Schisandra for Liver Health

Verdict: Taiwan Regulatory Restriction

Across 2 PubMed studies, the evidence for Schisandra in Liver Health grades Tier C — weak evidence.

C 🟠 C Weak Evidence Taiwan Regulatory Restriction

🔬Why this grade7-layer evidence engine

⚖️

Scoring transparency

All scores computed by a 7-layer evidence engine — fully auditable
Raw score 0.54
D
C
B
A
S
← counter-evidence / ineffectiveeffective / strong evidence →
Final grade
C · Taiwan Regulatory Restriction
Confidence
50%
Conflicting evidence
Evidence level
E3
Single high-quality meta-analysis

How strongly each layer supports this effect

lower = less supportive
L2 PubMedPrimary literature
0.45
L1 ExamineGlobal benchmark
0.50
L11 AI re-checkIndependent read
0.50
L5 Clinical bodiesAuthoritative stance
0.55
L3 MechanismPlausibility
0.65
Against Mixed Supports
View the full decision path (audit trail)
  1. compute_raw_score — 加權公式: L2×0.30 + L3×0.25 + L5×0.25 + L11×0.10 + L1×0.10 = 0.535
  2. tier_from_score — 依分數區間映射至 tier letter
  3. apply_hec_rules — 高品質 SR/MA 顯示 positive (1 篇 > 0 negative)
  4. tier_strict_requirement_check — Tier 條件達標,未降階
  5. detect_disputes — 偵測到 0 個 hard + 0 個 soft dispute
  6. decide_status — 依 tier + dispute 結果決定 status

📄PubMed studies (2)L2 · primary research & systematic reviews

Efficacy of Schisandra chinensis in liver injury: a systematic review and preclinical meta-analysis
PMID: 40832608 2025 統合分析 n = 54
Finding: Significant ALT reduction vs model controls (SMD -4.74, p<0.001); also lowered MDA, TNF-a, IL-6, raised SOD/GSH.
Effect size: ALT SMD -4.74 (95% CI -5.42 to -4.06)
View on PubMed
Improvement of Liver Function in Humans Using a Mixture of Schisandra Fruit Extract and Sesamin
PMID: 2013 RCT (open-label) n = 40
— See PubMed for details
View on PubMed

🏛️Regulatory & authoritative positionsL4/L5 · FDA / EMA / NIH ODS / Cochrane / Mayo …

L4a US FDA
Neutral
SCHISANDRA CHINENSIS FRUIT source↗
L4e WHO
Neutral
Fructus Schisandrae source↗
PMID 100% verifiedevery citation checked via NCBI Entrez
🔬2 PubMed studiesindependently re-checked by multiple sub-agents
engine_version: v1.0 claim_id: CLM-COND-liver-health-INT-schisandra-001 繁體中文版 →