Vitamin K for Masld
There is not enough evidence to say vitamin K treats MASLD (metabolic dysfunction-associated steatotic liver disease). The only human data are observational and cannot show cause and effect, so vitamin K should not be used as a therapy for fatty liver.
Why this grade7-layer evidence engine
This claim is rated Unverified because the evidence sits at the lowest tier. No randomized controlled trials, Cochrane reviews, or meta-analyses have tested whether vitamin K improves MASLD. The strongest human data are two NHANES population studies: a 2025 prospective cohort of 7,857 NAFLD patients linking higher dietary vitamin K to lower all-cause mortality with a threshold near 121 mcg/day (PMID 40456852), and a 2023 cross-sectional study (n=3,571) associating higher intake with lower MAFLD risk (PMID 37305083). A 2024 mouse study suggests vitamin K2 protects against diet-induced fatty liver (PMID 38321064).
Observational signals like these cannot prove causation. People who eat more vitamin K (leafy greens) tend to have healthier diets overall, and the 121 mcg/day threshold roughly matches the adult adequate intake, so the finding may simply reflect generally healthier eaters rather than a treatment effect of the vitamin itself.
Regulators and clinics back this caution. The FDA, EFSA, NHS, and WHO authorize vitamin K only for blood clotting, bone maintenance, and newborn bleeding prophylaxis, not for liver disease. Mayo Clinic, Cleveland Clinic, Harvard Health, and the AASLD and EASL liver-disease guidelines do not list vitamin K for MASLD; Mayo even notes liver disease may raise the risk of side effects. Anyone on warfarin should keep vitamin K intake steady, as supplements can interfere with the drug.
Scoring transparency
All scores computed by a 7-layer evidence engine — fully auditable▸View the full decision path (audit trail)
- compute_raw_score — 加權公式: L2×0.30 + L3×0.25 + L5×0.25 + L11×0.10 + L1×0.10 = 0.573
- tier_from_score — 依分數區間映射至 tier letter
- apply_hec_rules — 僅有 E8 級證據 (cohort/animal/mechanism)，不足以下結論
- apply_hec_override — HEC-4 僅低階證據 (E8-E10) — 強制由 B 改為 U
- tier_strict_requirement_check — Tier 條件達標，未降階
- detect_disputes — 偵測到 0 個 hard + 0 個 soft dispute
- decide_status — 依 tier + dispute 結果決定 status