Bitter Melon Peptide (mcIRBP-19 / MAP30) for Obesity
Bitter melon peptide is not an evidence-based treatment for obesity: there are essentially no peptide-specific human weight-loss trials, and the broader bitter melon evidence consistently shows no meaningful effect on body weight or body fat.
Why this grade7-layer evidence engine
This earns a Counter-Evidence (D) grade chiefly because the marketed ingredient is a bitter melon peptide (mcIRBP-19/BmpP), yet no human trial has tested that peptide for obesity. The only peptide-specific RCT (PMID 32354072, n=42, industry-funded) measured blood sugar in people with diabetes, not body weight, so peptide-for-weight-loss evidence is effectively zero.
Stepping back to whole bitter melon, three meta-analyses converge on the same null result. Two 2024 analyses found no significant change in body weight, BMI, waist circumference, or body fat (PMID 39079610, n=448; PMID 38274207, n=414), with the latter concluding the metabolic effect 'cannot be determined' given short trials and very high heterogeneity. A small 2022 pilot in patients with obesity also showed no anthropometric change (PMID 35507955).
Authorities reinforce this. The US FDA warned that a bitter melon blood-sugar supplement is 'not generally recognized as safe and effective,' the NIH notes only a modest glucose effect with little impact on key markers, and the WHO, Mayo Clinic, Harvard, and obesity-medicine societies do not list it for weight management. Most trials also carry industry funding, further weakening confidence.
Scoring transparency
All scores computed by a 7-layer evidence engine — fully auditable▸View the full decision path (audit trail)
- compute_raw_score — 加權公式: L2×0.30 + L3×0.25 + L5×0.25 + L11×0.10 + L1×0.10 = 0.406
- tier_from_score — 依分數區間映射至 tier letter
- apply_hec_rules — 高品質 SR/MA 顯示 negative 主導 (3 negative > 0 positive)，下層 RCT 不能推翻
- apply_hec_override — HEC-1 高階證據 negative — 強制由 C 改為 D
- tier_strict_requirement_check — Tier 條件達標，未降階
- detect_disputes — 偵測到 0 個 hard + 1 個 soft dispute
- decide_status — 依 tier + dispute 結果決定 status