Calcium D-Glucarate for Liver Health
There are no human trials showing that calcium D-glucarate improves any measure of liver health, so its popular "liver detox" positioning rests on mechanism and animal data rather than proven clinical benefit. The evidence is graded Unverified, not effective.
Why this grade7-layer evidence engine
The grade is Unverified because not a single human trial has tested calcium D-glucarate against a real liver outcome such as ALT/AST, liver fat, NAFLD or fibrosis. The supporting literature is thin and old: 1990s rat studies showing the compound inhibits beta-glucuronidase by roughly 37-70% in serum and liver tissue (PMID 2346674) and a rat pharmacokinetic study establishing how it is absorbed and converted to the active metabolite (PMID 9101079). Narrative reviews (PMID 12197785, PMID 7744577) only restate this rationale and explicitly note that human outcome data are very limited.
The one recent paper invoking liver detoxification (PMID 36771439, 2023) is not an experiment at all but an industry-funded computer simulation by authors affiliated with Applied Food Sciences and CytoSolve. The engine flags this conflict of interest, and a modeled dose-response cannot substitute for clinical results. Mechanistic plausibility is real, but its translation into measurable human liver benefit has never been validated.
Authorities reinforce the caution. Examine.com has no entry, NIH/MSKCC notes the compound has not been shown to treat or prevent disease in humans, and Mayo Clinic warns that liver "detox" supplements are usually a bad idea and can even cause harm. Only Health Canada grants a limited structure-function claim that it "helps support glucuronidation," which is a marketing-tier statement, not proof of clinical efficacy; the FDA, EFSA and others grant no such claim. A drug-interaction flag also applies, since accelerating glucuronidation may lower levels of medications cleared by that pathway.
Scoring transparency
All scores computed by a 7-layer evidence engine — fully auditable▸View the full decision path (audit trail)
- compute_raw_score — 加權公式: L2×0.30 + L3×0.25 + L5×0.25 + L11×0.10 + L1×0.10 = 0.42
- tier_from_score — 依分數區間映射至 tier letter
- apply_hec_rules — 無高階證據可裁決
- tier_strict_requirement_check — | C→U 因 scope.conflation_risk=true 且 L11 獨評較低 (B7-2 tier cap)
- detect_disputes — 偵測到 1 個 hard + 1 個 soft dispute
- decide_status — 依 tier + dispute 結果決定 status