Spermidine for Cognitive Function
Verdict: Taiwan Regulatory Restriction
Across 5 PubMed studies, the evidence for Spermidine in Cognitive Function grades Tier C — weak evidence.
C 🟠 C Weak Evidence Taiwan Regulatory Restriction
Why this grade7-layer evidence engine
⚖️
Scoring transparency
All scores computed by a 7-layer evidence engine — fully auditableRaw score 0.61
D
C
B
A
S
← counter-evidence / ineffectiveeffective / strong evidence →
Final grade
C · Taiwan Regulatory Restriction
Confidence
85%
Highly consistent evidence
Evidence level
E2
Multiple high-quality MAs (≥2 independent, consistent)
▸View the full decision path (audit trail)
- compute_raw_score — 加權公式: L2×0.30 + L3×0.25 + L5×0.25 + L11×0.10 + L1×0.10 = 0.613
- tier_from_score — 依分數區間映射至 tier letter
- apply_hec_rules — 高品質 SR/MA 顯示 positive (1 篇 > 0 negative)
- tier_strict_requirement_check — Tier 條件達標，未降階
- detect_disputes — 偵測到 1 個 hard + 0 個 soft dispute
- decide_status — 依 tier + dispute 結果決定 status
PubMed studies (5)L2 · primary research & systematic reviews
The effect of spermidine on memory performance in older adults at risk for dementia: A randomized controlled trial
Finding: Spermidine group showed moderately enhanced memory performance and mnemonic discrimination vs placebo (Cohen's d = 0.77 and 0.79 respectively); no comparable change in placebo. Positive pilot signal.
View on PubMed Effects of Spermidine Supplementation on Cognition and Biomarkers in Older Adults With Subjective Cognitive Decline (SmartAge): A Randomized Clinical Trial
Finding: No significant between-group difference on primary outcome at 12 months (adjusted treatment effect -0.03; 95% CI, -0.11 to 0.05; p=0.47). Null result — failed to confirm pilot.
View on PubMed Spermidine in dementia: Relation to age and memory performance
Finding: Significant positive correlation between serum spermidine and MMSE score (p=0.025); proposed as candidate biomarker for neurocognitive change. Hypothesis-generating only.
View on PubMed Spermidine for cognitive ageing: insights into observational and interventional studies
Finding: 3 of 4 interventional trials suggest cognitive benefit but the largest, well-powered 12-month SmartAge RCT showed no benefit at low dose. Observational data mixed: some link higher serum SPD to better MMSE, others to reduced hippocampal volume. Authors stress measurement heterogeneity and dose uncertainty; evidence not yet sufficient for clinical recommendation.
View on PubMed The Effect of Spermidine Supplementation on Cognitive Function in Adults: A Mini-Review
— See PubMed for details
View on PubMed Regulatory & authoritative positionsL4/L5 · FDA / EMA / NIH ODS / Cochrane / Mayo …
L4a US FDA
Neutral
At the notifier's request, FDA ceased to evaluate this notice source↗
L4b EU EFSA
Cautious
Equivalent of max. 6 mg/day spermidine; Food supplements as defined in Directive 2002/46/EC, excluding food supplements for infants, young children, children, adolescents, pregnant and lactating women. The designation of the novel food on the labelling of the foodstuffs containing it shall be 'spermidine-rich wheat germ extract'. source↗
L4e WHO
Cautious
Spermidine [in Spermidine trihydrochloride] ... This ingredient cannot be used in natural health products without the submission of additional evidence for safety. source↗
L5e Specialty Society (condition-mapped)
Not addressed
Not a single food, beverage, ingredient, vitamin or supplement has been proven to prevent, treat or cure Alzheimer's disease. source↗