Royal Jelly for Menopause
Royal jelly shows a small, preliminary signal for easing menopausal symptoms such as hot flashes, but the overall evidence is thin and major regulators have not endorsed it. People with asthma or bee allergies should avoid it because of a real risk of severe allergic reactions.
Why this grade7-layer evidence engine
The grade reflects a genuine but fragile positive signal. The strongest study is a double-blind RCT (PMID 31470366, n=200, 1000 mg/day for 8 weeks) that found royal jelly significantly reduced hot-flash frequency and night-sweat severity versus placebo (P<0.05), with a favorable safety profile. A smaller open-label arm (n=55) reported modest drops in depression and irritability scores, and a 2026 systematic review (PMID 41401249) described a consistent but modest effect.
It stays at a preliminary tier rather than higher because the evidence base is small and heterogeneous: only one trial exceeded 100 participants, doses ranged widely (150-1000 mg/day), outcome scales differed between studies, follow-up was 12 weeks or less, and no Cochrane review or pooled meta-analysis exists. The 2026 review itself mixed in honey and propolis and called for larger high-quality trials.
Authorities lean negative or silent. The EU EFSA formally concluded that a cause-and-effect relationship has not been established for royal jelly's claimed effects, the UK NHS says there is no good evidence of benefit, and Harvard Health and The Menopause Society hold that no supplement is proven effective for menopause relief. Combined with documented anaphylaxis risk flagged by the NHS and NIH ODS, especially in asthma or bee-allergic people, plus possible drug interactions, this claim is marked for safety review.
Scoring transparency
All scores computed by a 7-layer evidence engine — fully auditable▸View the full decision path (audit trail)
- compute_raw_score — 加權公式: L2×0.30 + L3×0.25 + L5×0.25 + L11×0.10 + L1×0.10 = 0.568
- tier_from_score — 依分數區間映射至 tier letter
- apply_hec_rules — 無高階證據可裁決
- tier_strict_requirement_check — Tier 條件達標，未降階
- detect_disputes — 偵測到 0 個 hard + 0 個 soft dispute
- decide_status — 依 tier + dispute 結果決定 status