Creatine for Fibromyalgia
Verdict: Published with Warning
Across 4 PubMed studies, the evidence for Creatine in Fibromyalgia grades Tier C — weak evidence. Effective, but with safety or population caveats.
C 🟠 C Weak Evidence Published with Warning
Why this grade7-layer evidence engine
⚖️
Scoring transparency
All scores computed by a 7-layer evidence engine — fully auditableRaw score 0.50
D
C
B
A
S
← counter-evidence / ineffectiveeffective / strong evidence →
Final grade
C · Published with Warning
Confidence
85%
Highly consistent evidence
Evidence level
E2
Multiple high-quality MAs (≥2 independent, consistent)
▸View the full decision path (audit trail)
- compute_raw_score — 加權公式: L2×0.30 + L3×0.25 + L5×0.25 + L11×0.10 + L1×0.10 = 0.502
- tier_from_score — 依分數區間映射至 tier letter
- apply_hec_rules — 無高階證據可裁決
- tier_strict_requirement_check — Tier 條件達標，未降階
- detect_disputes — 偵測到 0 個 hard + 0 個 soft dispute
- decide_status — 依 tier + dispute 結果決定 status
PubMed studies (4)L2 · primary research & systematic reviews
Creatine supplementation in fibromyalgia: a randomized, double-blind, placebo-controlled trial
Finding: Creatine raised intramuscular phosphorylcreatine (+80.3% vs -2.7%, p=0.04) and improved leg-press strength (+9.8% vs -0.5%, p=0.02), but produced NO significant change in pain, sleep, cognition, aerobic capacity, or quality of life.
View on PubMed Dietary Supplements for Pain Relief in Patients with Fibromyalgia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Finding: Dietary supplements as a class modestly reduced fibromyalgia pain (SMD 1.23, 95% CI 0.02-2.43, p=0.046) but did not improve quality of life (SMD 0.73, 95% CI -0.07-1.53, p=0.075); authors caution that few trials, high heterogeneity, and unstable evidence prevent firm conclusions.
View on PubMed An open-label study adding creatine monohydrate to ongoing medical regimens in patients with the fibromyalgia syndrome
Finding: After 8 weeks of add-on creatine, severity, pain, sleep, quality of life, and disability all improved significantly and worsened again 4 weeks after stopping, but the study was uncontrolled (no placebo), small, and had a high dropout rate, so the effect cannot be attributed to creatine.
View on PubMed Beyond the Pain: A Systematic Narrative Review of the Latest Advancements in Fibromyalgia Treatment
Finding: This 2023 narrative review only lists creatine in a table of dietary supplements that have been 'studied' for fibromyalgia and offers no efficacy verdict, so it adds context but no creatine-specific evidence.
View on PubMed Regulatory & authoritative positionsL4/L5 · FDA / EMA / NIH ODS / Cochrane / Mayo …
L4a US FDA
Supportive
FDA has no questions source↗
L4b EU EFSA
Supportive
cause and effect relationship has been established source↗
L4c UK NHS
Not addressed
Supplements containing creatine are widely used by athletes to improve performance source↗
L5a NIH Office of Dietary Supplements
Supportive
May increase strength, power source↗
L5c Cleveland Clinic
Supportive
In addition to its athletic benefits, creatine supplements may benefit people who have: Neurodegenerative diseases, such as muscular dystrophy, Parkinson's disease and Huntington's disease. Diabetes. Osteoarthritis. Fibromyalgia. Conditions that affect creatine metabolism. Conditions that affect how creatine transports through your body. Insufficient blood flow to your heart muscle (myocardial … source↗