Calcium D-Glucarate for Micronutrient Deficiency
Calcium D-glucarate is not a micronutrient and has no role in treating or preventing nutrient deficiency, so this pairing cannot be graded for efficacy. This is a category mismatch, not evidence that it "failed."
Why this grade7-layer evidence engine
Calcium D-glucarate is the calcium salt of D-glucaric acid, a non-essential plant compound studied as a beta-glucuronidase inhibitor that supports hepatic glucuronidation (a detox pathway). It is not classified as a vitamin, mineral, or essential nutrient by the IOM, EFSA, or WHO, and has no RDA, AI, or recognized deficiency syndrome. Because of this, asking whether it corrects "micronutrient deficiency" is a conceptual error rather than an open research question.
The evidence base reflects this directly: a targeted PubMed search returned zero clinical trials or reviews on the compound for nutrient deficiency. Health Canada licenses it only to "support glucuronidation, a liver detoxification pathway" — not for nutrition — while the US FDA merely lists it as a substance (no review or approval) and EFSA notes it is absent from the EU list of permitted calcium sources, so it cannot even be labeled as calcium. Mayo Clinic, Cleveland Clinic, and Harvard Health do not address it at all.
Accordingly the grade is U (Unverified): there is nothing assessable here, which is distinct from a compound being disproven. Anyone seeking to address a shortfall should use actual calcium or a multivitamin-mineral instead. Note that a 500 mg dose supplies only ~70 mg elemental calcium, far below adult needs, and the compound may speed clearance of drugs cleared via glucuronidation (e.g., oral contraceptives, tamoxifen, some statins).
Scoring transparency
All scores computed by a 7-layer evidence engine — fully auditable▸View the full decision path (audit trail)
- compute_raw_score — 加權公式: L2×0.30 + L3×0.25 + L5×0.25 + L11×0.10 + L1×0.10 = 0.455
- tier_from_score — 依分數區間映射至 tier letter
- apply_hec_rules — 僅有 E10 級證據 (cohort/animal/mechanism)，不足以下結論
- tier_strict_requirement_check — C 級條件未達 (需 E1-E8；實際 E10 僅機轉)
- detect_disputes — 偵測到 0 個 hard + 0 個 soft dispute
- decide_status — 依 tier + dispute 結果決定 status