Aloe Vera for Skin Health
Verdict: Published with Warning
Across 3 PubMed studies, the evidence for Aloe Vera in Skin Health grades Tier C — weak evidence. Effective, but with safety or population caveats.
C 🟠 C Weak Evidence Published with Warning
Why this grade7-layer evidence engine
⚖️
Scoring transparency
All scores computed by a 7-layer evidence engine — fully auditableRaw score 0.47
D
C
B
A
S
← counter-evidence / ineffectiveeffective / strong evidence →
Final grade
C · Published with Warning
Confidence
75%
Broadly consistent
Evidence level
E3
Single high-quality meta-analysis
▸View the full decision path (audit trail)
- compute_raw_score — 加權公式: L2×0.30 + L3×0.25 + L5×0.25 + L11×0.10 + L1×0.10 = 0.473
- tier_from_score — 依分數區間映射至 tier letter
- apply_hec_rules — 高品質 SR/MA 顯示 positive (1 篇 > 0 negative)
- tier_strict_requirement_check — | C→D 因 scope.conflation_risk=true 且 L11 獨評較低 (B7-2 tier cap)
- detect_disputes — 偵測到 0 個 hard + 0 個 soft dispute
- decide_status — 依 tier + dispute 結果決定 status
PubMed studies (3)L2 · primary research & systematic reviews
Dietary Aloe Vera Supplementation Improves Facial Wrinkles and Elasticity and It Increases the Type I Procollagen Gene Expression in Human Skin in vivo
Finding: Facial wrinkles improved significantly (p<0.05) in both dose groups; elasticity improved in the low-dose group; Type I procollagen mRNA rose (low-dose 4.74-fold, high-dose 1.75-fold) and high-dose reduced MMP-1 (0.51-fold).
View on PubMed Effects of low-dose Aloe sterol supplementation on skin moisture, collagen score and objective or subjective symptoms: 12-week, double-blind, randomized controlled trial
Finding: TEWL significantly reduced vs placebo at week 12 (difference -0.641, p=0.0090) and collagen score increased more in the aloe group (p=0.0291); effect magnitudes were small and skin hydration difference was modest.
View on PubMed Effects of Aloe vera on Burn Injuries: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Finding: Topical aloe vera significantly reduced mean wound-healing time vs other topicals (MD -3.76 days, 95% CI -5.69 to -1.84) for second-degree burns without increased infection risk; analgesic benefit uncertain.
View on PubMed Regulatory & authoritative positionsL4/L5 · FDA / EMA / NIH ODS / Cochrane / Mayo …
L4a US FDA
Against
The stimulant laxative ingredients aloe (including aloe extract and aloe flower extract) and cascara sagrada (including casanthranol, cascara fluidextract aromatic, cascara sagrada bark, cascara sagrada extract, and cascara sagrada fluidextract) in OTC drug products are not generally recognized as safe and effective or are misbranded. source↗
L4b EU EFSA
Against
L4d TW TFDA / 衛福部
Cautious
費拉蘆薈(Aloe vera)及好望角蘆薈(A. ferox)品種的葉子，須確實完全去皮後，才能加工使用，且蘆薈素(aloin)的含量不可以超過10 ppm。使用蘆薈葉作為原料之食品必須標示「孕婦忌食」警語字樣；產品檢具經檢驗機構檢驗所含「蘆薈素」含量低於1 ppm之分析證明者，得免標前述之警語。 source↗
L4e WHO
Cautious
Aloe whole leaf extract is possibly carcinogenic to humans (Group 2B). [IARC Monographs Vol. 108, 2016 — sufficient evidence of carcinogenicity in experimental animals, inadequate evidence in humans] source↗
L5a NIH Office of Dietary Supplements
Cautious
L5b Mayo Clinic
Cautious
People mainly put aloe's clear gel on skin to treat burns, the skin condition psoriasis and even acne. Putting aloe gel on first- and second-degree burns and wounds may speed healing. Aloe extract cream might ease symptoms of mild to moderate psoriasis. Don't take aloe latex by mouth, as aloe latex may have cancer-causing chemicals. source↗
L5c Cleveland Clinic
Neutral
L5d Harvard Health
Cautious
L5e Specialty Society (condition-mapped)
Supportive