，也未納入評級；同來源其他可驗證資訊仍分開保留。
  • 此背景讀者事實的必要欄位缺少足夠來源支持，因此未列為讀者研究結果，也未納入評級；同來源其他可驗證資訊仍分開保留。
  • 本次外部證據資料庫資料缺失，系統性回顧也未被納入該計分欄位；兩個欄位各依原規則採0.5中性政策值。這些值不是研究支持票，也不表示文獻中沒有系統性回顧。
  • src-pmid-25680840-abstract：55人完成、71人招募，隨機總數未知；焦慮／失眠是GHQ-28次要複合終點，摘要未清楚報告獨立睡眠療效。
  • src-pmid-29908682-abstract：80人隨機分組及PSQI正向結果保留；招募身分、資助與不良反應計數未知，暫不增加已確認獨立試驗數。
  • src-pmid-37131158-fulltext：60人隨機、44人完成；憂鬱與焦慮改善不能取代PSQI組間無顯著差異。
  • src-pmid-37927585-fulltext：104人隨機、100人分析；基線PSQI不平衡，全文胃部不適為補充組4例、安慰劑5例，優先於摘要概括措辭。
  • src-pmid-39683592-fulltext：30人交叉、每期2週；7日洗脫與統計章節第16–20日不一致。Garmin睡眠分期不是多項睡眠檢查；有製造商科學主管及兩位顧問利益關係。
  • src-pmid-33465795-fulltext：香蜂草與茴香混合製劑及MENQOL結果，不能作單一香蜂草獨立睡眠療效。
  • src-pmid-40054227-abstract：51項為全部非處方產品RCT，僅取得摘要，不能解讀為51項香蜂草試驗。
  • src-pmid-39458539-fulltext_excerpt：跨生命期心理健康敘述綜述，僅選定全文段落與完整表格可用。
  • src-pmid-41226605-fulltext_excerpt：敘述綜述明言異質性妨礙統合分析；選定全文與表格不能新增世代或取代原始分母。
  • src-pmid-41754356-fulltext_excerpt：整合綜述僅選定全文段落與完整表格可用；原始位元組已封存，不代表完整文章存取。
  • 保留5篇直接研究報告，來源支持至少4個不同試驗群體；心絞痛試驗的獨立性未明，正向睡眠結果仍保留。交叉期不重計；未證個別參與者完全無重疊，不合計為不重複總人數。保守計數沿現有計分用研究列投影，可能同時影響資助分母；不改權重。

Research results

Findings are currently provided in Traditional Chinese; source excerpts retain their original language.

Main result 1

14天

摘要報告焦慮患者數減少，未提供GHQ-28焦慮／失眠複合終點的清楚睡眠分項結果；無法確認獨立睡眠效益。

Applicability assessment: 研究對象為成人良性心悸患者；睡眠僅在次要精神症狀評估中提及，摘要未提供獨立睡眠結果。

Population
患有良性心悸的成人
Intervention
香蜂草葉水性凍乾萃取物
Comparator
安慰劑
Outcome
心悸與焦慮；失眠列於次要精神症狀評估，但固定結果未報告獨立睡眠分項
Follow-up
14天
Formulation
Not established
Dose
水性凍乾葉萃取物500 mg，每日兩次，共1000 mg/day

No additional short excerpt is shown for this finding. See the linked source to check the result.

View source

Main result 2

八週

PSQI總睡眠困擾相較安慰劑顯著降低（P<0.05）；摘要未提供效果量或信賴區間。

Applicability assessment: 研究對象為慢性穩定型心絞痛患者，睡眠困擾以PSQI評估；與一般睡眠困擾成人分開解讀。

Population
慢性穩定型心絞痛患者
Intervention
每日3克香蜂草補充品膠囊
Comparator
安慰劑
Outcome
憂鬱、焦慮、壓力及總睡眠困擾分數
Follow-up
八週
Formulation
Not established
Dose
香蜂草補充品3 g/day

No additional short excerpt is shown for this finding. See the linked source to check the result.

