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GABA (gamma-Aminobutyric Acid) for Stress

Verdict: Published with Warning

Across 3 PubMed studies, the evidence for GABA (gamma-Aminobutyric Acid) in Stress grades Tier C — weak evidence. Effective, but with safety or population caveats.

C 🟠 C Weak Evidence Published with Warning

🔬Why this grade7-layer evidence engine

⚖️

Scoring transparency

All scores computed by a 7-layer evidence engine — fully auditable
Raw score 0.55
D
C
B
A
S
← counter-evidence / ineffectiveeffective / strong evidence →
Final grade
C · Published with Warning
Confidence
85%
Highly consistent evidence
Evidence level
E3
Single high-quality meta-analysis

How strongly each layer supports this effect

lower = less supportive
L1 ExamineGlobal benchmark
0.50
L11 AI re-checkIndependent read
0.50
L5 Clinical bodiesAuthoritative stance
0.55
L2 PubMedPrimary literature
0.60
L3 MechanismPlausibility
0.65
Against Mixed Supports
▸View the full decision path (audit trail)
  1. compute_raw_score — 加權公式: L2×0.30 + L3×0.25 + L5×0.25 + L11×0.10 + L1×0.10 = 0.551
  2. tier_from_score — 依分數區間映射至 tier letter
  3. apply_hec_rules — 高品質 SR/MA 顯示 positive (1 篇 > 0 negative)
  4. tier_strict_requirement_check — Tier 條件達標，未降階
  5. detect_disputes — 偵測到 0 個 hard + 1 個 soft dispute
  6. decide_status — 依 tier + dispute 結果決定 status

📄PubMed studies (3)L2 · primary research & systematic reviews

Effects of Oral Gamma-Aminobutyric Acid (GABA) Administration on Stress and Sleep in Humans: A Systematic Review
PMID: 33041752 2020 系統性回顧
Finding: Limited evidence for stress benefits; acute studies show increased alpha and alpha/beta ratio suggesting relaxation, but heterogeneity prevented meta-analysis.
Academic
View on PubMed
Relaxation and immunity enhancement effects of gamma-aminobutyric acid (GABA) administration in humans
PMID: 16971751 2006 RCT (open-label) n = 13
Finding: GABA significantly increased alpha waves and decreased beta waves vs water or L-theanine at 60 min; companion arm (n=8) showed maintained salivary IgA under acrophobic stress.
🟠 Limited quality ⚠️ Industry-funded
View on PubMed
Effects of L-theanine or caffeine intake on changes in blood pressure under physical and psychological stresses
PMID: 23107346 2012 RCT (double-blind) n = 16
Finding: Stress task decreased alpha and beta power; 30 min after 100 mg GABA this decrease was diminished vs placebo, indicating a stress-protective EEG signal.
🟠 Limited quality ⚠️ Industry-funded
View on PubMed

🏛️Regulatory & authoritative positionsL4/L5 · FDA / EMA / NIH ODS / Cochrane / Mayo …

L4a US FDA
Cautious
4-AMINOBUTYRIC ACID — CAS Reg. No. 56-12-2; other names GAMMA-AMINOBUTYRIC ACID, GABA; Permitted Technical Effect: FLAVORING AGENT OR ADJUVANT; FEMA No. 4288; FEMA GRAS Publication No. 23; JECFA Flavor No. 1771. source↗
L4d TW TFDA / 衛福部
Neutral
γ-胺基丁酸含量，不得低於20%；其每日食用限量，以γ-胺基丁酸計為100 mg。標示「使用本產品應避免同時飲酒或服用降血壓、鎮靜及癲癇等藥物；孕婦、授乳者、嬰幼兒，須諮詢醫師方可使用」。 source↗
✓PMID 100% verifiedevery citation checked via NCBI Entrez
🔬3 PubMed studiesindependently re-checked by multiple sub-agents
engine_version: v1.0 claim_id: CLM-COND-stress-INT-gamma-aminobutyric-acid-001 繁體中文版 →