Fisetin for Cognitive Function
There is currently no human trial evidence that fisetin improves cognitive function or prevents dementia; all supporting data come from mouse studies, and major regulators and clinics do not endorse this use.
Why this grade7-layer evidence engine
This claim is graded Unverified because every cited study is preclinical, with zero published human randomized trials measuring cognitive outcomes. Four mouse experiments report benefit: nano-fisetin eased memory deficits and lowered TNF-alpha/IL-6 in amyloid-beta mice over three weeks (PMID 39552578); fisetin reduced cognitive decline in rapidly aging SAMP8 mice over 28 weeks (PMID 28575152); and it preserved learning and memory in transgenic Alzheimer's mice over 36 weeks (PMID 24341874). A related review covers the fisetin derivative CMS121 but reports no human cognition data (PMID 39422940).
Animal results do not transfer reliably to people, and a practical gap compounds the uncertainty: the preclinical doses (roughly 5-25 mg/kg) far exceed typical human supplement doses, and fisetin is poorly absorbed orally. Ongoing early-phase human trials have not yet reported cognitive results.
Authorities reinforce the cautious grade. The FDA issued a warning letter over illegal disease claims for a fisetin product, and Health Canada permits only a basic antioxidant claim at 100 mg/day, not any anti-aging or cognitive use. Mayo Clinic explicitly argues against using commercial fisetin, and the Alzheimer's Association states no supplement has been proven to benefit cognitive function or brain health.
Scoring transparency
All scores computed by a 7-layer evidence engine — fully auditable▸View the full decision path (audit trail)
- compute_raw_score — 加權公式: L2×0.30 + L3×0.25 + L5×0.25 + L11×0.10 + L1×0.10 = 0.415
- tier_from_score — 依分數區間映射至 tier letter
- apply_hec_rules — 僅有 E10 級證據 (cohort/animal/mechanism)，不足以下結論
- tier_strict_requirement_check — C 級條件未達 (需 E1-E8；實際 E10 僅機轉)
- detect_disputes — 偵測到 0 個 hard + 0 個 soft dispute
- decide_status — 依 tier + dispute 結果決定 status