View source

Main result 3

12週

PSQI變化為香蜂草−0.69、安慰劑−0.19分，組間無顯著差異（p=0.15）；憂鬱及焦慮改善不代表睡眠改善。

Applicability assessment: 研究對象為第二型糖尿病合併憂鬱症狀患者，與其他成人睡眠族群分開解讀。

Population
有憂鬱症狀的第二型糖尿病患者
Intervention
香蜂草水醇萃取物
Comparator
烘焙麵粉安慰劑
Outcome
睡眠品質
Follow-up
12週
Formulation
Not established
Dose
水醇萃取物350 mg，每日兩次，午餐及晚餐後服用，共700 mg/day
Source excerpt: We failed to find any significant effect of supplementation on hs-CRP, sleep quality, and blood pressure (Table 4).
View source

Main result 4

三週

PSQI由10.9降至3.5，安慰劑由8.6降至6.6；組別×時間交互作用p<0.001，但基線PSQI已不平衡（p=0.006）。

Applicability assessment: 研究納入有情緒困擾或睡眠不佳的健康成人；製劑採磷脂載體，基線睡眠品質不平衡。

Population
有情緒困擾或睡眠不佳的健康成人
Intervention
Relissa磷脂載體香蜂草葉水性萃取物
Comparator
安慰劑
Outcome
睡眠品質評分
Follow-up
三週
Formulation
Not established
Dose
Relissa磷脂載體水萃取製劑200 mg，每日兩次，共400 mg/day；標準化17%–23%羥基肉桂酸衍生物

No additional short excerpt is shown for this finding. See the linked source to check the result.

View source

Main result 5

每期兩週

ISI較安慰劑低2.9分（6.8對9.7；p=0.003）。穿戴裝置估計深睡增加、REM減少；總睡眠、淺睡與清醒時間無顯著改變，REM減少本身的臨床益處未確立。

Applicability assessment: 研究納入起床疲倦或睡後未恢復精神的成人，使用香蜂草磷脂製劑並採交叉設計。

Population
起床疲倦或睡後未恢復精神的18至65歲成人
Intervention
香蜂草Phytosome磷脂製劑
Comparator
相同外觀的安慰劑
Outcome
失眠嚴重程度指數評分
Follow-up
每期兩週
Formulation
Not established
Dose
每錠200 mg香蜂草Phytosome製劑，每晚睡前30分鐘兩錠，共400 mg/day

No additional short excerpt is shown for this finding. See the linked source to check the result.

View source

Additional finding 6

複方組相較安慰劑組的睡眠困擾程度較低。

Applicability assessment: 研究更年期婦女的睡眠困擾，但介入為纈草與香蜂草複方。

Population
50至60歲、主訴睡眠困擾的婦女
Intervention
纈草與香蜂草複方
Comparator
安慰劑
Outcome
睡眠困擾及匹茲堡睡眠品質指數
Follow-up
Not established
Formulation
Not established
Dose
Not established
Source excerpt: A significant difference was observed with reduced levels of sleep disorders amongst the experimental group when compared to the placebo group.
View source

Safety finding 7

14天

摘要未見嚴重副作用跡象；未提供所有不良反應的分類或計數。

Applicability assessment: 安全性描述來自成人良性心悸試驗；摘要僅提及嚴重副作用。

Population
患有良性心悸的成人
Intervention
香蜂草葉水性凍乾萃取物
Comparator
安慰劑
Outcome
嚴重副作用
Follow-up
14天
Formulation
Not established
Dose
水性凍乾葉萃取物500 mg，每日兩次，共1000 mg/day
Source excerpt: Also, M. officinalis extract showed no indication of any serious side effects.
View source

Additional finding 8

四週

複方組相較安慰劑組的失眠嚴重程度及總PSQI分數下降較多。

Applicability assessment: 失眠患者試驗使用香蜂草與荊芥屬植物複方。

Population
符合納入條件的失眠患者
Intervention
香蜂草乾粉與Nepeta menthoides水性凍乾萃取物複方
Comparator
安慰劑
Outcome
失眠嚴重程度、PSQI及睡眠日誌
Follow-up
四週
Formulation
Not established
Dose
Not established

No additional short excerpt is shown for this finding. See the linked source to check the result.

View source

Additional finding 9

四週

複方組四週後的失眠嚴重程度、焦慮及憂鬱評分相較安慰劑組改善。

Applicability assessment: 失眠患者試驗使用香蜂草與Nepeta menthoides複方。

Population
診斷為失眠的參與者
Intervention
香蜂草與Nepeta menthoides複方
Comparator
安慰劑
Outcome
失眠嚴重程度、焦慮及憂鬱
Follow-up
四週
Formulation
Not established
Dose
Not established

No additional short excerpt is shown for this finding. See the linked source to check the result.

