Mulberry Leaf Extract for NAFLD / MASLD
There is currently no human evidence that mulberry leaf extract treats non-alcoholic fatty liver disease (NAFLD/MASLD). Every supportive finding comes from animal or cell-based studies, so its benefit for the human liver remains unproven.
Why this grade7-layer evidence engine
This pairing is rated Unverified because all five available studies are preclinical, with zero human randomized trials measuring liver-specific outcomes. Mouse models consistently showed mulberry leaf preparations lowering liver fat and ALT/AST and easing inflammation (PMID 41431350, PMID 38488910, PMID 32948162), and a cell-line study found a DNJ-rich extract reduced fat accumulation in hepatocytes (PMID 41462942). One frequently grouped study (PMID 34035824) is actually an alcoholic-liver model, not NAFLD, so it does not even apply here.
The translational gap is the core problem. Animal and cell results often fail to reproduce in people, doses across the studies are inconsistent, and existing human mulberry trials looked at blood sugar rather than the liver. Regulators reflect this: the EU EFSA states a cause-and-effect relationship cannot be established and the extract is 'not sufficiently characterised,' while major clinics and the AASLD NAFLD guideline do not mention mulberry at all, recommending only vitamin E and pioglitazone.
A safety note matters because many people with NAFLD also have type 2 diabetes. The NIH/NCCIH cautions that white mulberry may lower blood glucose and warns of 'a potential risk for low blood sugar when taken with diabetes medications.' Until controlled human liver trials exist, mulberry leaf should not be relied on to treat fatty liver; proven steps are weight loss, a Mediterranean diet, and limiting alcohol.
Scoring transparency
All scores computed by a 7-layer evidence engine — fully auditable▸View the full decision path (audit trail)
- compute_raw_score — 加權公式: L2×0.30 + L3×0.25 + L5×0.25 + L11×0.10 + L1×0.10 = 0.44
- tier_from_score — 依分數區間映射至 tier letter
- apply_hec_rules — 僅有 E10 級證據 (cohort/animal/mechanism)，不足以下結論
- tier_strict_requirement_check — C 級條件未達 (需 E1-E8；實際 E10 僅機轉)
- detect_disputes — 偵測到 0 個 hard + 0 個 soft dispute
- decide_status — 依 tier + dispute 結果決定 status