Magnesium for Premenstrual Syndrome
Verdict: Insufficient Evidence
Across 6 PubMed studies, the evidence for Magnesium in Premenstrual Syndrome grades Tier D — counter-evidence. Research is still too limited to draw a firm conclusion.
D 🔴 D Counter-Evidence Insufficient Evidence
Why this grade7-layer evidence engine
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Scoring transparency
All scores computed by a 7-layer evidence engine — fully auditableRaw score 0.33
D
C
B
A
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← counter-evidence / ineffectiveeffective / strong evidence →
Final grade
D · Insufficient Evidence
Confidence
85%
Highly consistent evidence
Evidence level
E2
Multiple high-quality MAs (≥2 independent, consistent)
▸View the full decision path (audit trail)
- compute_raw_score — 加權公式: L2×0.30 + L3×0.25 + L5×0.25 + L11×0.10 + L1×0.10 = 0.331
- tier_from_score — 依分數區間映射至 tier letter
- apply_hec_rules — 高階證據未達主導 (0 positive vs 1 negative)，由 raw_score 決定
- tier_strict_requirement_check — Tier 條件達標，未降階
- detect_disputes — 偵測到 0 個 hard + 0 個 soft dispute
- decide_status — 依 tier + dispute 結果決定 status
PubMed studies (6)L2 · primary research & systematic reviews
Effect of nutritional interventions on the psychological symptoms of premenstrual syndrome in women of reproductive age: a systematic review of randomized controlled trials
Finding: Across 31 RCTs (3254 participants), there was insufficient evidence to support an effect of magnesium on the psychological symptoms of PMS, whereas vitamin B6, calcium and zinc consistently showed significant positive effects.
View on PubMed The Association Between Serum Magnesium and Premenstrual Syndrome: a Systematic Review and Meta-Analysis of Observational Studies
Finding: Pooled across 13 observational studies, serum magnesium did not differ between PMS and controls in the follicular phase (WMD -0.04 mg/dL, 95% CI -0.14 to 0.06, p=0.46) or luteal phase overall (WMD -0.37, 95% CI -1.01 to 0.27, p=0.25).
View on PubMed Magnesium supplementation alleviates premenstrual symptoms of fluid retention
Finding: 200 mg/day magnesium (as MgO) showed no effect vs placebo in any symptom category in month 1; only fluid-retention symptoms (PMS-H) were significantly reduced in month 2 (p=0.009), with no benefit on anxiety, depression or total scores.
View on PubMed A synergistic effect of a daily supplement for 1 month of 200 mg magnesium plus 50 mg vitamin B6 for the relief of anxiety-related premenstrual symptoms: a randomized, double-blind, crossover study
Finding: A daily combination of 200 mg magnesium plus 50 mg vitamin B6 produced only a small synergistic reduction in anxiety-related premenstrual symptoms (p=0.040); magnesium alone showed no significant benefit and authors stressed further studies are needed.
View on PubMed Evaluating the effect of magnesium and magnesium plus vitamin B6 supplement on the severity of premenstrual syndrome
Finding: PMS scores fell significantly in ALL three arms including placebo (p<0.05); only the magnesium+B6 group was reported superior, and magnesium alone was not clearly separated from placebo, indicating a large placebo response.
View on PubMed Pilot study of the efficacy and safety of a modified-release magnesium 250 mg tablet (Sincromag) for the treatment of premenstrual syndrome
Finding: In this uncontrolled open-label pilot, mean total PMS score fell ~35.1% from baseline (p<0.0001), but with no placebo arm the result cannot be distinguished from placebo/regression effects.
View on PubMed Regulatory & authoritative positionsL4/L5 · FDA / EMA / NIH ODS / Cochrane / Mayo …
L4a US FDA
Supportive
NUTRIENT SUPPLEMENT source↗
L4b EU EFSA
Supportive
a cofactor of more than 300 enzymatic reactions source↗
L4c UK NHS
Cautious
You should be able to get all the magnesium you need by eating source↗
L4d TW TFDA / 衛福部
Supportive
每日食用量中鎂含量不超過600mg source↗
L4e WHO
Supportive
magnesium sulfate injections can be given to reduce the risk of eclampsia source↗
L5a NIH Office of Dietary Supplements
Supportive
Magnesium is a cofactor in more than 300 enzyme systems source↗
L5b Mayo Clinic
Cautious
Calcium, magnesium, vitamin E and vitamin B-6 have all been reported to soothe symptoms, but evidence is limited or lacking. source↗
L5c Cleveland Clinic
Cautious
Yes, magnesium can help with period cramps, although the effect may be small. There aren't any large studies looking at magnesium for cramps. Magnesium glycinate is the best type for cramps. It gets absorbed better and can be a little more effective. source↗
L5e Specialty Society (condition-mapped)
Cautious
Taking magnesium supplements may help reduce water retention ("bloating"), breast tenderness, and mood symptoms. Many products are advertised to help with PMS, but most of these products have either not been tested or have not been proved to be effective. It is important to talk with your ob-gyn before taking any PMS product or supplement. source↗