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Magnesium for Migraine

Verdict: Published with Warning

Across 4 PubMed studies, the evidence for Magnesium in Migraine grades Tier A — moderate evidence. Effective, but with safety or population caveats.

A 🔵 A Moderate Evidence Published with Warning

🔬Why this grade7-layer evidence engine

⚖️

Scoring transparency

All scores computed by a 7-layer evidence engine — fully auditable
Raw score 0.62
D
C
B
A
S
← counter-evidence / ineffectiveeffective / strong evidence →
Final grade
A · Published with Warning
Confidence
86%
Highly consistent evidence
Evidence level
E2
Multiple high-quality MAs (≥2 independent, consistent)

How strongly each layer supports this effect

lower = less supportive
L1 ExamineGlobal benchmark
0.50
L2 PubMedPrimary literature
0.60
L3 MechanismPlausibility
0.65
L5 Clinical bodiesAuthoritative stance
0.65
L11 AI re-checkIndependent read
0.65
Against Mixed Supports
▸View the full decision path (audit trail)
  1. compute_raw_score — 加權公式: L2×0.30 + L3×0.25 + L5×0.25 + L11×0.10 + L1×0.10 = 0.62
  2. tier_from_score — 依分數區間映射至 tier letter
  3. apply_hec_rules — 高品質 SR/MA 顯示 positive (1 篇 > 0 negative)
  4. tier_strict_requirement_check — Tier 條件達標，未降階
  5. detect_disputes — 偵測到 0 個 hard + 1 個 soft dispute
  6. decide_status — 依 tier + dispute 結果決定 status

📄PubMed studies (4)L2 · primary research & systematic reviews

Effects of selected dietary supplements on migraine prophylaxis: A systematic review and dose-response meta-analysis of randomized controlled trials
PMID: 39404918 2025 統合分析
Finding: Magnesium significantly reduced migraine attack frequency (MD = -2.51 attacks), severity (MD = -0.88), and monthly migraine days (MD = -1.66) versus control, with GRADE certainty assessed but confidence intervals not extractable from the available abstract.
Effect size: MD = -2.51 attacks (frequency); MD = -0.88 (severity); MD = -1.66 monthly migraine days; 95% CIs not available in abstract
View on PubMed
Vitamins and Minerals for Migraine Prophylaxis: A Systematic Review and Meta-analysis
PMID: 30764890 2019 統合分析 n = 226
Finding: Magnesium was NOT significantly associated with reduced migraine severity (RoM -0.17, 95% CI -0.36 to 0.02; 3 trials, 226 participants; I2 48%; low strength of evidence), and frequency could not be pooled (I2 88%); authors concluded evidence is insufficient to know if magnesium is effective.
Academic Effect size: RoM -0.17 (95% CI -0.36 to 0.02) for severity; non-significant; frequency not poolable (I2 88%, 4 trials, 266 participants)
View on PubMed
Comparative study of magnesium, sodium valproate, and concurrent magnesium-sodium valproate therapy in the prevention of migraine headaches: a randomized controlled double-blind trial
PMID: 33827421 2021 RCT (double-blind) n = 260
Finding: Magnesium oxide 250 mg twice daily reduced attacks from 7.06 to 3.91/month but was clearly inferior to sodium valproate (6.65 to 1.60), and adding magnesium to valproate gave no benefit over valproate alone (1.40 vs 1.60, p = 0.525).
Government Effect size: Magnesium arm: 7.06 to 3.91 attacks/month; valproate arm: 6.65 to 1.60; magnesium+valproate vs valproate p = 0.525 (NS)
View on PubMed
Prophylaxis of migraine with oral magnesium: results from a prospective, multi-center, placebo-controlled and double-blind randomized study
PMID: 8792038 1996 RCT (double-blind) n = 81
Finding: Trimagnesium dicitrate 600 mg/day reduced attack frequency by 41.6% versus 15.8% with placebo (p < 0.05) over 12 weeks, but caused diarrhea in 18.6% of patients.
Effect size: -41.6% attack frequency vs -15.8% placebo (p < 0.05)
View on PubMed

🏛️Regulatory & authoritative positionsL4/L5 · FDA / EMA / NIH ODS / Cochrane / Mayo …

L4a US FDA
Supportive
NUTRIENT SUPPLEMENT source↗
L4b EU EFSA
Supportive
a cofactor of more than 300 enzymatic reactions source↗
L4c UK NHS
Cautious
You should be able to get all the magnesium you need by eating source↗
L4d TW TFDA / 衛福部
Supportive
每日食用量中鎂含量不超過600mg source↗
L4e WHO
Supportive
magnesium sulfate injections can be given to reduce the risk of eclampsia source↗
L5a NIH Office of Dietary Supplements
Supportive
Magnesium is a cofactor in more than 300 enzyme systems source↗
L5b Mayo Clinic
Cautious
Magnesium supplements could help increase your body's stores of magnesium and might also help reduce muscle and migraine pain. However, further research is needed before it can be called a cure to everything from constipation to low energy levels. Magnesium supplements are typically well tolerated, especially when you take the supplement in small doses. source↗
L5c Cleveland Clinic
Supportive
A dose of magnesium can protect against these auras, and we often advise patients to take magnesium when they experience their aura. Magnesium is also good for reducing migraine auras. source↗
L5d Harvard Health
Cautious
For some conditions, such as insomnia or migraine headaches, a magnesium supplement may be worth a try. source↗
L5e Specialty Society (condition-mapped)
Supportive
In 2012, the American Headache Society and the American Academy of Neurology reviewed the studies on medications used for migraine prevention and gave magnesium a Level B rating; that is, it is probably effective and should be considered for patients requiring migraine preventive therapy. source↗
✓PMID 100% verifiedevery citation checked via NCBI Entrez
🔬4 PubMed studiesindependently re-checked by multiple sub-agents
engine_version: v1.0 claim_id: CLM-COND-migraine-INT-magnesium-001 繁體中文版 →