Grape Seed Extract for Skin Aging
Verdict: Insufficient Evidence
Across 3 PubMed studies, the evidence for Grape Seed Extract in Skin Aging grades Tier U — unverified / insufficient. Research is still too limited to draw a firm conclusion.
U ⚫ U Unverified Insufficient Evidence
Why this grade7-layer evidence engine
⚖️
Scoring transparency
All scores computed by a 7-layer evidence engine — fully auditableRaw score 0.46
D
C
B
A
S
← counter-evidence / ineffectiveeffective / strong evidence →
Final grade
U · Insufficient Evidence
Confidence
77%
Broadly consistent
Evidence level
E7
Single small RCT
▸View the full decision path (audit trail)
- compute_raw_score — 加權公式: L2×0.30 + L3×0.25 + L5×0.25 + L11×0.10 + L1×0.10 = 0.455
- tier_from_score — 依分數區間映射至 tier letter
- apply_hec_rules — 無高階證據可裁決
- tier_strict_requirement_check — Tier 條件達標，未降階
- detect_disputes — 偵測到 0 個 hard + 0 個 soft dispute
- decide_status — 依 tier + dispute 結果決定 status
PubMed studies (3)L2 · primary research & systematic reviews
Oral intake of proanthocyanidin-rich extract from grape seeds improves chloasma
Finding: After 6 months, chloasma improved or slightly improved in 10 of 12 women (83%, p<0.01); melanin index fell significantly (0.025 to 0.019, p<0.01). During a further 5 months, improvement was seen in 6 of 11 (54%, p<0.01). Authors conclude grape seed extract is safe and useful for improving chloasma.
View on PubMed Beneficial effects of proanthocyanidins on skin aging: a review
— See PubMed for details
View on PubMed Assessment of clinical effects and safety of an oral supplement based on marine protein, vitamin C, grape seed extract, zinc, and tomato extract in the improvement of visible signs of skin aging in…
Finding: Daily oral supplementation with the marine-protein/vitamin C/grape seed extract/zinc/tomato extract complex showed improvement in dermal density and facial hydration with increases in collagen and elastic fibers. Because grape seed extract is bundled with four other actives, the effect attributable to grape seed extract alone cannot be determined.
View on PubMed Regulatory & authoritative positionsL4/L5 · FDA / EMA / NIH ODS / Cochrane / Mayo …
L4a US FDA
Cautious
OPCs also act as a natural histamine and can be helpful treating allergies, asthma, bronchitis, arthritis, muscle tissue injuries and ulcers source↗
L4b EU EFSA
Against
L4d TW TFDA / 衛福部
Neutral
葡萄（學名：Vitis vinifera L.）之種子及果皮可供食品使用，其所含前（原）花青素（proanthocyanidin）每日最高攝食量為 150 毫克。 source↗
L5a NIH Office of Dietary Supplements
Cautious
L5e Specialty Society (condition-mapped)
Not addressed