Coenzyme Q10 for Migraine
Coenzyme Q10 appears to modestly reduce how often migraines occur, but the effect is small and the overall evidence is still preliminary, so it is best viewed as an optional add-on rather than a proven, stand-alone treatment.
Why this grade7-layer evidence engine
Two recent meta-analyses anchor the positive signal: Sazali 2021 (PMID 33402403; 6 trials, n=371) found about 1.5 fewer migraine days per month (MD -1.52, 95% CI -2.40 to -0.65, p<0.001) and a small drop in attack duration, while Parohan 2020 (PMID 30727862; 4 trials, n=221) reported roughly 1.9 fewer attacks per month (WMD -1.87, p<0.001). Supporting RCTs (PMID 29298622; PMID 30612463; PMID 25916335) point the same direction.
The grade stays at preliminary rather than strong because the benefit is genuinely modest and inconsistent across endpoints. Both meta-analyses found that attack severity did not improve significantly, several supportive trials were tiny or combined CoQ10 with L-carnitine or riboflavin and magnesium (PMID 30612463; PMID 25916335) rather than testing it alone, and some included studies had drug-manufacturer funding.
Authorities are cautious and not aligned. The US FDA treats disease claims for CoQ10 as unapproved 'new drugs,' the EU EFSA concluded a cause-and-effect relationship has not been established, and the UK NHS/NICE recommends riboflavin for migraine while not listing CoQ10. Mayo Clinic and Cleveland Clinic say it 'might' or 'may' help and note it can take 2-3 months to judge; warfarin users, pregnant or breastfeeding people, and children should use caution.
Scoring transparency
All scores computed by a 7-layer evidence engine — fully auditable▸View the full decision path (audit trail)
- compute_raw_score — 加權公式: L2×0.30 + L3×0.25 + L5×0.25 + L11×0.10 + L1×0.10 = 0.604
- tier_from_score — 依分數區間映射至 tier letter
- apply_hec_rules — 高品質 SR/MA 顯示 positive (2 篇 > 0 negative)
- tier_strict_requirement_check — Tier 條件達標，未降階
- detect_disputes — 偵測到 0 個 hard + 0 個 soft dispute
- decide_status — 依 tier + dispute 結果決定 status