Schisandra for Cognitive Function

Verdict: Taiwan Regulatory Restriction

Across 2 PubMed studies, the evidence for Schisandra in Cognitive Function grades Tier U — unverified / insufficient.

U ⚫ U Unverified Taiwan Regulatory Restriction

🔬Why this grade7-layer evidence engine

⚖️

Scoring transparency

All scores computed by a 7-layer evidence engine — fully auditable
Raw score 0.45
D
C
B
A
S
← counter-evidence / ineffectiveeffective / strong evidence →
Final grade
U · Taiwan Regulatory Restriction
Confidence
47%
Conflicting evidence
Evidence level
E10
Mechanism / case reports / no human evidence

How strongly each layer supports this effect

lower = less supportive
L11 AI re-checkIndependent read
0.20
L2 PubMedPrimary literature
0.40
L1 ExamineGlobal benchmark
0.50
L3 MechanismPlausibility
0.50
L5 Clinical bodiesAuthoritative stance
0.55
Against Mixed Supports
View the full decision path (audit trail)
  1. compute_raw_score — 加權公式: L2×0.30 + L3×0.25 + L5×0.25 + L11×0.10 + L1×0.10 = 0.453
  2. tier_from_score — 依分數區間映射至 tier letter
  3. apply_hec_rules — 僅有 E10 級證據 (cohort/animal/mechanism),不足以下結論
  4. tier_strict_requirement_check — C 級條件未達 (需 E1-E8;實際 E10 僅機轉)
  5. detect_disputes — 偵測到 0 個 hard + 0 個 soft dispute
  6. decide_status — 依 tier + dispute 結果決定 status

📄PubMed studies (2)L2 · primary research & systematic reviews

An overview of neuroprotective and cognitive enhancement properties of lignans from Schisandra chinensis
PMID: 29136774 2018 Other
Finding: Review concludes crude extracts and isolated lignans protect against neuronal cell damage and enhance cognitive performance in preclinical models; no human RCT data presented.
🟠 Limited quality
View on PubMed
Schizandrin, an antioxidant lignan from Schisandra chinensis, ameliorates Abeta1-42-induced memory impairment in mice
PMID: 22829961 2012 Animal Study
Finding: Schizandrin significantly improved Abeta1-42-induced memory deficits and raised brain antioxidant enzyme activity in mice; positioned as a potential cognitive enhancer via antioxidative action.
🟠 Limited quality
View on PubMed

🏛️Regulatory & authoritative positionsL4/L5 · FDA / EMA / NIH ODS / Cochrane / Mayo …

L4a US FDA
Neutral
SCHISANDRA CHINENSIS FRUIT source↗
L4e WHO
Neutral
Fructus Schisandrae source↗
PMID 100% verifiedevery citation checked via NCBI Entrez
🔬2 PubMed studiesindependently re-checked by multiple sub-agents
engine_version: v1.0 claim_id: CLM-COND-cognitive-function-INT-schisandra-001 繁體中文版 →