Vitamin D for Hypertension
Verdict: Counter-Evidence
Across 5 PubMed studies, the evidence for Vitamin D in Hypertension grades Tier D — counter-evidence. High-quality evidence indicates it is not effective (or is harmful) for this use.
D 🔴 D Counter-Evidence Counter-Evidence
Why this grade7-layer evidence engine
⚖️
Scoring transparency
All scores computed by a 7-layer evidence engine — fully auditableRaw score 0.25
D
C
B
A
S
← counter-evidence / ineffectiveeffective / strong evidence →
Final grade
D · Counter-Evidence
Confidence
85%
Highly consistent evidence
Evidence level
E2
Multiple high-quality MAs (≥2 independent, consistent)
▸View the full decision path (audit trail)
- compute_raw_score — 加權公式: L2×0.30 + L3×0.25 + L5×0.25 + L11×0.10 + L1×0.10 = 0.248
- tier_from_score — 依分數區間映射至 tier letter
- apply_hec_rules — 高品質 SR/MA 顯示 negative 主導 (4 negative > 1 positive)，下層 RCT 不能推翻
- apply_hec_override — HEC-1 高階證據 negative — 強制由 U 改為 D
- tier_strict_requirement_check — Tier 條件達標，未降階
- detect_disputes — 偵測到 0 個 hard + 1 個 soft dispute
- decide_status — 依 tier + dispute 結果決定 status
PubMed studies (5)L2 · primary research & systematic reviews
Effect of Vitamin D Supplementation on Blood Pressure: A Systematic Review and Meta-analysis Incorporating Individual Patient Data
Finding: No effect of vitamin D supplementation on SBP (0.0 mmHg, 95% CI -0.8 to 0.8, P=.97) or DBP (-0.1 mmHg, 95% CI -0.6 to 0.5, P=.84).
View on PubMed Effect of Vitamin D on Blood Pressure and Hypertension in the General Population: An Update Meta-Analysis of Cohort Studies and Randomized Controlled Trials
Finding: No significant effect on SBP (WMD -0.00 mmHg, 95% CI -0.71 to 0.71) or DBP (WMD 0.19 mmHg, 95% CI -0.29 to 0.67) in the general population.
View on PubMed Effects of vitamin D supplementation on markers for cardiovascular disease and type 2 diabetes: an individual participant data meta-analysis of randomized controlled trials
Finding: No effect of vitamin D supplementation on blood pressure as a main outcome across pooled individual participant data.
View on PubMed Effect of Vitamin D supplementation on blood pressure in hypertensive individuals with hypovitaminosis D: a systematic review and meta-analysis
Finding: SBP significantly reduced by vitamin D supplementation, but DBP unaffected, in hypertensive patients with hypovitaminosis D.
View on PubMed Effect of vitamin D supplementation on blood pressure parameters in patients with vitamin D deficiency: a systematic review and meta-analysis
Finding: Small but significant fall in DBP (-1.65 mmHg, 95% CI -3.05 to -0.25) with no significant effect on SBP or other BP parameters, in vitamin D-deficient patients.
View on PubMed Regulatory & authoritative positionsL4/L5 · FDA / EMA / NIH ODS / Cochrane / Mayo …
L4a US FDA
Supportive
Vitamin D-3 is recognized as GRAS source↗
L4b EU EFSA
Supportive
cause and effect relationship has been established source↗
L4c UK NHS
Supportive
everyone should consider taking a daily vitamin D supplement during the autumn and winter source↗
L4d TW TFDA / 衛福部
Supportive
每日維生素D攝取量需達10微克 source↗
L4e WHO
Cautious
not recommended for all pregnant women source↗
L5a NIH Office of Dietary Supplements
Supportive
Vitamin D is a fat-soluble vitamin source↗
L5b Mayo Clinic
Cautious
researchers are also studying whether vitamin D can reduce blood pressure, but evidence is conflicting source↗
L5c Cleveland Clinic
Against
There are many other claims about the benefits of vitamin D for heart health, but they aren't substantiated by high-quality scientific studies. source↗
L5d Harvard Health
Against
high monthly doses of supplemental vitamin D did little to ward off cardiovascular disease source↗