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Coriolus versicolor (PSK/PSP) for Immune Function

Verdict: Published

Across 4 PubMed studies, the evidence for Coriolus versicolor (PSK/PSP) in Immune Function grades Tier C — weak evidence.

C 🟠 C Weak Evidence Published

🔬Why this grade7-layer evidence engine

⚖️

Scoring transparency

All scores computed by a 7-layer evidence engine — fully auditable
Raw score 0.57
D
C
B
A
S
← counter-evidence / ineffectiveeffective / strong evidence →
Final grade
C · Published
Confidence
47%
Conflicting evidence
Evidence level
E2
Multiple high-quality MAs (≥2 independent, consistent)

How strongly each layer supports this effect

lower = less supportive
L1 ExamineGlobal benchmark
0.50
L5 Clinical bodiesAuthoritative stance
0.50
L11 AI re-checkIndependent read
0.50
L2 PubMedPrimary literature
0.60
L3 MechanismPlausibility
0.65
Against Mixed Supports
▸View the full decision path (audit trail)
  1. compute_raw_score — 加權公式: L2×0.30 + L3×0.25 + L5×0.25 + L11×0.10 + L1×0.10 = 0.568
  2. tier_from_score — 依分數區間映射至 tier letter
  3. apply_hec_rules — 高品質 SR/MA 顯示 positive (3 篇 > 0 negative)
  4. tier_strict_requirement_check — | B→C 因 scope.conflation_risk=true 且 L11 獨評較低 (B7-2 tier cap)
  5. detect_disputes — 偵測到 0 個 hard + 0 個 soft dispute
  6. decide_status — 依 tier + dispute 結果決定 status

📄PubMed studies (4)L2 · primary research & systematic reviews

Phase 1 Clinical Trial of Trametes versicolor in Women with Breast Cancer
PMID: 22701186 2012 RCT (open-label) n = 9
Finding: Dose-related increases in lymphocyte counts (6-9 g/day), NK functional activity (6 g/day), CD8+ T cells and CD19+ B cells after post-radiotherapy supplementation; no p-values reported (phase I).
🟠 Limited quality Government
View on PubMed
Trametes versicolor (Synn. Coriolus versicolor) Polysaccharides in Cancer Therapy: Targets and Efficacy
PMID: 32466253 2020 系統性回顧
Finding: Consistent upregulation of IL-2/IL-12/IFN-γ and NK/lymphocyte counts across trials; meta-analytic 9% absolute reduction in 5-year mortality in adjuvant cancer setting.
Academic Effect size: 5y mortality ARR ~9%
View on PubMed
Immunomodulatory Properties of Coriolus versicolor: The Role of Polysaccharopeptide
PMID: 28932226 2017 系統性回顧
Finding: PSP increased NK cytotoxic function and lymphocyte counts in breast cancer patients; healthy donors showed increased IFN-γ and Th cell counts (qualitative synthesis).
Mixed funding
View on PubMed
Can polysaccharide K improve therapeutic efficacy and safety in gastrointestinal cancer? a systematic review and network meta-analysis
PMID: 29179503 2017 統合分析 n = 10,684
Finding: PSK + chemo improved 3y OS (OR 1.54, 95% CI 1.18-2.13) and 5y OS (OR 2.94, 95% CI 1.00-8.33); reduced leukopenia (OR 0.60) — indirect immune-preservation signal.
🟢 High quality Effect size: 3y OS OR 1.54 (1.18-2.13)
View on PubMed

🏛️Regulatory & authoritative positionsL4/L5 · FDA / EMA / NIH ODS / Cochrane / Mayo …

L4a US FDA
Cautious
Turkey tail are known to have anti-cancer, antiviral, antibacterial and antifungal effects as well as immune modulating effects. ... The claims on your website establish that your products are drugs under section 201(g)(1)(B) of the FD&C Act because they were intended for use in the cure, mitigation, treatment, or prevention of disease. source↗
L4b EU EFSA
Against
Commission Implementing Decision of 6 December 2021 (C(2021) 8744 final) terminating the procedure for authorising the placing on the market within the Union of the novel food 'Coriolus versicolor' without updating the Union list of novel foods pursuant to Regulation (EU) 2015/2283. source↗
✓PMID 100% verifiedevery citation checked via NCBI Entrez
🔬4 PubMed studiesindependently re-checked by multiple sub-agents
engine_version: v1.0 claim_id: CLM-COND-immune-function-INT-coriolus-versicolor-001 繁體中文版 →