Royal Jelly for Fatigue
Verdict: Insufficient Evidence
Across 2 PubMed studies, the evidence for Royal Jelly in Fatigue grades Tier U — unverified / insufficient. Research is still too limited to draw a firm conclusion.
U ⚫ U Unverified Insufficient Evidence
Why this grade7-layer evidence engine
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Scoring transparency
All scores computed by a 7-layer evidence engine — fully auditableRaw score 0.44
D
C
B
A
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← counter-evidence / ineffectiveeffective / strong evidence →
Final grade
U · Insufficient Evidence
Confidence
74%
Broadly consistent
Evidence level
E6
Multiple smaller RCTs (n<500)
▸View the full decision path (audit trail)
- compute_raw_score — 加權公式: L2×0.30 + L3×0.25 + L5×0.25 + L11×0.10 + L1×0.10 = 0.44
- tier_from_score — 依分數區間映射至 tier letter
- apply_hec_rules — 無高階證據可裁決
- tier_strict_requirement_check — Tier 條件達標，未降階
- detect_disputes — 偵測到 0 個 hard + 0 個 soft dispute
- decide_status — 依 tier + dispute 結果決定 status
PubMed studies (2)L2 · primary research & systematic reviews
Oral Intake of Royal Jelly Has Protective Effects Against Tyrosine Kinase Inhibitor-Induced Toxicity in Patients with Renal Cell Carcinoma
Finding: Fatigue frequency significantly lower in RJ vs placebo (p=0.003); anorexia also lower (p=0.015); dose-reduction / discontinuation-free interval longer in RJ group (p=0.013). Population is advanced RCC on TKI — not general healthy adults.
View on PubMed Effect of Processed Honey and Royal Jelly on Cancer-Related Fatigue: A Double-Blind Randomized Clinical Trial
Finding: Processed honey + RJ group showed significant fatigue reduction vs pure honey at week 2 and week 4 (p<0.001 both timepoints). Effect sizes not reported in abstract. Cancer-related fatigue population (not general fatigue).
View on PubMed Regulatory & authoritative positionsL4/L5 · FDA / EMA / NIH ODS / Cochrane / Mayo …
L4a US FDA
Cautious
Anna Health, LLC — Fresh Royal Jelly (non-freeze dried) marketed with anti-depression claims and immune-boost claims against Coronavirus / Influenza / Bronchitis / Common Cold are 「new drugs」 under section 201(p) of the FD&C Act because they are not generally recognized as safe and effective for the referenced uses. source↗
L4b EU EFSA
Against
On the basis of the data presented, the Panel concludes that a cause and effect relationship has not been established between the consumption of royal jelly and the claimed effects. source↗
L4c UK NHS
Against
Royal jelly, bee pollen and propolis can cause severe allergic reactions, including anaphylaxis, particularly in people with asthma or other allergies. There is no good evidence that these products provide health benefits, and they should be avoided by anyone with a history of allergic reactions to bee stings or bee products. source↗
L4d TW TFDA / 衛福部
Cautious
蜂王乳（蜂王漿）：類別「昆蟲及其來源製取之原料」，屬「可供食品使用之原料」，使用類型為營養添加，無特定每日攝取限量規定，業者應適量添加。我國衛生福利部將蜂王乳視為一般食品原料。 source↗
L5a NIH Office of Dietary Supplements
Cautious
people with pollen allergies may have allergic reactions to bee products, such as bee pollen, honey, royal jelly, and propolis. Royal jelly is generally well tolerated without adverse events except for rare allergic reactions particularly in patients with a history of asthma or atopic disease. source↗