Legacy AI grade · Sources dated 2026-06-09. Not expert reviewed. Coverage is limited to the listed sources. About the new summary workflow

Schisandra for Cognitive Function

Verdict: Taiwan Regulatory Restriction

Across 2 PubMed studies, the evidence for Schisandra in Cognitive Function grades Tier U — unverified / insufficient.

U ⚫ U Unverified Taiwan Regulatory Restriction

🔬Why this grade7-layer evidence engine

⚖️

Scoring transparency

All scores computed by a 7-layer evidence engine — fully auditable
Raw score 0.45
D
C
B
A
S
← counter-evidence / ineffectiveeffective / strong evidence →
Final grade
U · Taiwan Regulatory Restriction
Confidence
47%
Conflicting evidence
Evidence level
E10
Mechanism / case reports / no human evidence

How strongly each layer supports this effect

lower = less supportive
L11 AI re-checkIndependent read
0.20
L2 PubMedPrimary literature
0.40
L1 ExamineGlobal benchmark
0.50
L3 MechanismPlausibility
0.50
L5 Clinical bodiesAuthoritative stance
0.55
Against Mixed Supports
▸View the full decision path (audit trail)
  1. compute_raw_score — 加權公式: L2×0.30 + L3×0.25 + L5×0.25 + L11×0.10 + L1×0.10 = 0.453
  2. tier_from_score — 依分數區間映射至 tier letter
  3. apply_hec_rules — 僅有 E10 級證據 (cohort/animal/mechanism),不足以下結論
  4. tier_strict_requirement_check — C 級條件未達 (需 E1-E8;實際 E10 僅機轉)
  5. detect_disputes — 偵測到 0 個 hard + 0 個 soft dispute
  6. decide_status — 依 tier + dispute 結果決定 status

📄PubMed studies (2)L2 · primary research & systematic reviews

An overview of neuroprotective and cognitive enhancement properties of lignans from Schisandra chinensis
PMID: 29136774 2018 Other
Finding: Review concludes crude extracts and isolated lignans protect against neuronal cell damage and enhance cognitive performance in preclinical models; no human RCT data presented.
🟠 Limited quality
View on PubMed
Schizandrin, an antioxidant lignan from Schisandra chinensis, ameliorates Abeta1-42-induced memory impairment in mice
PMID: 22829961 2012 Animal Study
Finding: Schizandrin significantly improved Abeta1-42-induced memory deficits and raised brain antioxidant enzyme activity in mice; positioned as a potential cognitive enhancer via antioxidative action.
🟠 Limited quality
View on PubMed

🏛️Regulatory & authoritative positionsL4/L5 · FDA / EMA / NIH ODS / Cochrane / Mayo …

L4a US FDA
Neutral
SCHISANDRA CHINENSIS FRUIT source↗
L4e WHO
Neutral
Fructus Schisandrae source↗
✓PMID 100% verifiedevery citation checked via NCBI Entrez
🔬2 PubMed studiesindependently re-checked by multiple sub-agents
engine_version: v1.0 claim_id: CLM-COND-cognitive-function-INT-schisandra-001 繁體中文版 →