Pumpkin Seed Oil for Androgenetic Alopecia
Verdict: Published
Across 4 PubMed studies, the evidence for Pumpkin Seed Oil in Androgenetic Alopecia grades Tier C — weak evidence.
C 🟠 C Weak Evidence Published
Why this grade7-layer evidence engine
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Scoring transparency
All scores computed by a 7-layer evidence engine — fully auditableRaw score 0.58
D
C
B
A
S
← counter-evidence / ineffectiveeffective / strong evidence →
Final grade
C · Published
Confidence
75%
Broadly consistent
Evidence level
E2
Multiple high-quality MAs (≥2 independent, consistent)
▸View the full decision path (audit trail)
- compute_raw_score — 加權公式: L2×0.30 + L3×0.25 + L5×0.25 + L11×0.10 + L1×0.10 = 0.58
- tier_from_score — 依分數區間映射至 tier letter
- apply_hec_rules — 高品質 SR/MA 顯示 positive (2 篇 > 0 negative)
- tier_strict_requirement_check — | B→C 因 scope.conflation_risk=true 且 L11 獨評較低 (B7-2 tier cap)
- detect_disputes — 偵測到 0 個 hard + 0 個 soft dispute
- decide_status — 依 tier + dispute 結果決定 status
PubMed studies (4)L2 · primary research & systematic reviews
Effects of dietary supplements on androgenetic alopecia: a systematic review and network meta-analysis
Finding: Pumpkin seed oil significantly increased hair density vs placebo (SMD = 0.59 hairs/cm2, 95% CI 0.09 to 1.09; CI excludes zero), but supplements as a class did not surpass first-line drugs and are positioned only as adjuncts/alternatives.
View on PubMed Evaluation of the Safety and Effectiveness of Nutritional Supplements for Treating Hair Loss: A Systematic Review
Finding: Listed pumpkin seed oil among supplements with the highest-quality available evidence showing potential benefit, but explicitly cautioned that findings must be interpreted within each study's design and stopped short of recommending supplements over standard therapy.
View on PubMed Effect of Pumpkin Seed Oil on Hair Growth in Men with Androgenetic Alopecia: A Randomized, Double-Blind, Placebo-Controlled Trial
Finding: Mean hair count rose 40% in the treatment arm vs 10% on placebo at 24 weeks (P<0.001), but the capsule was a multi-ingredient product (Octa Sabal Plus), not pure pumpkin seed oil, so the benefit cannot be attributed to PSO alone.
View on PubMed Pumpkin seed oil vs. minoxidil 5% topical foam for the treatment of female pattern hair loss: A randomized comparative trial
Finding: Both arms improved within-group (PSO hair-shaft diversity 30.5%->24.0%, P<0.001; minoxidil 31.5%->21.3%, P<0.001), but no direct between-group statistical comparison was reported and there was no placebo arm, so non-inferiority to minoxidil is unproven.
View on PubMed Regulatory & authoritative positionsL4/L5 · FDA / EMA / NIH ODS / Cochrane / Mayo …
L4a US FDA
Neutral
PUMPKIN SEED OIL — CAS Registry Number: 8016-49-7 — Regulatory Citation: 175.300 source↗
L4b EU EFSA
Against
a cause and effect relationship has not been established between the consumption of a combination of thiamin, riboflavin, niacin, pantothenic acid, pyridoxine, D-biotin and pumpkin seed oil (Cucurbita pepo L.) and maintenance of normal hair source↗
L4d TW TFDA / 衛福部
Neutral
南瓜籽油（Cucurbita moschata Duchesne 種子榨取之油脂）列於可供食品使用之原料；健康食品可宣稱之保健功效共 13 項，未包含『攝護腺保健』或『改善下泌尿道症狀』。 source↗