Lion's Mane for Cognitive Function
Lion's Mane shows only a faint, inconsistent cognitive signal in a handful of small, mostly industry-funded trials, and no benefit has been established. Health authorities and major clinics agree the human evidence is too thin to recommend it for brain health.
Why this grade7-layer evidence engine
The grade rests on just four small, low-quality randomized trials (n=18-41), nearly all single-site and mostly industry-funded, with no meta-analysis to anchor a stronger verdict. The most cited, Mori 2009 (PMID 18844328), found higher cognitive scores in adults with mild cognitive impairment at weeks 8-16, but the benefit faded within four weeks of stopping, so it was neither durable nor clearly generalizable to healthy people.
Results in healthy adults are mixed and underpowered. A 2023 pilot (PMID 38004235) saw faster acute Stroop reaction times but only a non-significant trend for stress (p=0.051), and a 2025 acute trial (PMID 40276537) found no effect on global cognition, with an isolated psychomotor improvement only. An earlier trial (PMID 31413233) improved MMSE alone while other measures stayed flat.
Regulators and clinicians reinforce the caution. The FDA ceased evaluating the GRAS notice and has sent warning letters to sellers making disease claims, while EFSA has not endorsed any claim. Mayo Clinic and Harvard Health call the human evidence insufficient or poor quality, Cleveland Clinic notes the nerve-growth-factor mechanism comes only from non-human studies, and the Alzheimer's Association says no supplement is proven to benefit cognition. Hence a weak, warning-flagged C.
Scoring transparency
All scores computed by a 7-layer evidence engine — fully auditable▸View the full decision path (audit trail)
- compute_raw_score — 加權公式: L2×0.30 + L3×0.25 + L5×0.25 + L11×0.10 + L1×0.10 = 0.48
- tier_from_score — 依分數區間映射至 tier letter
- apply_hec_rules — 無高階證據可裁決
- tier_strict_requirement_check — Tier 條件達標，未降階
- detect_disputes — 偵測到 0 個 hard + 1 個 soft dispute
- decide_status — 依 tier + dispute 結果決定 status