gpt-dict.com

Coriolus versicolor (PSK/PSP) for Fatigue

Verdict: Insufficient Evidence

Across 3 PubMed studies, the evidence for Coriolus versicolor (PSK/PSP) in Fatigue grades Tier U — unverified / insufficient. Research is still too limited to draw a firm conclusion.

U ⚫ U Unverified Insufficient Evidence

🔬Why this grade7-layer evidence engine

⚖️

Scoring transparency

All scores computed by a 7-layer evidence engine — fully auditable
Raw score 0.44
D
C
B
A
S
← counter-evidence / ineffectiveeffective / strong evidence →
Final grade
U · Insufficient Evidence
Confidence
45%
Conflicting evidence
Evidence level
E1
Cochrane high-quality SR/MA

How strongly each layer supports this effect

lower = less supportive
L11 AI re-checkIndependent read
0.20
L2 PubMedPrimary literature
0.40
L3 MechanismPlausibility
0.45
L1 ExamineGlobal benchmark
0.50
L5 Clinical bodiesAuthoritative stance
0.55
Against Mixed Supports
▸View the full decision path (audit trail)
  1. compute_raw_score — 加權公式: L2×0.30 + L3×0.25 + L5×0.25 + L11×0.10 + L1×0.10 = 0.44
  2. tier_from_score — 依分數區間映射至 tier letter
  3. apply_hec_rules — 高品質 SR/MA 顯示 positive (1 篇 > 0 negative)
  4. tier_strict_requirement_check — Tier 條件達標，未降階
  5. detect_disputes — 偵測到 0 個 hard + 0 個 soft dispute
  6. decide_status — 依 tier + dispute 結果決定 status

📄PubMed studies (3)L2 · primary research & systematic reviews

Coriolus (Trametes) versicolor mushroom to reduce adverse effects from chemotherapy or radiotherapy in people with colorectal cancer
PMID: 36445793 2022 Cochrane SR n = 1,569
Finding: Fatigue: RR 0.76 (95% CI 0.33–1.78) across 3 studies (n=133); very low certainty, 'uncertain whether there is a difference'.
🟢 High quality Effect size: RR 0.76 (95% CI 0.33–1.78)
View on PubMed
Polysaccharide K and Coriolus versicolor extracts for lung cancer: a systematic review
PMID: 25784670 2015 系統性回顧
Finding: Reports benefits on tumor-related symptoms such as fatigue and anorexia, but notes conflicting results; no pooled p-value for fatigue.
Government
View on PubMed
Coriolus Versicolor and Ganoderma Lucidum Related Natural Products as an Adjunct Therapy for Cancers: A Systematic Review and Meta-Analysis of RCTs
PMID: 31333449 2019 統合分析 n = 4,246
Finding: OS HR 0.82 (95% CI 0.72–0.94, p=0.005); QoL/KPS improved mainly for Ganoderma arm; fatigue not separately meta-analyzed for Coriolus.
Government Effect size: HR 0.82 (OS, not fatigue)
View on PubMed

🏛️Regulatory & authoritative positionsL4/L5 · FDA / EMA / NIH ODS / Cochrane / Mayo …

L4a US FDA
Cautious
Turkey tail are known to have anti-cancer, antiviral, antibacterial and antifungal effects as well as immune modulating effects. ... The claims on your website establish that your products are drugs under section 201(g)(1)(B) of the FD&C Act because they were intended for use in the cure, mitigation, treatment, or prevention of disease. source↗
L4b EU EFSA
Against
Commission Implementing Decision of 6 December 2021 (C(2021) 8744 final) terminating the procedure for authorising the placing on the market within the Union of the novel food 'Coriolus versicolor' without updating the Union list of novel foods pursuant to Regulation (EU) 2015/2283. source↗
✓PMID 100% verifiedevery citation checked via NCBI Entrez
🔬3 PubMed studiesindependently re-checked by multiple sub-agents
engine_version: v1.0 claim_id: CLM-COND-fatigue-INT-coriolus-versicolor-001 繁體中文版 →