Bilberry for Vision / Eye Health

Verdict: Weak, conflicting evidence for eye health

Bilberry does not reliably improve vision: the strongest evidence shows no benefit for night vision in healthy people, and the only positive findings are small, industry-funded, and limited to subjective eye-fatigue symptoms. It is not a substitute for routine eye care.

C 🟠 C Weak Evidence Published with Warning

🔬Why this grade7-layer evidence engine

The grade is weak (Tier C) because the evidence is thin and points in opposite directions. The strongest source, a systematic review of placebo-controlled trials (PMID 15530951), pooled four rigorous RCTs in people with normal vision and found the long-standing claim that bilberry sharpens night vision is not supported; all four high-quality trials were negative across every night-vision endpoint.

The positive signals are weak and indirect. A double-blind RCT in screen workers (PMID 25923485) reported only a modest drop in subjective eye-fatigue symptoms and a small flicker-fusion change, with no improvement in measured visual acuity; it was small, industry-funded, and low quality. A separate meta-analysis (PMID 28825651) confirmed anthocyanins can improve blood-vessel function, but its authors stress this circulatory effect is the proposed, not proven, route to any eye benefit.

Authorities mirror this uncertainty rather than endorse the supplement. The US FDA has engaged bilberry only through warning letters against unproven eye claims, and EU regulators authorise no vision health claim. The WHO monograph lists ophthalmic use only within a traditional-medicine framework, while NIH and major clinics stay cautious or silent. Heavy industry funding behind the positive trials and a possible blood-thinning interaction further lower confidence.

⚖️

Scoring transparency

All scores computed by a 7-layer evidence engine — fully auditable
Raw score 0.42
D
C
B
A
S
← counter-evidence / ineffectiveeffective / strong evidence →
Final grade
C · Published with Warning
Confidence
72%
Broadly consistent
Evidence level
E2
Multiple high-quality MAs (≥2 independent, consistent)

How strongly each layer supports this effect

lower = less supportive
L5 Clinical bodiesAuthoritative stance
0.40
L2 PubMedPrimary literature
0.45
L3 MechanismPlausibility
0.45
L1 ExamineGlobal benchmark
0.50
L11 AI re-checkIndependent read
0.50
Against Mixed Supports
View the full decision path (audit trail)
  1. compute_raw_score — 加權公式: L2×0.30 + L3×0.25 + L5×0.25 + L11×0.10 + L1×0.10 = 0.425
  2. tier_from_score — 依分數區間映射至 tier letter
  3. apply_hec_rules — 高品質 SR/MA 顯示 positive (1 篇 > 0 negative)
  4. tier_strict_requirement_check — Tier 條件達標,未降階
  5. detect_disputes — 偵測到 0 個 hard + 1 個 soft dispute
  6. decide_status — 依 tier + dispute 結果決定 status

📄PubMed studies (3)L2 · primary research & systematic reviews

Anthocyanosides of Vaccinium myrtillus (bilberry) for night vision--a systematic review of placebo-controlled trials
PMID: 15530951 2004 系統性回顧 n = 149
Finding: Canter & Ernst SR of 12 placebo-controlled trials (4 rigorous RCTs in healthy subjects) found that the hypothesis bilberry improves normal night vision is not supported; all 4 RCTs of highest methodological quality reported negative results (p>0.05 for all night-vision endpoints).
🟢 High quality Academic
View on PubMed
The Effect of Anthocyanin-Rich Foods or Extracts on Vascular Function in Adults: A Systematic Review and Meta-Analysis of Randomised Controlled Trials
PMID: 28825651 2017 統合分析
Finding: Meta-analysis found anthocyanin extracts improved flow-mediated dilation (WMD ~3.35%, p<0.001); authors note the vascular-perfusion mechanism is the proposed but unproven pathway for bilberry's putative ocular benefit.
Academic
View on PubMed
Bilberry extract supplementation for preventing eye fatigue in video display terminal workers
PMID: 25923485 2015 RCT (double-blind) n = 88
Finding: RCT in VDT workers reported a modest reduction in asthenopia symptom score and improvement in critical flicker fusion (p<0.05) after 8 weeks of bilberry vs placebo; the effect on objective visual acuity was non-significant.
🟠 Limited quality ⚠️ Industry-funded
View on PubMed

🏛️Regulatory & authoritative positionsL4/L5 · FDA / EMA / NIH ODS / Cochrane / Mayo …

L4a US FDA
Cautious
The studies [of Bilberry] reveal that blood vessels are strengthened, circulation improves, blood glucose levels may be lowered, prevention of cell damage are all benefits that Bilberry may provide. source↗
L4b EU EFSA
Neutral
L4d TW TFDA / 衛福部
Neutral
目前公告之健康食品保健功效共有13項:護肝、抗疲勞、調節血脂、調節血糖、免疫調節、骨質保健、牙齒保健、延緩衰老、促進鐵吸收、胃腸功能改善、輔助調節血壓、不易形成體脂肪、輔助調整過敏體質。(衛福部食藥署「健康食品概說暨導覽」) source↗
L4e WHO
Supportive
Uses supported by clinical data: Oral use for the symptomatic treatment of dysmenorrhoea associated with premenstrual syndrome, circulatory disorders in patients with capillary leakage or peripheral vascular insufficiency and ophthalmic disorders. Uses described in pharmacopoeias and well established documents: Oral use for the treatment of acute diarrhoea and local irritation or inflammation o… source↗
L5a NIH Office of Dietary Supplements
Cautious
L5c Cleveland Clinic
Cautious
PMID 100% verifiedevery citation checked via NCBI Entrez
🔬3 PubMed studiesindependently re-checked by multiple sub-agents
engine_version: v1.0 claim_id: CLM-COND-vision-INT-bilberry-001 繁體中文版 →