Maca for Male Infertility

Verdict: Weak, inconsistent evidence; likely no real benefit

Maca has not been shown to reliably improve male fertility: the best available pooled evidence found no statistically significant effect on sperm concentration, and the overall data are too small and conflicting to support its use for male infertility.

C 🟠 C Weak Evidence Published with Warning

🔬Why this grade7-layer evidence engine

This claim is graded Weak (Tier C) because, although a few small trials hint at benefit, the highest-quality evidence does not hold up. A 2022 systematic review and meta-analysis pooling five randomized trials found no significant improvement in sperm concentration versus placebo (WMD 2.22, 95% CI -2.94 to 7.37, p=0.4) and only mixed effects on motility (PMID 36110519).

The underlying trials are small and contradict one another. One double-blind RCT (n=69) did report a significant rise in sperm concentration (p=0.011) but no change in motility, morphology, or semen volume (PMID 32654242). Against this, a trial in infertile men (n=50) found placebo numerically outperformed maca and that free testosterone actually fell on maca (PMID 34585449), while a 20-man pilot showed only nonsignificant trends (PMID 26421049). An often-cited 2001 report was an uncontrolled cohort of just 9 men (PMID 11753476).

Regulators add caution rather than support. The US FDA found that 'Peru Maca' products were spiked with hidden sildenafil (the active drug in Viagra) and advised consumers not to use them, and major health bodies such as the NHS and WHO do not address maca for fertility at all. Hormone levels were unchanged across trials, so no clear mechanism supports an effect.

⚖️

Scoring transparency

All scores computed by a 7-layer evidence engine — fully auditable
Raw score 0.63
D
C
B
A
S
← counter-evidence / ineffectiveeffective / strong evidence →
Final grade
C · Published with Warning
Confidence
63%
Broadly consistent
Evidence level
E3
Single high-quality meta-analysis

How strongly each layer supports this effect

lower = less supportive
L1 ExamineGlobal benchmark
0.50
L11 AI re-checkIndependent read
0.50
L5 Clinical bodiesAuthoritative stance
0.55
L3 MechanismPlausibility
0.65
L2 PubMedPrimary literature
0.75
Against Mixed Supports
View the full decision path (audit trail)
  1. compute_raw_score — 加權公式: L2×0.30 + L3×0.25 + L5×0.25 + L11×0.10 + L1×0.10 = 0.625
  2. tier_from_score — 依分數區間映射至 tier letter
  3. apply_hec_rules — 高階證據未達主導 (0 positive vs 1 negative),由 raw_score 決定
  4. tier_strict_requirement_check — | B→C 因 scope.conflation_risk=true 且 L11 獨評較低 (B7-2 tier cap)
  5. detect_disputes — 偵測到 0 個 hard + 0 個 soft dispute
  6. decide_status — 依 tier + dispute 結果決定 status

📄PubMed studies (5)L2 · primary research & systematic reviews

Maca (Lepidium meyenii Walp.) on semen quality parameters: A systematic review and meta-analysis
PMID: 36110519 2022 統合分析
Finding: No significant benefit vs placebo for sperm concentration (WMD 2.22, 95% CI -2.94 to 7.37, p=0.4); mixed effects on motility; unclear overall efficacy.
Academic Effect size: WMD 2.22 (95% CI -2.94 to 7.37) for sperm concentration
View on PubMed
Evaluation of the effect of Lepidium meyenii Walpers in infertile patients: A randomized, double-blind, placebo-controlled trial
PMID: 34585449 2021 RCT (double-blind) n = 50
Finding: Maca improved sperm concentration by 40% vs 76% with placebo at 8 and 16 weeks; results statistically non-significant. Free testosterone decreased with maca.
🟠 Limited quality Academic Effect size: +40% sperm concentration vs +76% placebo (non-significant)
View on PubMed
Does Lepidium meyenii (Maca) improve seminal quality?
PMID: 32654242 2020 RCT (double-blind) n = 69
Finding: Sperm concentration significantly improved (15.04 vs 10.16 x10^6/mL, p=0.011); no significant differences in semen volume (p=.392), motility (p=.462), or morphology (p=.801).
Effect size: Sperm concentration MD ~4.88 x10^6/mL (p=0.011)
View on PubMed
Effect of Lepidium meyenii Walp. on Semen Parameters and Serum Hormone Levels in Healthy Adult Men: A Double-Blind, Randomized, Placebo-Controlled Pilot Study
PMID: 26421049 2015 RCT (double-blind) n = 20
Finding: Sperm concentration and motility showed rising trends vs placebo; no significant hormone changes. Study underpowered (n=20), no p-values reported.
🟠 Limited quality Effect size: null
View on PubMed
Lepidium meyenii (Maca) improved semen parameters in adult men
PMID: 11753476 2001 Cohort n = 9
Finding: Increased seminal volume, sperm count per ejaculum, motile sperm count, and sperm motility observed; hormone levels unchanged. No control group; no p-values reported.
🟠 Limited quality Effect size: null
View on PubMed

🏛️Regulatory & authoritative positionsL4/L5 · FDA / EMA / NIH ODS / Cochrane / Mayo …

L4a US FDA
Cautious
FDA advised consumers not to purchase or use Peru Maca. FDA laboratory analysis confirmed that Peru Maca contains sildenafil, the active ingredient in the FDA-approved prescription drug Viagra, used to treat erectile dysfunction. source↗
L4b EU EFSA
Cautious
L4d TW TFDA / 衛福部
Cautious
「Maca猛戈膠囊」(紳○實業有限公司製造)含有西地那非(Sildenafil citrate,即威而鋼成分)及他達拉非(Tadalafil,即犀利士成分),副作用包括降低血壓、頭痛、嘔吐、頭暈及暫時性視力模糊,並可能和某些藥物產生交互作用,衛生署呼籲消費者不要購買及服用誇大療效之產品。 source↗
L5c Cleveland Clinic
Neutral
L5e Specialty Society (condition-mapped)
Not addressed
PMID 100% verifiedevery citation checked via NCBI Entrez
🔬5 PubMed studiesindependently re-checked by multiple sub-agents
engine_version: v1.0 claim_id: CLM-COND-male-infertility-INT-maca-001 繁體中文版 →