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Apigenin for Sleep Quality

Verdict: Insufficient Evidence

Across 4 PubMed studies, the evidence for Apigenin in Sleep Quality grades Tier U — unverified / insufficient. Research is still too limited to draw a firm conclusion.

U ⚫ U Unverified Insufficient Evidence

🔬Why this grade7-layer evidence engine

⚖️

Scoring transparency

All scores computed by a 7-layer evidence engine — fully auditable
Raw score 0.54
D
C
B
A
S
← counter-evidence / ineffectiveeffective / strong evidence →
Final grade
U · Insufficient Evidence
Confidence
72%
Broadly consistent
Evidence level
E3
Single high-quality meta-analysis

How strongly each layer supports this effect

lower = less supportive
L11 AI re-checkIndependent read
0.20
L1 ExamineGlobal benchmark
0.50
L5 Clinical bodiesAuthoritative stance
0.50
L2 PubMedPrimary literature
0.60
L3 MechanismPlausibility
0.65
Against Mixed Supports
▸View the full decision path (audit trail)
  1. compute_raw_score — 加權公式: L2×0.30 + L3×0.25 + L5×0.25 + L11×0.10 + L1×0.10 = 0.538
  2. tier_from_score — 依分數區間映射至 tier letter
  3. apply_hec_rules — 無高階證據可裁決
  4. tier_strict_requirement_check — Tier 條件達標，未降階
  5. detect_disputes — 偵測到 0 個 hard + 0 個 soft dispute
  6. decide_status — 依 tier + dispute 結果決定 status

📄PubMed studies (4)L2 · primary research & systematic reviews

Effects of chamomile (Matricaria chamomilla L.) on sleep: A systematic review and meta-analysis of clinical trials
PMID: 39106912 2024 統合分析 n = 772
Finding: Significant reduction in PSQI score across 5 studies (WMD -1.88); no improvement in sleep duration, efficiency, or daytime functioning.
Effect size: [object Object]
View on PubMed
Investigation effect of oral chamomilla on sleep quality in elderly people in Isfahan: A randomized control trial
PMID: 28616420 2017 隨機對照試驗 n = 77
Finding: Significant improvement in sleep quality vs control post-intervention (P<0.001).
🟠 Limited quality
View on PubMed
Effects of an intervention with drinking chamomile tea on sleep quality and depression in sleep disturbed postnatal women: a randomized controlled trial
PMID: 26483209 2016 隨機對照試驗 n = 80
Finding: Lower physical-symptoms sleep inefficiency vs control at 2 wks (t=-2.482, P=0.015); benefit not sustained at 4-wk follow-up.
🟠 Limited quality Effect size: [object Object]
View on PubMed
Preliminary examination of the efficacy and safety of a standardized chamomile extract for chronic primary insomnia: a randomized placebo-controlled pilot study
PMID: 21939549 2011 RCT (double-blind) n = 34
Finding: No significant between-group differences on sleep diary measures; modest non-significant gains in daytime functioning.
Government Effect size: [object Object]
View on PubMed

🏛️Regulatory & authoritative positionsL4/L5 · FDA / EMA / NIH ODS / Cochrane / Mayo …

L4a US FDA
Not addressed
L4d TW TFDA / 衛福部
Cautious
食品、食品添加物……其標示、宣傳或廣告，不得有不實、誇張或易生誤解之情形；……不得為醫療效能之標示、宣傳或廣告。 source↗
L5a NIH Office of Dietary Supplements
Cautious
There isn't enough evidence to determine whether chamomile is helpful for any health condition. Limited evidence from small studies suggests that chamomile might be helpful for generalized anxiety disorder and sleep, but more research is needed. source↗
✓PMID 100% verifiedevery citation checked via NCBI Entrez
🔬4 PubMed studiesindependently re-checked by multiple sub-agents
engine_version: v1.0 claim_id: CLM-COND-sleep-quality-INT-apigenin-001 繁體中文版 →