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Antrodia cinnamomea for Cancer Adjunct Therapy

Verdict: Disputed

Across 4 PubMed studies, the evidence for Antrodia cinnamomea in Cancer Adjunct Therapy grades Tier U — unverified / insufficient. High-quality studies disagree — the evidence is genuinely mixed.

U ⚫ U Unverified Disputed

🔬Why this grade7-layer evidence engine

⚖️

Scoring transparency

All scores computed by a 7-layer evidence engine — fully auditable
Raw score 0.42
D
C
B
A
S
← counter-evidence / ineffectiveeffective / strong evidence →
Final grade
U · Disputed
Confidence
69%
Broadly consistent
Evidence level
E6
Multiple smaller RCTs (n<500)

How strongly each layer supports this effect

lower = less supportive
L11 AI re-checkIndependent read
0.20
L2 PubMedPrimary literature
0.40
L1 ExamineGlobal benchmark
0.50
L3 MechanismPlausibility
0.50
L5 Clinical bodiesAuthoritative stance
0.50
Against Mixed Supports
▸View the full decision path (audit trail)
  1. compute_raw_score — 加權公式: L2×0.30 + L3×0.25 + L5×0.25 + L11×0.10 + L1×0.10 = 0.418
  2. tier_from_score — 依分數區間映射至 tier letter
  3. apply_hec_rules — 無高階證據可裁決
  4. tier_strict_requirement_check — | C→U 因 scope.conflation_risk=true 且 L11 獨評較低 (B7-2 tier cap)
  5. detect_disputes — 偵測到 1 個 hard + 1 個 soft dispute
  6. decide_status — 依 tier + dispute 結果決定 status

📄PubMed studies (4)L2 · primary research & systematic reviews

A preliminary randomised controlled study of short-term Antrodia cinnamomea treatment combined with chemotherapy for advanced cancer
PMID: 27565426 2016 RCT (double-blind) n = 37
Finding: Mean OS 5.4 mo (AC) vs 5.0 mo (placebo), p=0.340; no significant benefit, and AC group had lower platelet counts (p=0.02).
🟠 Limited quality Effect size: MD +0.4 months OS (NS)
View on PubMed
A phase I multicenter study of antroquinonol in patients with metastatic NSCLC after ≥2 prior systemic regimens
PMID: 26807250 2015 RCT (open-label) n = 13
Finding: No DLTs at any dose; RP2D ≥600 mg/day; most common AEs diarrhea, vomiting, nausea (mild). No efficacy endpoint met (Phase I).
🟠 Limited quality ⚠️ Industry-funded
View on PubMed
Antrodia Cinnamomea Prolongs Survival in a Patient with Small Cell Lung Cancer
PMID: 31561410 2019 個案報告 n = 1
Finding: Single SCLC patient: tumor shrank 17.26×9.78 cm → 8.89×3.90 cm; survived 32 months. Anecdotal only, no causal inference possible.
🟠 Limited quality
View on PubMed
Phase I/II study of antroquinonol + nab-paclitaxel + gemcitabine in metastatic pancreatic cancer (NCT03310632)
PMID: 2024 RCT (open-label) n = 55
— See PubMed for details
View on PubMed

🏛️Regulatory & authoritative positionsL4/L5 · FDA / EMA / NIH ODS / Cochrane / Mayo …

L4a US FDA
Cautious
cancer fighting properties source↗
L4b EU EFSA
Cautious
The Panel concludes that the NF, freeze-dried mycelia of Antrodia camphorata, is safe at the proposed use level for individuals aged 14 years and above. ... maximum dose of 990 mg per day ... in food supplements as defined in Directive 2002/46/EC ... for the general population. source↗
✓PMID 100% verifiedevery citation checked via NCBI Entrez
🔬4 PubMed studiesindependently re-checked by multiple sub-agents
engine_version: v1.0 claim_id: CLM-COND-cancer-adjunct-INT-antrodia-cinnamomea-001 繁體中文版 →