Resveratrol for Aging
Resveratrol has not been shown to slow aging or extend life in people; human trials are null on most outcomes, and high doses may even raise cardiovascular risk markers. The famous longevity findings come from yeast and mice, not humans.
Why this grade7-layer evidence engine
This rates as Counter-Evidence because the human data actively fail to support an anti-aging benefit, rather than simply being thin. No clinical trial has ever tested lifespan or a hard aging endpoint. A 2012 cross-species meta-analysis (PMID 22718956) found life extension only in yeast and nematodes, with effects shrinking and turning inconsistent in higher organisms, and its authors warned against extrapolating to people.
Controlled human studies are largely null. A 2021 systematic review and meta-analysis (PMID 33303422) bluntly framed resveratrol as a 'cognitive enhancer for mice only,' finding no significant effect on cognition, mood, grey-matter volume, or blood pressure. A 2024 systematic review (PMID 38433010) found resveratrol alone ineffective across conditions, with benefit appearing only when paired with exercise. More concerning, a double-blind RCT (PMID 31891746) showed 1000 mg/day raised cardiovascular risk biomarkers (sVCAM-1, tPAI-1) in overweight older adults.
Regulators and clinics align with this caution. The US FDA has not authorized any anti-aging health claim and ceased evaluating its GRAS notice at the notifier's request, and EFSA found no cause-and-effect for any resveratrol claim. The Mayo Clinic notes it 'was very helpful for mice' but 'is not the bright, shining star' in humans, while Harvard and the National Institute on Aging position is explicitly against it. Poor oral bioavailability further undercuts the supplement's plausibility.
Scoring transparency
All scores computed by a 7-layer evidence engine — fully auditable▸View the full decision path (audit trail)
- compute_raw_score — 加權公式: L2×0.30 + L3×0.25 + L5×0.25 + L11×0.10 + L1×0.10 = 0.381
- tier_from_score — 依分數區間映射至 tier letter
- apply_hec_rules — 高階證據未達主導 (0 positive vs 1 negative)，由 raw_score 決定
- tier_strict_requirement_check — Tier 條件達標，未降階
- detect_disputes — 偵測到 0 個 hard + 1 個 soft dispute
- decide_status — 依 tier + dispute 結果決定 status