Valerian for Menopause

Verdict: Weak, low-quality evidence; not recommended

A few small trials hint that valerian may ease menopausal hot flashes and sleep problems, but the evidence is too thin and low-quality to recommend it, and major menopause guidelines do not endorse it.

C 🟠 C Weak Evidence Taiwan Regulatory Restriction

🔬Why this grade7-layer evidence engine

The grade reflects a weak, shallow evidence base. Only three small randomized trials have tested valerian for menopause, all conducted in Iran by overlapping research groups. Two double-blind trials reported benefit versus placebo: one found reduced hot-flash severity (PMID 24250592, n=68, p<0.001) and one found better sleep quality on the PSQI, with 30% versus 4% of women improving (PMID 21775910, n=100, p<0.001).

The findings point in a consistent direction but are not convincing. None of the trials reported effect sizes, the samples are small and from a single region, and there is no meta-analysis or Cochrane review. The third trial (PMID 37160299, n=76) was open-label and tested a fennel-valerian combination, so its modest hot-flash and sleep benefits cannot be attributed to valerian alone.

Authorities do not back this use. The Menopause Society's 2023 guidance does not recommend herbal supplements for menopause, and the US FDA lists valerian only as a flavoring agent with no approved health claim, while EFSA has not authorized sleep claims. WHO recognizes valerian as a mild sedative for sleep but warns of drowsiness; because valerian can add to the sedative effect of alcohol, benzodiazepines, and other depressants, caution is warranted for menopausal women already taking sleep aids.

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Scoring transparency

All scores computed by a 7-layer evidence engine — fully auditable
Raw score 0.54
D
C
B
A
S
← counter-evidence / ineffectiveeffective / strong evidence →
Final grade
C · Taiwan Regulatory Restriction
Confidence
47%
Conflicting evidence
Evidence level
E6
Multiple smaller RCTs (n<500)

How strongly each layer supports this effect

lower = less supportive
L1 ExamineGlobal benchmark
0.50
L3 MechanismPlausibility
0.50
L11 AI re-checkIndependent read
0.50
L5 Clinical bodiesAuthoritative stance
0.55
L2 PubMedPrimary literature
0.60
Against Mixed Supports
View the full decision path (audit trail)
  1. compute_raw_score — 加權公式: L2×0.30 + L3×0.25 + L5×0.25 + L11×0.10 + L1×0.10 = 0.542
  2. tier_from_score — 依分數區間映射至 tier letter
  3. apply_hec_rules — 無高階證據可裁決
  4. tier_strict_requirement_check — Tier 條件達標,未降階
  5. detect_disputes — 偵測到 1 個 hard + 0 個 soft dispute
  6. decide_status — 依 tier + dispute 結果決定 status

📄PubMed studies (3)L2 · primary research & systematic reviews

The effects of valerian root on hot flashes in menopausal women
PMID: 24250592 2013 RCT (double-blind) n = 68
Finding: Hot flash severity significantly reduced post-treatment and vs placebo (p<0.001).
View on PubMed
Effect of valerian on sleep quality in postmenopausal women: a randomized placebo-controlled clinical trial
PMID: 21775910 2011 RCT (double-blind) n = 100
Finding: Sleep quality significantly improved vs placebo; 30% vs 4% improved (p<0.001).
Government
View on PubMed
Effect of Fennel-Valerian Extract on Hot Flashes and Sleep Disorders in Postmenopausal Women: A Randomized Trial
PMID: 37160299 2023 RCT (open-label) n = 76
Finding: Hot flashes lower (p<0.050) and PSQI improved (p=0.030) vs control at 2 months.
🟠 Limited quality Government
View on PubMed

🏛️Regulatory & authoritative positionsL4/L5 · FDA / EMA / NIH ODS / Cochrane / Mayo …

L4a US FDA
Neutral
Valerian Root Oil (Valeriana officinalis L.): 21 CFR 172.510; Used for: FLAVORING AGENT OR ADJUVANT; FEMA GRAS Publication No(s).: 3; FEMA No. 3100; CAS Reg. No. 8008-88-6. source↗
L4e WHO
Supportive
Medicinal uses. Uses supported by clinical data: As a mild sedative and sleep-promoting agent. The drug is often used as a milder alternative or a possible substitute for stronger synthetic sedatives, such as the benzodiazepines, in the treatment of states of nervous excitation and anxiety-induced sleep disturbances. Contraindications: Radix Valerianae should not be used during pregnancy or lac… source↗
PMID 100% verifiedevery citation checked via NCBI Entrez
🔬3 PubMed studiesindependently re-checked by multiple sub-agents
engine_version: v1.0 claim_id: CLM-COND-menopause-INT-valerian-001 繁體中文版 →