Chlorella for Cholesterol
Verdict: Published with Warning
Across 4 PubMed studies, the evidence for Chlorella in Cholesterol grades Tier C — weak evidence. Effective, but with safety or population caveats.
C 🟠 C Weak Evidence Published with Warning
Why this grade7-layer evidence engine
⚖️
Scoring transparency
All scores computed by a 7-layer evidence engine — fully auditableRaw score 0.61
D
C
B
A
S
← counter-evidence / ineffectiveeffective / strong evidence →
Final grade
C · Published with Warning
Confidence
77%
Broadly consistent
Evidence level
E2
Multiple high-quality MAs (≥2 independent, consistent)
▸View the full decision path (audit trail)
- compute_raw_score — 加權公式: L2×0.30 + L3×0.25 + L5×0.25 + L11×0.10 + L1×0.10 = 0.613
- tier_from_score — 依分數區間映射至 tier letter
- apply_hec_rules — 高品質 SR/MA 顯示 positive (2 篇 > 0 negative)
- tier_strict_requirement_check — Tier 條件達標，未降階
- detect_disputes — 偵測到 0 個 hard + 0 個 soft dispute
- decide_status — 依 tier + dispute 結果決定 status
PubMed studies (4)L2 · primary research & systematic reviews
Effect of Chlorella supplementation on cardiovascular risk factors: A meta-analysis of randomized controlled trials
Finding: Across 19 RCTs Chlorella significantly reduced total cholesterol (WMD -9.09 mg/dl, 95% CI -12.91 to -5.26, p<0.001) and LDL-C (WMD -8.32 mg/dl, 95% CI -12.22 to -4.42, p<0.001); HDL-C (+1.54 mg/dl, p=0.443) and triglycerides (+1.73 mg/dl, p=0.706) were not significantly changed.
View on PubMed Effect of supplementation with Chlorella vulgaris on lipid profile in adults: A systematic review and dose-response meta-analysis of randomized controlled trials
Finding: Across 10 RCTs (264 intervention, 275 control) Chlorella vulgaris significantly reduced total cholesterol (MD -7.47 mg/dl, 95% CI -12.98 to -1.96) and LDL-C (MD -7.71 mg/dl, 95% CI -14.05 to -1.37); triglycerides (MD -2.11 mg/dl, 95% CI -7.28 to 3.06) and HDL-C (MD -0.45 mg/dl, 95% CI -0.67 to 1.57) were not significantly affected.
View on PubMed Chlorella supplementation diminishes cardiovascular risk factors in adults: A GRADE-assessed systematic review and meta-analyses of randomized clinical trials
— See PubMed for details
View on PubMed Impact of daily Chlorella consumption on serum lipid and carotenoid profiles in mildly hypercholesterolemic adults: a double-blinded, randomized, placebo-controlled study
Finding: In mildly hypercholesterolemic adults Chlorella reduced total cholesterol (-1.6% vs +0.03% placebo, p=0.036), triglycerides (-10.3% vs +11.9%, p=0.002), VLDL cholesterol (-11% vs +11.8%, p=0.006) and apolipoprotein B (-1.5% vs +1.7%, p=0.044) over 4 weeks.
View on PubMed Regulatory & authoritative positionsL4/L5 · FDA / EMA / NIH ODS / Cochrane / Mayo …
L4a US FDA
Cautious
Consumers who use OTC chelation products for detoxification are exposed to all the risks associated with chelation. These risks are not acceptable, given that there is no proof that 'detoxification' using these products is effective to prevent or treat any condition or disease. source↗
L4b EU EFSA
Against
L4d TW TFDA / 衛福部
Neutral
綠藻（小球藻）產品應符合衛福部「可供食用藻類衛生標準」，並就重金屬（砷、鉛、鎘、汞）、微囊藻毒素、神經毒素（BMAA）、農藥、塑化劑及微生物等項目進行檢驗。 source↗
L5a NIH Office of Dietary Supplements
Cautious
L5e Specialty Society (condition-mapped)
Not addressed