Urolithin A for Endurance
Urolithin A has not been shown to reliably improve endurance: across four small trials the pre-specified performance endpoints consistently failed, and only softer secondary measures moved. Treat any "boosts endurance" marketing with skepticism.
Why this grade7-layer evidence engine
The grade is C (weak, disputed) because the human evidence is thin and internally split. Four double-blind RCTs (total n is roughly 216) share the same telltale pattern: the main outcome each trial set out to move did not budge. Peak cycling power was not met in middle-aged adults (PMID 35584623), the 6-minute walk distance was not significant in older adults (PMID 35050355), and a 3000 m time trial did not improve in highly trained runners (PMID 40839339, p=0.116).
What did move were secondary and biomarker measures, pointing in a broadly favorable direction: within-group VO2 and strength gains (PMID 35584623), better muscle endurance (PMID 35050355), lower perceived exertion and reduced muscle-damage markers (PMID 40839339), and more reps to failure in a small resistance-training trial (PMID 39487653). These signals are encouraging but exploratory, and the smallest study (n=20) was low quality with undisclosed funding. At least three of the four trials were funded by the manufacturer, which is why the engine attaches an industry conflict-of-interest flag.
Regulators (FDA, EFSA, Australia's TGA, Health Canada) have addressed only food safety, clearing intake up to about 500 mg/day, and have approved no endurance or performance claim. No clinical authority weighs in either: NIH ODS, Mayo, Cleveland and Harvard are silent, and sports-science bodies (ACSM, IOC, ISSN, AIS) have not placed Urolithin A in any evidence category. That gap, combined with the null primary endpoints, keeps this honestly at weak/disputed.
Scoring transparency
All scores computed by a 7-layer evidence engine — fully auditable▸View the full decision path (audit trail)
- compute_raw_score — 加權公式: L2×0.30 + L3×0.25 + L5×0.25 + L11×0.10 + L1×0.10 = 0.503
- tier_from_score — 依分數區間映射至 tier letter
- apply_hec_rules — 無高階證據可裁決
- tier_strict_requirement_check — Tier 條件達標，未降階
- detect_disputes — 偵測到 1 個 hard + 1 個 soft dispute
- decide_status — 依 tier + dispute 結果決定 status