View source

Safety finding 10

12週

患者未報告副作用；小樣本及失訪限制安全性判斷。

Applicability assessment: 副作用報告來自第二型糖尿病合併憂鬱症狀患者的短期試驗。

Population
有憂鬱症狀的第二型糖尿病患者
Intervention
香蜂草水醇萃取物
Comparator
烘焙麵粉安慰劑
Outcome
患者報告的副作用
Follow-up
12週
Formulation
Not established
Dose
水醇萃取物350 mg，每日兩次，午餐及晚餐後服用，共700 mg/day

No additional short excerpt is shown for this finding. See the linked source to check the result.

View source

Safety finding 11

三週

輕微胃部不適補充組4例、安慰劑5例；未報告其他特定治療期間事件或嚴重不良事件。採全文計數，不採摘要概括無事件措辭。

Applicability assessment: 安全性資料來自有情緒困擾或睡眠不佳的健康成人，所用製劑為磷脂載體香蜂草萃取物。

Population
有情緒困擾或睡眠不佳的健康成人
Intervention
Relissa磷脂載體香蜂草葉水性萃取物
Comparator
安慰劑
Outcome
輕微胃部不適、其他治療期間事件及嚴重不良事件
Follow-up
三週
Formulation
Not established
Dose
Relissa磷脂載體水萃取製劑200 mg，每日兩次，共400 mg/day；標準化17%–23%羥基肉桂酸衍生物

No additional short excerpt is shown for this finding. See the linked source to check the result.

View source

Additional finding 12

六週

複方相較安慰劑，客觀及主觀睡眠指標未見更佳改善。

Applicability assessment: 睡眠受損成人的安慰劑對照試驗使用含香蜂草與其他成分的複方。

Population
睡眠受損的成人
Intervention
含L-茶胺酸、香蜂草、纈草及番紅花萃取物的複方
Comparator
安慰劑
Outcome
客觀及主觀睡眠指標
Follow-up
六週
Formulation
Not established
Dose
Not established
Source excerpt: Among adults with impaired sleep, a nutraceutical combination did not improve objective or subjective sleep parameters more than a placebo infusion.
View source

Safety finding 13

每期兩週

研究期間未偵測到與製劑相關副作用；30人短期暴露不足以確立長期或罕見事件安全性。

Applicability assessment: 副作用資料來自起床疲倦或睡後未恢復精神成人的短期交叉試驗。

Population
起床疲倦或睡後未恢復精神的18至65歲成人
Intervention
香蜂草Phytosome磷脂製劑
Comparator
相同外觀的安慰劑
Outcome
與製劑相關的副作用
Follow-up
每期兩週
Formulation
Not established
Dose
每錠200 mg香蜂草Phytosome製劑，每晚睡前30分鐘兩錠，共400 mg/day
Source excerpt: No side effects related to MOP supplementation were detected during the study.
View source

Additional finding 14

綜述認為成人失眠非處方產品的整體發現仍未定論。

Applicability assessment: 這是成人失眠非處方產品研究的範疇綜述，並非獨立的單一香蜂草試驗。

Population
有失眠症狀的成人
Intervention
非處方產品；文中提及香蜂草與茴香複方
Comparator
綜述納入試驗主要以安慰劑作比較
Outcome
成人失眠症狀及安全性
Follow-up
Not established
Formulation
Not established
Dose
Not established
Source excerpt: Over-the-counter products show promising, but inconclusive findings in alleviating insomnia symptoms in adults.
View source

Additional finding 15

三週

研究報告PSQI分數隨時間改善，較高劑量組的變化較大且較早出現。

Applicability assessment: 研究有情緒困擾或睡眠不佳的成人，但採開放標籤劑量比較，沒有安慰劑組。

Population
睡眠品質不佳或有臨床顯著情緒困擾的成人
Intervention
每日200或400毫克香蜂草磷脂製劑
Comparator
另一劑量的香蜂草磷脂製劑
Outcome
PSQI睡眠品質
Follow-up
三週
Formulation
Not established
Dose
Not established
Source excerpt: PSQI scores significantly improved over time (P < 0.0001), with greater and earlier benefits at 400 mg/day (-30% vs. -15%; P < 0.05).
View source

