Resveratrol for Type 2 Diabetes
The evidence that resveratrol controls type 2 diabetes is weak and genuinely conflicting: the most rigorous reviews and the largest trial found no benefit, while smaller meta-analyses report only modest effects that depend on doses far above what regulators allow. It should not replace proven diabetes care.
Why this grade7-layer evidence engine
This earns a weak, disputed grade because the strongest evidence points against a real benefit. A Cochrane review (PMID 31978258) found no effect on HbA1c, fasting glucose or HOMA-IR; an umbrella review of meta-analyses (PMID 34320173) concluded the data do not support resveratrol for cardiometabolic management in type 2 diabetes; and the largest, longest trial (PMID 27520400, 192 patients over six months) showed nothing at either 40 or 500 mg per day.
Several moderate-quality meta-analyses do report reductions in HbA1c, HOMA-IR and fasting glucose (PMID 33480264, PMID 34484395, PMID 35685602). But these effects are small, inconsistent across studies, and largely confined to short trials using high doses of 1000 mg per day or more. That level sits far above the 150 mg per day ceiling set by EU and Taiwan regulators, so any benefit is hard to obtain legally or in practice.
Authorities reinforce the caution. The US FDA has authorized no health claim and ceased evaluating resveratrol at the notifier's request, EFSA permits it only as a capped novel food with no approved claims, Harvard Health reports no proven human benefit, and the American Diabetes Association recommends against supplements of this kind. There is also a real interaction risk in diabetics, including with warfarin and oral hypoglycemics, so diet, weight loss, exercise and standard medication remain the established options.
Scoring transparency
All scores computed by a 7-layer evidence engine — fully auditable▸View the full decision path (audit trail)
- compute_raw_score — 加權公式: L2×0.30 + L3×0.25 + L5×0.25 + L11×0.10 + L1×0.10 = 0.41
- tier_from_score — 依分數區間映射至 tier letter
- apply_hec_rules — 高品質 SR/MA 顯示 positive (2 篇 > 0 negative)
- tier_strict_requirement_check — Tier 條件達標，未降階
- detect_disputes — 偵測到 1 個 hard + 0 個 soft dispute
- decide_status — 依 tier + dispute 結果決定 status