Legacy AI grade · Sources dated 2026-06-01. Not expert reviewed. Coverage is limited to the listed sources. About the new summary workflow
Apigenin for Insomnia
There is not enough evidence to say whether isolated apigenin helps with insomnia. No human trial has tested the purified compound for sleep; the few existing studies used whole chamomile extract, which is not the same thing.
Why this grade7-layer evidence engine
This claim is graded Unverified (Insufficient Evidence) because there are zero human randomized trials of isolated apigenin for insomnia. Every clinical signal comes from whole-herb chamomile extract, in which apigenin is only about 1.2% alongside many other flavonoids and terpenes, so those results cannot be validly attributed to the purified compound.
The two proxy trials are also weak and inconsistent. Zick 2011 (PMID 21939549), a double-blind pilot in 34 adults with chronic primary insomnia, found only small, non-significant improvements in sleep latency and total sleep time versus placebo. Adib-Hajbaghery 2017 (PMID 29154054), in 60 nursing-home elders, reported better sleep-quality scores, but it was single-blind with a no-treatment comparator, carrying a high risk of bias.
Health authorities offer no support. NIH/NCCIH states there isn't enough evidence that chamomile helps any condition, and Cleveland Clinic notes the sleep research is limited; the FDA, EFSA, NHS and WHO do not address isolated apigenin at all. A sleep-medicine guideline (AASM) even advises against herbal/OTC sleep aids as a class. A possible drug-interaction concern (CYP enzyme inhibition) adds further caution.
Scoring transparency
All scores computed by a 7-layer evidence engine — fully auditable▸View the full decision path (audit trail)
- compute_raw_score — 加權公式: L2×0.30 + L3×0.25 + L5×0.25 + L11×0.10 + L1×0.10 = 0.384
- tier_from_score — 依分數區間映射至 tier letter
- apply_hec_rules — 無高階證據可裁決
- tier_strict_requirement_check — D 級條件未達 (需 E1-E3 negative；實際 E6)
- detect_disputes — 偵測到 0 個 hard + 0 個 soft dispute
- decide_status — 依 tier + dispute 結果決定 status