Sources consulted

  1. Valerian/lemon balm use for sleep disorders during menopause. Context source; not counted as an included human-result report Abstract only · 2026-10-06T04:26:12.128722Z
  2. Heart palpitation relief with Melissa officinalis leaf extract: double blind, randomized, placebo controlled trial of efficacy and safety. Abstract only · 2026-10-06T04:26:12.128722Z
  3. Efficacy of a Combination of Melissa officinalis L. and Nepeta Menthoides Boiss. & Buhse on Insomnia: A Triple-Blind, Randomized Placebo-Controlled Clinical Trial. Context source; not counted as an included human-result report Abstract only · 2026-10-06T04:26:12.128722Z
  4. The effects of Melissa officinalis supplementation on depression, anxiety, stress, and sleep disorder in patients with chronic stable angina. Abstract only · 2026-10-06T04:26:12.128722Z
  5. Effects of Herbal combination (Melissa officinalis L. and Nepeta menthoides Boiss. & Buhse) on insomnia severity, anxiety and depression in insomniacs: Randomized placebo controlled trial. Context source; not counted as an included human-result report Abstract only · 2026-10-06T04:26:12.128722Z
  6. The effects of melissa officinalis on depression and anxiety in type 2 diabetes patients with depression: a randomized double-blinded placebo-controlled clinical trial. Full text · 2026-10-06T04:26:12.128722Z
  7. The possible "calming effect" of subchronic supplementation of a standardised phospholipid carrier-based Melissa officinalis L. extract in healthy adults with emotional distress and poor sleep conditions: results from a prospective, randomised, double-blinded, placebo-controlled clinical trial. Full text · 2026-10-06T04:26:12.128722Z
  8. Effect of a nutraceutical combination on sleep quality among people with impaired sleep: a randomised, placebo-controlled trial. Context source; not counted as an included human-result report Abstract only · 2026-10-06T04:26:12.128722Z
  9. Effects of Melissa officinalis Phytosome on Sleep Quality: Results of a Prospective, Double-Blind, Placebo-Controlled, and Cross-Over Study. Full text · 2026-10-06T04:26:12.128722Z
  10. Over-the-counter products for insomnia in adults: A scoping review of randomised controlled trials. Context source; not counted as an included human-result report Abstract only · 2026-10-06T04:26:12.128722Z
  11. Melissa phospholipids improves sleep quality and mental well-being: concluding results from clinical study in adults with emotional distress. Context source; not counted as an included human-result report Abstract only · 2026-10-06T04:26:12.128722Z

Reading and assessment notes

This is an AI preliminary assessment, not expert review or formal GRADE. Read the method and common limitations.

Absence of reported harms does not establish safety. This summary does not provide individual treatment or dosing advice.

Data and assessment record

Search coverage for this case

對成人，口服單一香蜂草（Melissa officinalis／lemon balm）相較安慰劑或其他條件相同的同期對照，是否改善睡眠品質或睡眠症狀，並有哪些不良反應？健康者、睡眠困擾、更年期與情緒困擾族群分層呈現。

Searched：2026-10-06T04:26:12.128722Z · Databases：PubMed

70 records identified; 70 screened; 5 reports included, representing at least 4 study populations. Some relationships remain unresolved.

Some included reports were assessed without full text.

  • 部分候選文獻未取得全文，完整偏倚風險與次要結果評讀受限。
  • 系統檢索限於 PubMed；未涵蓋所有資料庫與完整引文追查。

Processing record

Evidence summary available

Sources through：2026-10-06 · Generated：2026-10-06T04:52:24.959414+00:00

Retrieved 70 records · Screened 70 · Included 5 reports · Omitted 65

Run：rating-candidate-final-v2

codex_cli / gpt-6.1-sol / problem-search-source-bound-l2+l11-v1

{
  "included": 5,
  "limits_hit": [
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    "limited_citation_tracing"
  ],
  "omitted": 65,
  "retrieved": 70,
  "screened": 70
}

sha256:61d4657f39a8af13809423687185df9ae0f37f008f0fa14834366ed4d0e931fe