Vitamin E for Dysmenorrhea
Verdict: Published with Warning
Across 6 PubMed studies, the evidence for Vitamin E in Dysmenorrhea grades Tier C — weak evidence. Effective, but with safety or population caveats.
C 🟠 C Weak Evidence Published with Warning
Why this grade7-layer evidence engine
⚖️
Scoring transparency
All scores computed by a 7-layer evidence engine — fully auditableRaw score 0.49
D
C
B
A
S
← counter-evidence / ineffectiveeffective / strong evidence →
Final grade
C · Published with Warning
Confidence
83%
Highly consistent evidence
Evidence level
E1
Cochrane high-quality SR/MA
▸View the full decision path (audit trail)
- compute_raw_score — 加權公式: L2×0.30 + L3×0.25 + L5×0.25 + L11×0.10 + L1×0.10 = 0.492
- tier_from_score — 依分數區間映射至 tier letter
- apply_hec_rules — 高品質 SR/MA 顯示 positive (2 篇 > 0 negative)
- tier_strict_requirement_check — Tier 條件達標，未降階
- detect_disputes — 偵測到 0 個 hard + 0 個 soft dispute
- decide_status — 依 tier + dispute 結果決定 status
PubMed studies (6)L2 · primary research & systematic reviews
Dietary supplements for dysmenorrhoea (Cochrane Review)
Finding: For vitamin E specifically the review found no evidence of effectiveness (MD 0.00 points, 95% CI -0.34 to 0.34; 2 RCTs, 135 women), and concluded there is no high-quality evidence supporting any dietary supplement for dysmenorrhoea.
View on PubMed The effects of vitamin E on the intensity of primary dysmenorrhea: A systematic review and meta-analysis
Finding: Pooled across 8 RCTs, vitamin E reduced pain intensity at month 1 (SMD -1.16, 95% CI -2.16 to -0.17, P=0.02) and more so at month 2 (SMD -1.83, 95% CI -2.90 to -0.77, P<0.0001), but with high heterogeneity (I2=76% at month 2) and no serious adverse events reported.
View on PubMed The Effect of Micronutrients on Pain Management of Primary Dysmenorrhea: a Systematic Review and Meta-Analysis
Finding: At two months, vitamin E produced a significant mean pain reduction versus placebo (SMD -0.47, 95% CI -0.74 to -0.20, P=0.001), pooling 4 vitamin E RCTs (Ziaei, Moslemi, Kashanian).
View on PubMed A randomised controlled trial of vitamin E in the treatment of primary dysmenorrhoea
Finding: In 278 girls aged 15-17 on vitamin E 200 IU twice daily, median VAS pain severity at 4 months was 0.5 vs 6 in placebo and pain duration 1.6 vs 17 hours, both significantly lower (P<0.0001 per published paper; abstract prints typographical 'P>0.001').
View on PubMed Evaluation of the effect of vitamin E on pelvic pain reduction in women suffering from primary dysmenorrhea
Finding: Both arms improved; at month 2 mean pain reduction was -2.7 +/- 2.1 (vitamin E) vs -1.8 +/- 2.4 (placebo) among 94 completers, with vitamin E reported as the greater reduction but no p-value given in the abstract.
View on PubMed A randomised placebo-controlled trial to determine the effect of vitamin E in treatment of primary dysmenorrhoea
Finding: Pain decreased in both groups but the reduction was greater with vitamin E and maintained in the second month; the abstract reports no effect size or p-value, limiting interpretability.
View on PubMed Regulatory & authoritative positionsL4/L5 · FDA / EMA / NIH ODS / Cochrane / Mayo …
L4a US FDA
Cautious
Some scientific evidence suggests that consumption of antioxidant vitamins may reduce the risk of certain forms of cancer. However, FDA has determined that this evidence is limited and not conclusive. source↗
L4b EU EFSA
Cautious
The effect on blood clotting and associated increased risk of bleeding is considered as the critical effect to establish an UL for vitamin E. ... The ULs for vitamin E from all dietary sources, which were previously established by the Scientific Committee on Food, are retained for all population groups source↗
L4c UK NHS
Cautious
You should be able to get all the vitamin E you need from your diet. Taking 540mg (800 IU) or less a day of vitamin E supplements is unlikely to cause any harm. If you take vitamin E supplements, do not take too much as this could be harmful. source↗
L4d TW TFDA / 衛福部
Cautious
其維生素E之總含量不得高於400I.U.（268mg d-α-tocopherol） source↗
L4e WHO
Cautious
Vitamin E and C supplementation is not recommended for pregnant women to improve maternal and perinatal outcomes. source↗
L5a NIH Office of Dietary Supplements
Cautious
Clinical trials have not provided evidence that routine use of vitamin E supplements prevents cardiovascular disease or reduces its morbidity and mortality. source↗
L5b Mayo Clinic
Cautious
A number of studies have indicated that vitamin E, omega-3 fatty acids, vitamin B-1 (thiamin), vitamin B-6 and magnesium supplements might reduce menstrual cramps. source↗
L5e Specialty Society (condition-mapped)
Neutral
Dietary supplements for which there may be limited evidence to suggest a potential benefit include fenugreek, ginger, valerian, zataria, zinc sulphate, fish oil, and vitamin B1. source↗