Mulberry Leaf Extract for Type 2 Diabetes
Verdict: Published with Warning
Across 5 PubMed studies, the evidence for Mulberry Leaf Extract in Type 2 Diabetes grades Tier C — weak evidence. Effective, but with safety or population caveats.
C 🟠 C Weak Evidence Published with Warning
Why this grade7-layer evidence engine
⚖️
Scoring transparency
All scores computed by a 7-layer evidence engine — fully auditableRaw score 0.61
D
C
B
A
S
← counter-evidence / ineffectiveeffective / strong evidence →
Final grade
C · Published with Warning
Confidence
76%
Broadly consistent
Evidence level
E3
Single high-quality meta-analysis
▸View the full decision path (audit trail)
- compute_raw_score — 加權公式: L2×0.30 + L3×0.25 + L5×0.25 + L11×0.10 + L1×0.10 = 0.613
- tier_from_score — 依分數區間映射至 tier letter
- apply_hec_rules — 高品質 SR/MA 顯示 positive (1 篇 > 0 negative)
- tier_strict_requirement_check — Tier 條件達標，未降階
- detect_disputes — 偵測到 1 個 hard + 0 個 soft dispute
- decide_status — 依 tier + dispute 結果決定 status
PubMed studies (5)L2 · primary research & systematic reviews
Mulberry-extract improves glucose tolerance and decreases insulin concentrations in normoglycaemic adults
Finding: Mulberry extract significantly reduced postprandial glucose iAUC by 42% and insulin iAUC by 41% vs placebo (p<0.001) in normoglycaemic adults.
View on PubMed A mulberry leaf extract inhibits sucrase activity and suppresses postprandial blood glucose response
Finding: Mulberry leaf extract significantly suppressed postprandial glucose and insulin elevation after sucrose load vs placebo (p<0.05), consistent with alpha-glucosidase inhibition.
View on PubMed Impact of mulberry leaf extract on type 2 diabetes (Mul-DM): A randomized, placebo-controlled pilot study
Finding: In T2DM patients, mulberry leaf extract showed a trend toward improved postprandial glucose; no statistically significant change in HbA1c at 12 weeks (small sample).
View on PubMed Influence of mulberry leaf extract on the blood glucose and breath hydrogen response to ingestion of 75 g sucrose
Finding: Mulberry leaf extract significantly reduced postprandial glucose rise and increased breath hydrogen, confirming alpha-glucosidase inhibition mechanism (DNJ).
View on PubMed Morus alba L. for Blood Sugar Management: A Systematic Review and Meta-Analysis
Finding: Phimarn et al. SR/MA found mulberry leaf reduced fasting glucose and postprandial glucose; HbA1c effect inconsistent and based on few small RCTs; overall evidence quality low to moderate.
View on PubMed Regulatory & authoritative positionsL4/L5 · FDA / EMA / NIH ODS / Cochrane / Mayo …
L4a US FDA
Cautious
L4b EU EFSA
Not addressed
A cause and effect relationship cannot be established between the consumption of Morus alba (white mulberry) leaf extract and the claimed effect. The mulberry extract is not sufficiently characterised in relation to the claimed effect. The proposed target population of diabetic patients does not comply with the criteria for disease risk reduction claims. source↗
L4d TW TFDA / 衛福部
Supportive
本產品經動物實驗結果證實：有助於延緩飯後血糖上升，僅供參考。本產品經動物實驗結果證實：有助於降低體脂肪形成（不易形成體脂肪），僅供參考。 source↗
L5a NIH Office of Dietary Supplements
Cautious
Several studies suggest that white mulberry may reduce elevated blood glucose levels, but some of these studies have been preliminary or were not conducted in humans. Other trials have found no effect on blood glucose levels. There is a potential risk for low blood sugar when taken with diabetes medications. source↗