Lactobacillus paracasei (K71 / LP33) for Common Cold
Verdict: Insufficient Evidence
Across 3 PubMed studies, the evidence for Lactobacillus paracasei (K71 / LP33) in Common Cold grades Tier U — unverified / insufficient. Research is still too limited to draw a firm conclusion.
U ⚫ U Unverified Insufficient Evidence
Why this grade7-layer evidence engine
⚖️
Scoring transparency
All scores computed by a 7-layer evidence engine — fully auditableRaw score 0.41
D
C
B
A
S
← counter-evidence / ineffectiveeffective / strong evidence →
Final grade
U · Insufficient Evidence
Confidence
73%
Broadly consistent
Evidence level
E3
Single high-quality meta-analysis
▸View the full decision path (audit trail)
- compute_raw_score — 加權公式: L2×0.30 + L3×0.25 + L5×0.25 + L11×0.10 + L1×0.10 = 0.406
- tier_from_score — 依分數區間映射至 tier letter
- apply_hec_rules — 無高階證據可裁決
- tier_strict_requirement_check — | C→U 因 scope.conflation_risk=true 且 L11 獨評較低 (B7-2 tier cap)
- detect_disputes — 偵測到 0 個 hard + 1 個 soft dispute
- decide_status — 依 tier + dispute 結果決定 status
PubMed studies (3)L2 · primary research & systematic reviews
Effect of long term consumption of a probiotic milk on infections in children attending day care centres (Hatakka et al.)
Finding: Children receiving LGG milk had fewer days of respiratory infection (mean reduction ~17%; RR 0.83, 95% CI 0.71-0.96) and reduced antibiotic use vs placebo.
View on PubMed Randomised, double-blind, placebo-controlled study using new probiotic lactobacilli for strengthening the body immune defence against viral infections (Berggren et al.)
Finding: Probiotic group had reduced cold incidence (0.9 vs 1.0 episodes; p=0.069 trend) and significantly fewer symptom days (6.2 vs 8.6 days, p=0.0481); shorter pharyngeal symptom duration.
View on PubMed Probiotics for preventing acute upper respiratory tract infections
Finding: Probiotics probably reduce number of people with acute URTIs (OR 0.24, 95% CI 0.15-0.37; moderate-certainty evidence) and mean URTI duration (MD -1.22 days, 95% CI -2.12 to -0.33); strain-specific data sparse.
View on PubMed Regulatory & authoritative positionsL4/L5 · FDA / EMA / NIH ODS / Cochrane / Mayo …
L5a NIH Office of Dietary Supplements
Cautious
A review of 23 studies (1,919 participants) in which probiotics were tested for treating allergic rhinitis found some evidence that they may be helpful for improving symptoms and quality of life... because the studies tested different probiotics and measured different effects, no recommendations about the use of probiotics could be made. source↗
L5e Specialty Society (condition-mapped)
Not addressed