D-Mannose for Kidney Disease
No clinical studies have tested oral D-mannose supplements as a treatment for kidney disease, so its benefit cannot be claimed. The grade reflects an absence of relevant evidence, not proof that it works or that it has been disproven for this use.
Why this grade7-layer evidence engine
This pairing earns an Unverified grade because no trial has ever measured oral D-mannose against any kidney-disease outcome (eGFR, proteinuria, CKD progression, or acute kidney injury). The only randomized data, the Manotras pilot in 60 kidney-transplant recipients (PMID 38637262), tested D-mannose plus proanthocyanidins for urinary tract infection prophylaxis, found no benefit, and reported no kidney-function endpoints.
The wider D-mannose trial base targets UTIs, not the kidneys: a 2025 meta-analysis of six RCTs (PMID 41004704, n=1167) found it did not reduce recurrent UTIs versus control or antibiotics. The one paper directly linking mannose to the kidney is a Mendelian randomization analysis (PMID 38354117) suggesting higher endogenous serum mannose is associated with worse CKD outcomes. That signal points opposite to the consumer hope of kidney protection, but it concerns the body's own metabolite, not a swallowed supplement, so it neither proves harm nor disproves a benefit.
Authoritative bodies are silent on this specific use. FDA action and an EFSA rejection both concern UTI claims, NHS frames D-mannose as a non-prescription sugar rather than a medicine, and the NIH ODS, Mayo Clinic, Cleveland Clinic, Harvard Health, and kidney specialty societies do not address it for kidney disease. Because D-mannose is cleared by the kidneys, several sources advise people with reduced kidney function to consult a clinician before use, but this is precautionary opinion, not trial evidence.
Scoring transparency
All scores computed by a 7-layer evidence engine — fully auditable▸View the full decision path (audit trail)
- compute_raw_score — 加權公式: L2×0.30 + L3×0.25 + L5×0.25 + L11×0.10 + L1×0.10 = 0.443
- tier_from_score — 依分數區間映射至 tier letter
- apply_hec_rules — 高階證據未達主導 (0 positive vs 1 negative)，由 raw_score 決定
- tier_strict_requirement_check — | C→U 因 scope.conflation_risk=true 且 L11 獨評較低 (B7-2 tier cap)
- detect_disputes — 偵測到 0 個 hard + 0 個 soft dispute
- decide_status — 依 tier + dispute 結果決定 status